Ko te faaineineraa o Hepatitis C "sofosbuvir": arotake, tohutohu hoki te whakamahi

Drug "sofosbuvir" ki te ingoa hokohoko "Sovaldi" taea ki a koe te whakaora rawa kakā C, ko te hua pai whiwhi hohoro nui, whakapumautia nei e rangahau haumanu.

Drug "sofosbuvir" hamani ma'i āhua kakā C. Ngā therapy ki te whakamahi o tenei tarukino me ētahi atu taero e whakahaeretia ki tūroro pakeke. Medicine, me te hamani tūroro ki HIV tahi-mate.

Ko te wāhanga kaha o nga papa - sofosbuvir. E pani ratou, ka i roto i mg 400 o te taonga taketake. Ko te mōkihi kei 28 papa.

Āhuatanga e ngā marau tarukino "sofosbuvir"

Te raau depressing pānga i runga i te RNA-polymerase NS5B. Ka rite ki te hua, ona pānga i runga i te tinana he aukati tukanga tukuruatanga huaketo, e ko te kaihoko fakatupu o te kakā C.

Hea ki te hoko "sofosbuvir" i te utu utu

Ko te kōrero tino whai hua i runga i te āhua o ki te tiki humarie koutou "akoranga ki ora", whakairi ki runga ki ngā pae motuhake. Ko HCV.RU te rauemi nui me tino hapori nui - Russian-korero kakā forum "Kati", i mea i hanga i roto i te 2000. Ka rite ki te tikanga, papa matotoru hoki nui, kei te āta tirohia ngā mōhiohio katoa i roto i te mua, me te kua he aromatawai tūmatanui.

Ki te kore e tangohia e koutou ki pūkete te huinga, tetahi o nga tono tino ngā, i kitea e matou i runga i te ipurangi, ka karanga HCV24 URU HŌTAKA. Mō ētahi atu pārongo e pā ana ki ngā ratonga HCV24 ko i runga i te paetukutuku e pā ana o te hōtaka.

Tuhinga hoki te whakamahi o te raau taero

"Sofosbuvir" rongoā whakaritea ki tūroro ki kakā C, te mate ina whakawhitia ki te puka ma'i. Hei kia whai hua, maimoatanga e hāngai ana huarahi ngā. Pea te whakamahi o te raau taero i roto i te wā i reira pāngia te manawanui ki HIV i roto i tua atu ki Hepatitis.

Contraindications ki te fariiraa i "sofosbuvir" tarukino

e kore e rongoa whakamahi i roto i te take o te hypersensitivity ki ngā matū katoa e kitea i roto i tona hanganga. Ahakoa te meka e te raau e kore pānga i runga i te hua, kei te uaua whakaritea reira ki nga wahine o tau uri. E kore te te whakamahi o te raau taero i roto i te hapū, me te ū tūtohu, rite taea te whara i te reira i te tamaiti.

A, no te puta hapūtanga, kia whai i te pā tōraro i runga i tona akoranga te huinga o "sofosbuvir" ki taua tikanga rite "Arepa interferon" me "ribavirin". Hoki tenei take, i roto i te wā maimoatanga he houhou whanautanga tamariki. Kua whakaaturia ngā i roto i nei kua te tarukino "sofosbuvir" Kua whakamatauria i runga i kararehe, e tenei taputapu kua he pānga paku kino i runga i te uri. I mua i te tango kia āta pānui i koe te tohutohu ki te tarukino me te kōrero i te tohunga.

Inenga "sofosbuvir" tarukino

Treatment "sofosbuvir" Hepatitis C puka ma'i ai anake e kawea ki waho te hunga ngaio e whai wheako e hāngai ana. e kore te Monotherapy kawea i roto i, kua ngā tonu te tarukino ki ētahi atu āpiha. maha tūtohu ngā pakeke i te rōpū rā, o 400 mg (1 papa) moni. inu Tablet i roto i kai.

tikanga therapy "sofosbuvir" Hepatitis C taea muri ake ki te ono marama. Tino maha whakatika te hiahia taua ka reira e te tahi mau āhuatanga kino. tīpakohia te horopeta e hāngai ana i runga i te taimaha o te manawanui.

therapy huinga mō te kakā C:

• Tohuira 3-6 - ki te tarukino matua te tapiritia "Arepa Interferon" me "Ribavirin" (e te maimoatanga neke atu i te toru marama);
• tohuira 1, 4-6 - ato'a mahi "Arepa interferon" me "ribavirin" mo e toru nga marama ranei anake "ribavirin" mō te ono marama (whakatinana tuarua ahua anake ka ki te ngoikore te whakamahi i te tikanga tuatahi);
• 2 tohuira - ngā te tarukino te ki "Ribavirin", te tikanga puta whakaora i roto i nga marama e toru o te whakamahi rongoā.

