"Kardosal": ako ā-, arotake, ngā whakaahuatanga, analogs

"Kardosal" (ingoa ao - "olmesartan medoxomil") ko te enemi o te angiotensin II receptor (momo AT1) - tuatahi RAAS taiaki vasoactive e pā ana ki te whanaketanga o te takawhita faufaa.

Puka tuku i te raau taero, ona wāhanga

E wātea ana i roto i te papa e kua hipoki e te takotoranga te tarukino. taonga Basic, hoki nei ngā he medicament o olmesartan medoxomil whakamahia i roto i te papa i te 10 ki te 40 mg ( "Kardosal 10", "20 Kardosal", "Kardosal 40").

I tua atu, ko te tarukino i honoa stearate konupora, microcrystalline cellulose, monohydrate reihuka. Ano, ka rite ki pŭpŭ tauturu koponentov giproloza whakamahia me iti giproloza whakakapi. Kei te hanga te anga i Titanium hāorarua ki talc tāpiri me te hypromellose.

pānga pharmacological

Kei te riro te reira e te tarukino "Kardosal" mahi i runga i te rauropi, whai wāhi ki te ārai i te pānga o te angiotensin II, takawaenga _AT1 receptor. I roto i Whakahekea takawhita medicament pēhanga matua, pumau tenei pānga mō te wa roa. E kore raraunga whakau i te takanga o te hypotension i muri i te whakamahi tuatahi o te horopeta tuatahi o te tarukino me te tachycardia tika ki therapy wā roa-( "Kardosal 20", "Kardosal 40"), te ahua o te withdrawal tahi e te hua koi i roto i te pēhanga toto.

Ko te whakamahi o te raau taero kotahi te hua ra i roto i te hekenga ngawari i roto i tohu pēhanga toto. whakawhanake te pānga e hiahiatia ana i runga i te 24 haora. Tikanga, tutuki te pānga hypotensive kei i runga i te tekau ma wha o te maimoatanga, te hua pai kitea i muri i maimoatanga o e pā ana ki e rua marama ra.

Pharmacokinetics

Ko te absorption o te raau taero, tona tohatoha

papa inu tere e te ahua o te metabolite kaha pharmacologically i te whēkau (e tika ana ki te mahi ka puta i whākōkī) me te toto tomokanga (i roto i absorption i te wahi gastrointestinal).

I roto i te haumanu hanganga o te wē toto e kore e kitea te taonga kaha tonu. bioavailability toharite Ko e pā ana ki 26%. faarahi o reira - te taumata mōrahi o te raau taero i kitea i roto i te toharite o rua haora i muri i tango i te reira, ki te whakanui ake inenga (80 mg horopeta kotahi).

"Kardosal 40", me te hua ki te inenga rerekē o te whakauru kaha, e taea te tangohia i waho arotahi i runga i te kohi kai. Kai tata kore pānga i runga i bioavailability.

Ko tata oti Hononga ki te pūmua wē, ka hāngai ki te 99.7%. Heoi, ko te whakamahi tukutahi "Kardosala" vysokosvyazyvayuschimisya ki ētahi atu taero te nui iti te reira.

pākia Drug me tona excretion i te tinana

ate Fele ahu tarukino (60%), te toenga (40%) - whatukuhu. he iti tohanga Intrahepatic o te taonga kaha. Mai whakaputaina excretion e te nuinga i te ate, maimoatanga ki āpiha "Kardosal me" te rāhuitia te reira, ki te he arai wahi biliary te manawanui. te whakamahi i muri toutou o rongoā wāhanga whakaaturia i runga i te toharite mō te 12 haora. kitea pānga pai ki runga ki te fariiraa i te inenga o te raau taero, e hāngai ana ki te maha pota o "Kardosala". Ko reira te pānga nui, me te i muri i nga ra tekau ma wha o te maimoatanga, e kore e ake nei whakaeminga puta. I roto i tenei ahua, kia rite ki kore te whakawātea tākihi pāngia e inenga tarukino rerekē, ko te reira i roto i te whānuitanga o i 0.5 ki te 0.7 L / h (āhua).

take haumanu Motuhake

Ko te hunga tūroro e i kitea i roto i te ofatiraa o te mahi tākihi (ngawari, āhua, nui), AUC nui haere e 62, 82, me te 179%, ka ko pūmau te huru.

