ACTH (he taiaki) - he aha te mea te reira? ACTH

hāngai ana te mahi o te tinana kei runga i te pāhekoheko o te katoa o ona anō wāhanga - kopa, i nga okana. Heoi, nga tauwehe matua o ratou mahi he matū koiora o te hanganga rerekē. Ēnei ngā hanganga ngā hormones. Ko tētahi o ēnei matū he adrenocorticotropic nui taiaki (ACTH ranei).

ACTH (he taiaki) - he aha te mea te reira

hua ana tēnei taonga e te repe - matua repe endocrine kawenga mo te mahia o tata mahi katoa. Hoki te hanga o te ACTH whakatau pūtau eosinophilic o te rapae o mārōrō,.

Iritihia i te ingoa Latin o te taiaki mooni oro rite "e pā ana ki te repe adrenal." Tuku i te rere o te toto ki a ratou, te taonga tīmata te mahi o enei repe, e whakatairanga te whanaketanga o āpiha adrenal motuhake. hāngai ana te tikanga o te mahi o hormones enei repe i te faaitoitoraa o tata nga huarahi paruru katoa e kaha faaite ake i raro i te ahotea.

I tahaki, ACTH ko te muingota o te pūmua. Ko te tino matatini tona hanganga: he reira maha wāhanga, ia o nei mahi he mahi motuhake (hononga ki receptors motuhake, stabilizes te mahi o whekau, he kawenga hoki te pānga immunogenic).

Taonga pupuri te ungeri circadian, arā i te wa ona kukū nui atu i roto i te tahi atu mau taime.

biosynthesis

Ka rite ki te ACTH synthesized (he taiki)? He aha te mea te reira, he uaua ki te matau, mai i te rāpoi ngota, me te whakakotahi i ngā huānga o pūmua (waikawa amino) me te rōpū hydroxyl (-OH), me mau huru o amines biogenic (-NH2). Mai te nuinga o te rāpoi ngota ko te mekameka o ngā toenga waikawa amino e conventionally te whakaaro reira ki te waiho i te peptide pūmua ranei.

synthesized te rawa te i te pūmua kawainga pera-ka karanga. Ka rite ki te pūtake mo te kōtuitui o pro-opiomelanocortin mahi taiki rāpoi ngota.

whakaputaina taiki Adrenocorticotropic, rite kua whakahuatia, e i roto i te hononga ki te manawataki circadian, arā te wa o te ra. , He ti'aturi i runga i taiaki hoki te kōtuitui - corticotropin (tīmata taiaki hypothalamic kawenga mō te triggering te rapae o). mātātoa Corticotropin whakaputaina i 6 am ki 9 am, me te maha iti rawa o ona kitea i roto i te toto i waenganui i 19 me 23 haora. Runga anō i tenei, a ka variruetsya nui o ACTH i te toto.

Ko te tūranga o te ira

Ka rite ki whakahuatia, taiaki adrenocorticotropic he kawenga mo te mahi o te repe adrenal. Whiwhi ki o ratou bloodstream, te taiaki whakaihiihi ana te hanga o glucocorticoids - cortisol, cortisone, me te adrenokortikosterona. E mātātoa ēnei taiaki whakamahia e te tinana ki te whakaongaonga te hunga atu pūtau me repe ranei. hāngai taiaki mahi tikanga i runga i to ratou here ki receptors adrenergic motuhake kei roto i te kopa maha, me oko toto. Ka rite ki kōrero i runga ake, enei hormones e "ahotea", i.e. ake i te mahi o te kaiao i te aroaro o te mōrearea rite ki te hua o tetahi tukumate.

Ēnei hormones i te pānga anti-inflammatory kaha, hanga kua ratou pārōnaki waihanga whakamahia i roto i te rongoā.

I tua atu, i waenganui i te ACTH me hormones adrenal he tetahi hononga: he taonga whakanuia ana te kukū o hormones adrenal me arata'i ratou i te taikaha ki te meka e mutu te whakaputa ACTH (taiki). He aha te mea mo te āhuatanga, me te aha kei te tupu tenei - e kore e mohiotia ano, engari ka karanga te lēsoni iho te "urupare".

Ko te hiranga haumanu o

ACTH whakaongaonga te mahi adrenal. Te kore tenei taiaki, e kia hohekore enei repe, e pai arahi ki tini o nga mate.

Heoi, i te reira te tahi mau taime te tupu, me te kia e te nui o te ACTH i toto rerekē, me he tika tona whakamāramatanga. Taiki ACTH, te tere o nei i roto i te toto, ka kia rite ki i 9 ki te 46 wae (wh / ml) tohu te mahi mahi noa, me te tika o te rapae o. ia haafaufaahia te nui o te taiaki ai ranei hekenga (nuinga - ki te kore tino o te reira i roto i te toto).

Hei whakatau i te taumata o te peptide whakamahia whakamātautau ACTH.

Kei te nuinga o te reira i kawea i roto i roto i te wā o te aroaro whakapae o mate. e kore te iwi hauora whakahaere i tēnei ako whakaaturia.

Whakawa i te taumata o te ira tangata i roto i te kukū toto, faaoti e, i runga i te mea kua oti maturuturu iho ko te tukanga pathological - i te taumata o te tuaka hypothalamic-rapae o tika ki tetahi hononga i waenganui i te taumata o te repe adrenal me te repe.

Whakatau i o ngā taumata toto taiaki

Ka rite ki kua whakahuatia, ki te whakatau i te kukū o te taiaki tika ki ACTH - test. Tenei tukanga taea ki a koe te whakatau mehemea tenei taiaki i roto i te toto.