Ki te tika, ate tangata transplantation, kakā C e he mate, i mua ki tona fariiraa o te "sofosbuvir" whakaritea tahi me "Ribavirin". I roto i te tikanga therapy "sofosbuvir" maimoatanga talena o tūroro ki te akoranga tahi o HIV me kakā taea te whakamahi ko te taua.

A, no te puta pānga taha tika ki te whakahaere ngā o te tarukino me "Arepa Interferon" tahi e maumaui nui o "Interferon" kore ki te whakaputa i whakaiti o te inenga whakapumautia mua ranei. Ki te te whanaketanga o nui pānga taha ko ki kupu, "Ribavirin", te horopeta me te whakaiti ranei te hanga i te whakakāhoretanga o te tarukino. E hanga e te rata haere whakatau peheé. I muri mai, ka hoki te manawanui ki noa, ka taea e koe te tamata ki te haere tonu te tango rongoa.

Mā te "sofosbuvir" tarukino

A, no te penei kaihoko "sofosbuvir" kawea tono o ngā rongoā i roto i tahi ki te horomanga kai. pire kawa, e kore e taea kuru reira me break, whai koe ki te horomia katoa.

Ki te, i roto i te rua nga haora i muri i tango puta te ruaki pire, e tūtohu ana ki te inu i tetahi atu. I roto i te wā i reira puta ruaki i muri atu i te rua haora, e kore te mea e tika ana ki te mahi i tenei mahi.

A, no te e mokowhiti ana inenga, ka haere kore ake atu i te 18 haora, he mea e tika ana ki te tango i te horopeta ngaro ki te kua i reira wa ake, e hiahia ana koe ki te inu i te horopeta i te wa mua.

Fakangata e o therapy

Ki te i roto i te akoranga o te maimoatanga ngā hei kua tika i roto i te whakakorenga o tetahi o nga taero, ka whakakahore i te rongoā "sofosbuvir". Manual tohu e raraunga i runga i te maimoatanga o ngā tamariki me ngā taiohi, te whakau i te whai huatanga o tenei tikanga, kahore. A, no te tukinotia tūroro kakā e mamae i te waimaerotanga tākihi (puka ngawari āhua ranei), i reira he kahore he take mo te kōwhiringa takitahi o pota. I roto i te tūroro mate kino whakaritea he horopeta motuhake o te moni e hiahiatia ana ratou tinana.

pānga taha "sofosbuvir" tarukino

A, no te penei "sofosbuvir", "interferon" me "Ribavirin" puta nga pānga taha ano rite i roto i te wā o te maimoatanga anake "interferon" me "Ribavirin". I roto i tenei take, e kore e ratou ahua rahi roa'tu,.

I roto i te raau maimoatanga ngā tohu "sofosbuvir" whakautu e tona huinga ki "Ribavirin" maha arata'i ki te whanaketanga o enei āhua:

• kārangirangi, rohirohi;
• ānini;
• nui haere te taumata bilirubin heke i roto i te pūtoto ranei;
• whakapairuaki;
• raruraru moe.

A, no te fariiraa i te tarukino taketake ngā te ki te whakamahi o "ribavirin" me "Interferon", maha taea te kite:

• myalgia, mamae i roto i te hononga;
• kore o te moe;
• mare, hāhā o te manawa;
• taumata teitei o te bilirubin;
• neutropenia, anemia, kore o tatau mōtepe, lymphocyte;
• kirika, Chills;
• kārangirangi;
• rohirohi tamau;
• kiri oranga, ponana;
• tohu kino o te wahi gastrointestinal;
• ānini, whanoke;
• hiahia rawakore.

A, no te whakaatu te tua, te "Ribavirin" engari "sofosbuvir" aratohu faaineineraa iti tūponotanga o te whakawhanake enei pānga taha:

• anemia;
• kōtītiti i roto i te wahi kūnatu;
• korekore;
• ngenge me te kirika;
• haehae;
• uaua te tutonu i;
• myalgia;
• mamae i roto i te hoki me hononga;
• nasopharyngitis;
• te vaivai o te pakiaka makawe;
• minamina, maroke nui;
• mare;
• ahua o te dyspnea raro kawenga.