A, no te faaite paku me tika raruraru ate,, AUC horopeta kotahi te whakanui ake tikanga āwhina ki te 6, me te 65%.

iteraa papû

tikanga te whakarite "Kardosal" ako i runga i te tono ka taea te rapunga o takawhita faufaa.

Tukinotia "Kardosalom" i roto i te hapū, ko te Kāore. Ki te ko te hapūtanga i roto i te tukanga maimoatanga, he mea e tika ana ki te hanga i te whakakāhoretanga o te tarukino.

Nā ki te kore o ngā raraunga tautoko te haumaru o te maimoatanga o te kai uma i te wa o te mutu maimoatanga ū.

Hei taea ki te hoko "Kardosal" ka timata ki te kia tukinotia ki reira, me tuhituhi te tākuta he whakahaunga.

contraindications

Contraindications ngā hypersensitivity ki aua matū e e ngā i roto i te waihanga, tamaiti (i raro i te 18 tau), hapū, uma-kai. I tua atu, e kore e whakaritea te pire i roto i te wā e whai ake nei:

• arai o te wahi biliary;
• te aroaro o te malabsorption syndrome, galactosemia;
• kore o te lactase;
• wā i muri i te transplant whatukuhu;
• täkihi i QC iti (iti iho i te 20 ml / min).

"Kardosal" - he tarukino faaterehia e te ki te tūpato tino ki tūroro ki tikanga:

• mate te AVC;
• hyperaldosteronism (tuatahi);
• disorders o te ate;
• täkihi, i roto i nei CD he nui atu i te 20 ml / min;
• stenosis, lesion tahi e mitral takirere te pūtahi o ranei;
• ma'i rere kore ngakau;
• mate iaia roro;
• kai tahi e iti konutai horomanga;
• hyponatremia, hyperkalemia (reira ko te mōrea o te iti hoki tākihi, hypotension maroketanga ranei);
• āhua, ka heke Ph puta ruaki, korere;
• stenosis, patu he iatuku tākihi anake, stenosis më, i roto i nei te iatuku tākihi pāngia;
• cardiomyopathy taunutia hypertrophic;
• tau ki runga i te 65 tau;
• te hiahia mō Diuretics.

Mā te "Kardosala"

E taunaki ana "Kardosal" ā-ako mā te whakamahi i 10 mg, e hāngai ana ki te horopeta tuatahi. A, no te kia pau iti māori o te pēhanga toto ia ra ki te 20 mg o tarukino. Ko Kāore horopeta i te taikaha o te 40 mg tarukino ia ra. rongoā Daily kia inu tetahi wa, i tetahi me te wa ano. Hoki tūroro ki ngā raruraru tākihi whakakitea ngawari ki te whakaōrite pakeke, ka ko te whakawātea i te whānui o i te 20 ki te 60 ml / min, te horopeta mōrahi "Kardosala" taea kore e neke atu i te 20 mg. I roto i te wā i reira i reira he he hiahia ki te whakapakari i te pānga hua e hua maimoatanga matatini (anake "Kardosala" tono "Hydrochlorothiazide").

pānga taha

I roto i te rongoā tarukino tukua "Kardosal" ā-ako taua pānga taha:

• urupare huakore i te pūnaha romahā me te kūnatu, te ahua o raruraru i roto i te pūnaha musculoskeletal, mimi, me whatukuhu, te huri i te tahi mau tawhā taiwhanga, te whanaketanga o te disorders pūāhua whānui (pērā pānga taha puta maha);
• whanaketanga o angina, te ahua o disorders e pa te pūnaha io (i ētahi wā puta);
• huringa i roto i te pūnaha Cardiovascular, te whanaketanga o te hyperkalemia (uaua kite).

pānga te taha e whakatika rawa uaua i muri i te fariiraa i medicament "Kardosal" tohutohu mō te whakamahi ngā:

• raruraru i roto i te pūnaha hematopoietic;
• mare;
• puka whakapeka o täkihi;
• raruraru kiri;
• syndrome asthenic;
• ānini, ahua whanoke;
• myalgia;
• āhua takiri;
• whakapairuaki tahi na roto i te ruaki, mamae puku;
• hua o te Urea, creatinine i te toto;
• huringa i roto i te ate - hua i roto i te mahi o ona whākōkī.

