"Clopidogrel": analogues, te whakamahi, ā-ringa, utu

I roto i te tahi mau āhuatanga, whakahau tākuta rongoā "Clopidogrel"? Ka tohutohu mō te whakamahi, analogs, puka tuku, hanganga, pānga taha me tohu mo te whakamahi o tenei rongoā e te aroaro i roto i te taipitopito i roto i tenei tuhinga. I tua atu, ka ako koe i te uara o te tarukino me te tūroro whakaaro e pā ana ki reira.

puka Tuku me te hanganga

Ka taea e koe te hoko i te tarukino "Clopidogrel" I roto i te aha puka? pūrongo Guide e tukua te raau i roto i te puka o papa, e kua pani ki te paninga kiriata. I roto i te kotahi namunamu kei 14 nga wahi, i roto i te pēke - 14 28 ranei, i roto i te paihere pepa - 1 ranei 2 paraharaha ki te rongoā. Ko te whakauru matua kaha he clopidogrel i roto i te puka hauwai ngāwhā. Ko te wāhanga ngaahi houalotú roto i roto i te waihanga tarukino ngā reihuka anhydrous, stearate konupora, māngaro pregelatinized, te hinu Katoro hydrogenated, polyethylene glycol 6000 me te microcrystalline cellulose. Film paninga, i pani papa arā, o Titanium hāorarua, hypromellose, konumohe kararehe (e hāngai ana i runga i te tae Ponceau 4 R), me te polyethylene glycol 400 me 6000 whakatinanahia medicament 'Clopidogrel' (ka e whakaaturia utu i raro) mā te mekameka o drugstores, engari anake i roto i te aroaro o whakahaunga.

āhuatanga pharmacological

I roto i te maimoatanga whakapōauau, heke whakawhāititanga mōtepe piri e te tahi atu agonists. Mahi rongoā "Clopidogrel" (tohutohu mō te whakamahi, e wātea ana i runga i maha tukutuku hauora utu, arotake, me rota o ētahi atu kōrero whai hua, me te aroaro i roto i tenei pepa) mo e rua haora, pūkete kakama mōrahi mō te 4-7 ra i raro i te huru o te whakauru 50-100 mg ia ra. pumau pānga Antiplatelet i waenganui i te 7 ki te 10 ra puta noa i te roanga o te ora mōtepe.

Pharmacokinetics

I muri i whakahaere-waha o te tarukino "Clopidogrel" (75 mg - horopeta paerewa) Kei te tere whenumi i te wahi gastrointestinal, me te kukū i roto i te nui haere paku te wahi wai o toto, engari i muri i te 2 haora, me te tae te taumata e taea te whakaritea (0.025 g / L).

Kei te ngā metabolized reira i te ate. Ko te metabolite nui he pärönaki hohekore o te waikawa (āhua 85% tīmata rauemi komuhumuhu i roto i te wē). Ko te kukū mōrahi toharite i muri i te whakamahi toutou "clopidogrel" Ko 3 mg / l, e taea te kite i te reira kotahi haora i muri i ingestion.

taonga Active me metabolite herea irreversibly ki pūmua wē. tonu ngata kōrero.

I muri i whakahaere waha o te 14C-tapanga "clopidogrel" tata hawhe o te horopeta puta i roto i urination, e pā ana ki 46% - te tütae ki runga 120 haora. T1 / 2 o te metabolite matua - 8 haora.

Waiwai metabolite maha nga wa atu tūroro i muri i te taenga 75 tau o tau, e kore tenei e huri mōtepe whakawhāititanga me te wā toto.