A, no te ngā therapy, "Ribavirin" me "interferon", kia kia kitea nga tauhohe kino e whai ake nei i roto i ētahi wā:

• kite raruraru me te kukū;
• ngaronga o te houku kiri;
• Reflux;
• ngenge me te hūhi i roto i te pouaka, hoki;
• pakiaka makawe ngoikore;
• korekore;
• migraine;
• haehae;
• tahurihuri kau, me te faaiteraa o te wehi;
• kōroke;
• pūmahara rawakore;
• maroke membrane ngohi te te kōhao-waha;
• mate taimaha;
• hāhā o te manawa rite whakautu a te tinana ki te ahotea.

Kei te tino maha kitea tauhohe kino i roto i te wā o te maimoatanga "ngā arotake sofosbuvir ':

• nui haere kārangirangi;
• rohirohi tamau;
• whakaiti o te kukū o pūtoto i te toto;
• whakapairuaki;
• ānini;
• kore o te moe;
• taumata teitei o te bilirubin.

He Common pānga kino e whai ake:

• kōtītiti i roto i te wahi kūnatu;
• cramps uaua me te mamae i roto i a ratou;
• anemia;
• ngaro makawe;
• takahi tukanga romahā;
• korekore;
• aro pahara;
• mare;
• hāhā o te manawa, i te whakautu o te tinana ki te ahotea tinana;
• kirika;
• Rhinitis;
• kore o te kaha;
• huringa i roto i te huru kiri;
• Ua ite te mamae i roto i te hoki me hononga.

Ko te wā katoa o te fariiraa "sofosbuvir" faaineineraa me tika te tango te wahi i raro i te mātakitaki o te rata. I roto i kore take e kore e taea te whakarite takitahi te faaineineraa i homai.

taunekeneke tarukino

therapy Matatini whakamahi "sofosbuvir" tikanga whakawākanga tukua hoki te whakamahi taea i roto i te taikaha o te mōreatanga ngā. e kore e ngā tohunga tohutohu maimoatanga ki tenei tarukino i te wa ano, me te "Boceprevir telaprevir 'ranei'." Ko te taua pā ki te huinga o te tarukino me te rongoa e kua whakaaro kaha mahi glycoprotein whāpoapoa. Hoki raau taero ki ngā āhuatanga puritia "Phenytoin", "Karbamatsepin". O taea te tāutuhia enei rawa, me te marou o St John "Rifamycin". Ko te kaha ki te ngā etahi raau taero whakaturia rata.

Ara

Me whakaritea te akoranga o te maimoatanga ki te tohunga mātanga. He ko te mōrea o mate pāwera, kua whakakitea huangō, kanohi whero, ratou minamina me te puku, minamina, kiriuhi mucous, Rhinitis, ohorere. kia ngaro ētahi tūroro mahara, pea ru anaphylactic. Ki te mea i reira he tohu o te tauhohenga pāwera Me awhina rata, ki te tika - whakatikatikanga o te talena maimoatanga, ranei te whakakāhoretanga o te tarukino "sofosbuvir" i roto i te whānui.

e kore te "Sofosbuvir" analogues o te tarukino whakamahia mo te maimoatanga o te tūroro i raro i te tau o tau tekau ma waru, rite kore i te haumaru o tenei therapy i whakapumautia e te rangahau.

Ua itehia e, e te pā o ngā tauhohenga taha ko rawa i roto i tūroro pakeke i runga i 35 tau. Te tinana o te iwi taitamariki atu farii ki rongoā.

E tīpakohia faaineineraa e titauhia rata tango ki pūkete maha āhuatanga, tae atu mate tohuira. I roto i te maimoatanga o te kakā tukua tohuira tuatahi huinga o taero "Ledipasvir" me "sofosbuvir". I roto i te rua me te toru o nga tohuira he taea ki te whakamahi i "ribavirin" ngā tohuira i te tuatahi ranei te wha - "ribavirin" ki "Interferon".

Kua whakaaturia Studies e "sofosbuvir" tino tōtika hamani i te tohuira mate 1-4. I roto i te nuinga o te wā, oti te whakau i te pānga o te therapy ki tenei tarukino i roto i te aroaro o te tangata kakā e kore anake, engari ano hoki i te huaketo ārai tangata.