tuwhena rawa

Ko taea tuwhena rawa, faaite te reira i te whakaiti i tohua o tohu pēhanga toto. I roto i te take o te hua taua o te maimoatanga titau aroturuki auau o tūroro. Hei whakakore i te tohu e haere tahi tuwhena rawa te tikanga "Kardosal", tūtohu kaiwhakaako e mahi koe arotake maimoatanga symptomatic me therapy tautoko ki te haerenga, te pēhanga toto. I roto i te take o te tuwhena rawa takoto te manawanui i runga i tona hoki, me te ara i ana waewae. I tua atu, ka whakamahi i te horopeta nui o te tarukino tūtohutia te ki te mahi lavage pekitīlia, hoatu te tangata waro whakahohe. He he he hiahia mo te whakakapinga rōrahi, whakakorenga o maroketanga me te faaho'iraa mai o te toenga wai-tote. Mōhiohio e pā ana te taea o te excretion o matū olmesartan medoxomil i tātari i reira.

Ara

I roto i te tūroro e te aroaro o te therapy inarā tukinotia ki Diuretics ka piri ki te kai e katia atu te kohi o te tote, kia meinga hypotension rite ki te hua o te whakamahi horopeta tuatahi o te tarukino. Ka taea te kitea te taua hua i roto i te tūroro e kua puta ruaki korere ranei. Ko te take mō tenei tauhohenga o te tinana - whakaiti o BCC. kia araia hui kino o tenei natura. kia whakaaro te mōrea o tona takanga i mua i tīmata therapy.

Ki te mea kua pakaru te tangata nga whatukuhu, he mea nui ki te wā tirohia i serum rite creatinine, pāhare pāporo enei whika. Ko te whakamahi o inhibitors ACE i tūroro e kua pāngia hyperaldosteronism (tuatahi), he horihori, na e kore ratou e whakahau te tikanga "Kardosal" (whakaatu whakawākanga kahore whakautu ki inhibitors ACE).

Kia mahara ki e te heke kaha i roto i te pēhanga toto i roto i te tūroro ki te atherosclerosis, e pā te oko roro, ranei ki te mate te AVC taea meinga te whanaketanga o ngā āhuatanga kino pērā i te patunga rere pūroto, me te infarction myocardial.

Ki te ki te mahi i te tiaki o te mīhini tū matatini ranei pei i te waka i te tangata, he mea nui ki te mohio e tango "Kardosala" Ka taea e meinga he ino o te hauora (rohirohi, ngoikore, whanoke), ahakoa tupu uaua tenei.

Nā ki te ihirangi reihuka i roto i te raau tango riria reira ki te tūroro ki tuku pūāhua galactose ātete. Ko te taua pā ki tūroro ki malabsorption syndrome galactose me kūhuka, lactase hē i roto i te tinana.

Ngā pāhekoheko ki ētahi atu taero

Me tuhituhi te tākuta he whakahaunga me te kitea i roto i te mea e tukinotia te manawanui e te tahi atu tikanga ki te ārai i tauhohe e hiahiatia. E kore e tūtohu ana ki te whakamahi i rua "Kardosalom" me nga momo e whai ake nei o taero:

• tikanga kei roto pāhare pāporo;
• whakakapi tote, e ngā hunga o te pāhare pāporo he reira;
• Pāhare pāporo-tohu Diuretics;
• rongoā e pā taumata pāhare pāporo i roto i te serum toto (te whakanui ake i tēnei ahua).

He tauira o taua tikanga ko te "Heparin". He mea e taea ki te whakaawe i te ihirangi o te pāhare pāporo i roto i te toto. I eita o maimoatanga whakarato "Kardosal" analogues ha faingamālie ki te hanga i tona whakakapinga.

kitea whakapakari o te pānga antihypertensive te ka ie te maimoatanga o te tahi atu raau taero antihypertensive ko NSAIDs, te whakatinanatanga o te maimoatanga whānui. Therapy ki te huarahi integrated whai wāhi te whakamahi o Cox-2 inhibitors, waikawa ahipirini (horopeta rā - neke atu i te 3 g). Ko te mahi o te angiotensin II te raveraa ra receptor taea e synergistically awe te filtration glomerular i tona whakaiti.

Ki te whakamahi tukutahi o taua medicaments rite angiotensin II te raveraa ra receptor, ko NSAIDs, i reira te mea he tūponotanga ka o whakapeka āhua täkihi o te manawanui. Hoki tenei take, kia whakamana auau te aroturuki o te mana tākihi i te wāhanga tuatahi o te maimoatanga. Taua maimoatanga kia tino inu fluids nui. Heoi, ko te whakaiti taea i roto i te pakeke o te mahi antihypertensive, ai kite ino te pinepine whai huatanga o te therapy.