Ko te wē toto i roto i te nui kukū tākihi o te metabolite ko i te 5 ki te 15 ml / min, te mea ka te pakeke mate toharite o reira ko te 30-60. Ahakoa te meka e te pānga inhibitory i roto i te tūroro ki te adenosine diphosphate - iti piri mōtepe whakawhāititanga i, nui haere te reira wa toto, me te i roto i tūao hauora.

iteraa papû

E mōhio koe, mo e take whakaritea te tākuta he rongoā ki te tūroro rite "Clopidogrel"? Analogs, a ka whakaritea e ia he medicament mo te ārai o pōauautanga thrombotic o patunga rere pūroto, infarction myocardial me piringa mate occlusive matua. maimoatanga tukutahi ki te waikawa ahipirini me "clopidogrel" rite whakaaturia i te ārai o pōauautanga thrombotic, e riro te take o te syndrome coronary whakapeka.

contraindications

'Clopidogrel' (utu i roto i pharmacies Moscow rohe ko e pā ana ki 510 moni) ki te tono counter ki:

• hypersensitivity;
• toto whakapeka;
• syndrome haemorrhagic ;
• nui waimaerotanga ate;
• niniiraa māuiuitanga intracranial me predisposing ki te whanaketanga o te toto (pūkahukahu puku, exacerbation o whewhe keté, hyperfibrinolysis, kohi);
• hē reihuka (mō ngā puka inenga kei roto te waiu huka), ātete galactose tuku, malabsorption syndrome kūhuka-galactose.

"Clopidogrel": te whakamahi me te inenga

Ko te papa rite ki nga tohutohu, e taea te tangohia ahakoa o kai. Hoki te ārai o ngā thrombotic i roto i te tūroro ki te patunga rere pūroto infarction myocardial ranei, whakahau rata nga ra "Clopidogrel" 75 mg. I roto i te mate whakapeka, meinga nei e te whanaketanga o rahi necrosis rere pūroto o te uaua ngakau, kia tīmata maimoatanga i nga ra tuatahi. therapy ki te whakamahi o "Clopidogrel" - kaua e nui ake 35 ra. kia tango Tūroro ki patunga rere pūroto tenei rongoa mo ono nga marama. A, no te nga pōauautanga thrombotic puta i roto ACS waho ara i te wāhanga ST, tīmataria maimoatanga te ki te fariiraa i tuku i uta horopeta (300 mg), a atu e kore e tangohia neke atu i te kotahi papa ia ra. kitea te kakama mōrahi te i muri i te toru marama. e kore e nui te roanga o te therapy ki 'Clopidogrel' (analogs me arowhānui aroaro i raro) kotahi tau. Ki te whakamārama o te syndrome coronary whakapeka ki ST wāhanga poipoi maha whakaritea 75 mg o te tarukino i runga i te rā ki te whakamahi kotahi-wā tuatahi o te utanga o inenga i roto i ngā ki āpiha thrombolytic me te waikawa ahipirini. Kia puta tohu, e hiahia ana koe ki te haere ki te therapy pahekotanga. homai Tūroro i runga i 75 tau o te maimoatanga te kahore te utanga horopeta.

tuwhena rawa

I te fariiraa i te raau taero i roto i pota pouri koutou tūtohutia, kitea e te hua i roto i te wa, me pōauautanga muri toto. I roto i taua āhuatanga, ka hiahia koe maimoatanga tika. I roto i te take, ina e hiahia ana koe i te ako tere o te wā toto auroa, e hiahia ana koe he huhu o TM. Kahore he raau motuhake.

Taunekeneke ki ētahi atu taero

fariiraa tukutahi o "clopidogrel" ki hua warfarin i roto i te hua i roto i te auau toto, i te mea he aha te mea tino houhou tenei huinga. faarahi te reira i te tupono noa o te toto, me te i roto i te maimoatanga o te tarukino i roto i ngā ki taero nonsteroidal anti-inflammatory, ahipirini, glycoprotein inhibitors me heparin.

pānga taha

Treatment medicament 'Clopidogrel' (kaiwhakamahi, te utu, te tikanga o te whakahaere me te inenga e whakaahuatia i roto i te taipitopito i roto i tenei rauemi) e taea arahi ki hopearaa houhou:

• pūnaha toto coagulation: i roto i o te therapy maha whakatika toto tuatahi o nga marama, puta hematomas; i te iti rawa - toto'akí; take taratahi - toto intracranial.
• pūnaha hematopoietic: i roto i te wā onge - thrombotic te purapura thrombocytopenic, granulocytopenia, anemia, tae atu pancytopenia, me anemia aplastic.
• pūnaha Nervous: wā puta ānini, paresthesia, whanoke; onge - taninito; take taratahi - hinengaro whakama me moemoea.
• oko Toto me te ngakau, maha e hanga e kanokanototo; ētahi wā i nui toto, vasculitis, te pēhanga toto tuku iho.
• pūnaha romahā: epistaxis, bronchospasm, toto pūkahukahu, pneumonitis interstitial, hemoptysis.
• wahi kūnatu: korere, dyspepsia, mamae puku, te toto i te wahi kūnatu, gastritis me te whewhe pekitīlia, ruaki, flatulence, whakapairuaki, kōroke, toto retroperitoneal, colitis, pancreatitis, stomatitis, kore ate whakapeka, kakā, nui haere whākōkī ate.
• pūnaha musculoskeletal: arthralgia, myalgia, rumati.
• Kiri: bullous rashes (Stevens-Johnson syndrome me necrolysis epidermal paitini, erythema multiforme), katoatia, ponana erythematous, me planus pukoko.
• Pūnaha mimi: hematuria, hypercreatininemia, glomerulonephritis.
• mate pāwera: edema angioneurotic, mate serum, urticaria, pseudoallergy tauhohenga.

A, no te te uaua kitea therapy ki tenei kirika tarukino, e kore e mohio a rite ki te hua o te fariiraa i te medicament, a kia rite ki te tohumate o te matao noa.

Ara

Medicine "Clopidogrel" ki te tūpato tino ka tango tūponotanga nui o toto rite ki te hua o wawaotanga hāparapara, disorders hemostatic. Ki te te hiahiatia pokanga, ka ko tino houhou pānga antiplatelet i kia whiua te whakahaere o te tarukino mo te wiki i mua i te wa o te pokanga i whakaritea. rongoa tiaki ngā whakaritea hoki maumaui nui o ate mahi, e taea meinga hemorrhagic diathesis. Ki te hiahia tohu o toto nui ki te ako i te pūnaha hemostatic. I tua atu, ki te hiahia te aroturuki tonu te mahi o te mahi mahi o te ate. Tūpato "Clopidogrel" whakamahia te ki heparin, NSAIDs, warfarin. A, no te kitea whakahaere rangahau whakamātautau kahore pānga carcinogenic me genotoxic o te raau taero, i roto i te tua, e kore e whakaturia te pānga i runga i te kaha whakahaere waka.

"Clopidogrel": analogs me arowhānui

Taurite (analogs) taero - he rongoā he te mahi ano ranei he te taua hanganga. He aha ngā rongoā e taea te whakakapi rongoā "Clopidogrel"? Analogs faaineineraa o te taonga kaha te whai ake: "Kardutol", "Detromb", "Agregal", "Trombeks", "Klopilet" "Trocken", "Plavix", "Plagril", "Plogrel", "Targetek", "Egitromb" "Clopidogrel Teva,".

Kei ia raau āhuatanga rerekē, na tukua te whakamahi te i muri i anake kōrero ki tō tākuta.

Opinions e pā ana ki te rongoā

He aha te iwi e mea e pā ana ki taua faaineineraa rite "Clopidogrel"? Reviews o tūroro nei i te whai wāhi ki te whakawhiti e tino pai mate kino me wawaotanga hāparapara. pūrongo tūroro tiketike mahi pai o te medicament, e kore te otiia tikanga reira mo te fariiraa i roto i te tikanga ki te whaiaro rongoā-. Analogues o taero ki te āwhina tūroro whiriwhiri te kōwhiringa pai mo ratou i roto i te ōwehenga o te utu me te kounga, engari kia te whakaaro, me te whai huatanga o te mana kia tukua ki te tohunga mātanga.