I runga i te eve o te ako e tūtohu ana e kore e ki te mahi i mahi kaha, me te ki te haapae i te ava, me matū psychotropic. Ehara i tūtohutia hoki kai whakapeka, me te paowa. 3 haora i mua i riria te ako te ki paowa.

Kei te nuinga o te wā mahi toto ki runga i te puku kau i roto i te ata (anake, ki te reira e kore ture tafe'anga motuhake). I roto i ētahi wā (hoki whakapae mate o Cushing), ako te taiki i roto i te ahiahi.

Hoki te rangahau i te toto venous o te manawanui. Ko roto i te mea i whakaritea e te ira adrenocorticotropic.

ACTH (tona taumata) i muri i e whakaritea nga hua ki ngā uara tohutoro (kei taiaki noa i 9 ki te 46 wh / ml). Kei te nuinga o te wā ka kite a tetahi ine mahora rite rerekē.

Ngā take mō te whakanui ake i ngā taumata o te ACTH

E mate nui haere ACTH? Ēnei tukanga pathological ngā:

• mate o Addison (mate parahi, iti hoki adrenal tuatahi). e whakatika taumata ACTH tika ki te meka e kore hua hormones repe adrenal.
• hyperplasia congenital.
• mate o Cushing (nui haere moni o te ira e tika ana ki nohanga pathological o CRH).
• Syndrome o hanga ACTH mōwaho (mate e pā ana ki te whanaketanga o te kiko rapae o te kawenga mō te hanga o ACTH i wāhi mohiotia).
• syndrome o Nelson.
• syndrome Paraneoplastic (puku).
• Here e pā ana ki tafa whētuki ranei.
• Virilism repe adrenal.
• Whakahaere o taero tika (hormones tika rapae o) ranei autaki (na roto i te pa ana te hypothalamus me te pehi i nga repe adrenal) whakahaere i te repe.
• ahotea Pākaha ranei āhuatanga tino.

taumata taiki iti

I raro i te mea tuku iho tikanga ACTH?

• Tuarua iti hoki adrenal. ko ACTH heke e tika ana ki te meka e e hormones adrenal whakawhanakehia i roto i te moni rawa nui, heoi, e kore i taea e te whakaatu tona mahi.
• puku adrenal (syndrome o Cushing). faarahi tenei hanganga te maha o te kiko taiki-whakaputa, rite ki te hua arata'i ki nui haere ngā taumata o adrenal kōtuitanga hormones ACTH me inhibition.
• Mā te kriptogeptadina. E hāngai ana tēnei raau te i pehi te pokapū matekai kei roto i te hypothalamus. Ka rite ki te hua, e taea te tāmia tenei me te kōtuitanga liberinov.
• neoplasms Kortizolprodutsiruyuschie. Ahua rerekē i te puku ki te syndrome o Cushing, ko te pānga ko te taua.
• Ko te whakamahi o te raau taero glucocorticoid i roto i pota tiketike. ara te hiraka te whakaiti i te hanga tūturu o hormones adrenal, engari e tika ana ki nohanga nui o tāuru mutu te whakaputa ACTH.

Maimoatanga o tūroro ki huringa i roto i ngā taumata taiaki

Pehea e taea te whakaora e te manawanui, ki te mea kua nui haere ia ira adrenocorticotropic?

ACTH (he taiaki) e taea te whakahaeretia e te therapy tarukino, te rongo me te whakamahi o ngā tikanga hāparapara.

therapy Medical ngā te whakamahi o cytostatics (ka whakamahia hei hua, me te ki heke taumata taiki). Nuinga o ngā wā, kei te whakamahia ratou i roto i te whakau i te aroaro o te mate pukupuku. Ko te whakamahia tino whānui "Hloditan", "Mercaptopurine".

Kei te whakamahia radiation therapy mo te wāhi o te puku hanganga i roto i te rohe o te roro. Te whakamahi gamma-therapy ranei pānga iraoho.

whakaritea wawaotanga hāparapara te i roto i te take o te kore o te maimoatanga momo (taero me irradiation). repe adrenal te nuinga o nekehia, aru i te hahau kaha. E nekehia atu te pukupuku Brain hoki, Heoi, ko te tino matatini te wawaotanga, na kua kawea reira i roto i pinepine.

Fifi e pā ana ki ngā huringa i roto i ngā taumata taiaki

Reira i tupu pinepine e kia he taumata nui haere te heke haere ranei o ACTH arahi ki ngā pōauautanga.

raruraru adrenal - te huru tino noa e arata'i ki te meka i nui haere ACTH (he taiki). He aha te mea te reira?

āhuatanga raruraru adrenal e taumata tomuri nui o hormones adrenal e faaite tachycardia, nui haere te pēhanga. Ki tenei whakamārama, maha whakawhanake patua ngakau me nga whiu. I tua atu, kia te raruraru arahi ki te kēkeno o te tinana, i te mea tino mōrearea a taea arahi ki te mate.

E tukupu ana i te taumata o te ACTH te tikanga arata'i ki te whanaketanga o te iti hoki adrenal, pāngia auau o te pouri tiango ranei. I tua atu, wāhanga pakaru me te mahi fakasekisualé (rite i roto i te repe adrenal hua moni iti o te testosterone, me te estrogen).

Ïa i roto i te tikanga ki te ārai i te whanaketanga o enei disorders, e tūtohu ana i roto i te wā ki te whakahaere i te taumata o hormones.