Ki te whakamahia "Kardosal" kei roto i te waikawa wā maimoatanga, ara waihā konumohe , me te konupora, i reira te mea he whakaiti mōrearea i roto i te bioavailability o te taonga kaha (āhua).

korerotia te reira reversible taumata piki konukōhatu i roto i te serum toto, me te whakaatu i ngā āhuatanga paitini hua i te tiritiri o inhibitors ACE, angiotensin II te raveraa ra receptor me taero kei roto konukōhatu. I roto i te hononga ki taua huinga therapy karere "Kardosalom" me taero, tetahi o nei wae - lithium, e kore e tūtohu. Heoi, ki te vai he hiahia taua, kia mana o te toto auau.

Ko te utu o te raau taero, analogs, arotake

A, no te kore he faaue "Kardosal" papa rite te utu ki nga tūroro katoa, na he hiahia i roto i te taea o te maimoatanga ki te whakamahi o te tahi atu, tikanga whai hua atu ratou. "Kardosal" ki te ihirangi o te 10 mg o te whakauru kaha e taea te hokona mo te RUB 610, he tarukino ki e kua 20 mg o whakauru hohe te hanganga -. Neke atu i te 756 te horoitanga i. "Kardosal", ko tona utu he e pā ana ki 860 moni., Kei roto 40 mg o te wāhanga matua.

Ka rite ki te faaauraa, ina whai koe ki te whiriwhiri i tetahi atu tikanga o te whakatinanatanga o te therapy, hei utu o "Kardosala" ka taea e koe te tono i te rongoā "Olimestra" te whakaputa i te therapy ngā hāngai i runga i te whakamahi o "hydrochlorothiazide", "medoxomil olmesartan" ranei. Ka taea e koe te tango i te rawa o taua hoa rite "Lozarel Cozaar '' ranei '. I tua atu, mo te whakakapinga o te raau taero e tika ana "Nortivan" "Valsartan Zentiva".

Mōhio o taua formulations rite "Olmesar", "Plaunak". Ko te tikanga rerekē whakakapi i te moni taketake, he utu whaitake, me ngā tawhā bioavailability heke tetahi o nga rerekētanga, kia he iti whai hua ratou, ahakoa e taea akakoromaki i te reira ki te mahi.

E whakamahia tonu Analogs i raro i te te tirotiro tamau o te mātanga, he mea e tika ana ki te tirohia wā pēhanga toto. Ki te hiahia koe ki te tiki ake orotahi ki te whare "Kardosal" atu whakakapi tenei tarukino, whakatau te tākuta, tango ki pūkete te taime rerekē. Ki runga ki te rapunga o ngā kino i roto i te wā maimoatanga kia te orotahi ki te hanga i te mahi e tika ana i roto i te wā e hāngai ana ratou whakakorenga. I roto i te maimoatanga he mea e tika ana ki te tirohia i te pānga i runga i te tinana.

A, no te kore e taea te mahi i te taketake i waho te huri taputapu, kia hoatu hiahia ki taero hangaia e kamupene Pākehā whakamatauria. A, no te whakamahere ki te whakakapi "Kardosal" papa analogues tika i koe ki te whiriwhiri i te kounga teitei.

Comments mahue i runga i te Ngā Huinga tākuta-manawanui, whakaatu e te tarukino "Kardosal" i roto i te maimoatanga maha ai tauhohe kino, te noa tino o nei - te mamae pouaka me rohirohi tamau. Otiia ahakoa enei taime kino, he pai tonu te pānga hypotensive. titau ahua o ngā pānga kōaro tuku ki te mātanga mō te tohutohu, a kia huri i te talena maimoatanga.

I roto i te maimoatanga o te tūroro ki te matua takawhita kua whakakitea, he mea nui kia mana tūturu o te manawanui. Whakatinana o therapy, ko te kupu e whakarato te pānga e hiahiatia ana, ka whai i te āhua o te rauropi, a roto i te take o maumaui - ki te whakatika ia ratou i roto i te wā. integrated huarahi nui, engari e kore te mea nui maimoatanga tarukino, me te whiriwhiri ano hoki tatou i te kai motuhake. I roto i te tikanga maimoatanga hiahiatia - tautukunga ki aratau ngawari o te mahi, pae whakakahoretia o mau peu kino, whakawhāiti ngā mahi tinana, me te hanganga ture ki ētahi atu kaunihera e kua whakaarohia mō te tākuta te hua maimoatanga pai.