I roto i therapy, kia whakauru i te manawanui etahi here i roto i to ratou oraraa. E kore e taea e koe te mahi i te mahi e pā ana ki te hiahia ki te whakaatu i tiaki anō me ki whakautu hohoro ki te mea kei te tupu.

Hoki nga wahine hapu te tinana he ngā houhou "sofosbuvir" + "ribavirin" + "Interferon".

Ko te utu o te raau taero, arotake, analogs "sofosbuvir"

He mea utu i mohio e ina whakamahi koe i te "sofosbuvir" Ka kia tiketike rawa te utu o taua maimoatanga. He utu te tarukino, e taea te hokona ai mo e pā ana ki 16-25 mano. Euro. Ahakoa whakaaro te tarukino e whai hua i roto i te whawhai ki kakā rere te C, ko reira taea e kore e tauturu i te reira i roto i te wā katoa, no te mea te tinana i te katoa rerekē, me te tauhohe rerekē i runga i te tikanga rerekē. titau Treatment tiaki motuhake, kia kawea te kōwhiringa o te horopeta e hiahiatia ana i roto i te tākuta, tei te rota i runga i te wātea o te wheako mātanga i te maimoatanga o te kakā "sofosbuvir".

I te tahi taime e hiahia ana koe ki te "sofosbuvir" whakakapinga tarukino. Reviews tohu e, mo te maimoatanga o te kakā C, e kore nei e i whakakorea i roto i te wā whakapeka, taea te whakaritea nga tikanga tākuta, i te pānga rite. I roto i te analogues taea - "TSikloferon", "Ledipasvir", ". PegIntron" kia whakahau i te taote "Neovir" ranei "Algeron". Ka taea te whakamahi hoki i te maimoatanga "Ferrovir", "Daklatasvir". He whakakapi pērā i "Rebetol", "Ingaron". Ka taea e therapy e "reaferona EU", "Asunaprevirom" ranei "peginterferon". E mea pinepine, e tahuri tākuta ki "ribamidil", "Layfferona", "Altevira". tutuki te pānga rite te tika ki te fariiraa "Sovriada", "Pegasisa" "Meduna ribavirin." No whai hua iti "Roferon A". He atu raau taero o te mahi rite - "Intron A," "ALFARON". Pea te whai huatanga o te maimoatanga o te kakā B, e hāngai ana i runga i te whakamahi o "Realdiron" ranei "Moliksana".

"Sofosbuvir" (Ihipa - he whenua o te take te tikanga) - he tarukino utu, na kia kia koe rawa tupato ka hoko. He mea nui ki te whakarongo ki te mua o te iwi e kua hokona kē te tarukino. Ko te kupu e taea ki te mohio he aha te taha pānga puta tino auau, me ranei pakari pai raau ki te mahi. E kore noa hua Ihipa "sofosbuvir". hua hoki India tenei tarukino.

Kua haere te tarukino e rave rahi mau tamataraa haumanu. He pai rite ki te hua o te whakaaetanga o te tarukino e ono taua ngā tukanga i hanga i hāngai i runga i te hua. I roto i te whai wāhi rangahau o 1947 iwi, whiriwhiria tūroro ki kakā C. hoki te ako i te iwi nei kihai i tukinotia mua mo ratou mate, me te hunga tūroro nei tinana e kore e urupare ki te therapy whakamana mua.

kï miramira raau i roto i te maimoatanga o te mate ki ngā tohuira o te tuatahi ki te wha. Kua whiwhi hua pai rite ki te hua o te maimoatanga o te tūroro ki te rua kakā B me HIV. Tata 50-90% o te iwi whai wāhi i roto i te rangahau, me te mate ana i te mate ate kakā B te C, i kite whakautu virologic toitü. He maha tūroro ki te ahua ma'i o te kakā me HIV mate e tika ana ki te whakamahi o te raau taero whiwhi te hua taua. tuhia Virological whakautu ukauka i roto i 76-92% o te iwi ki te coinfection.

He tokomaha te iwi e mamae i te puka ma'i o kakā B te C, mahue urupare, mōhio e i muri i te wahi o te akoranga i whakaritea o te maimoatanga hoki ratou huru ki noa. I roto e toru nga marama o ngā kia noa tohu therapy o whākōkī ate, i muri e pā ana ki te ono marama o te mate, ko te taea ki te wareware ki te toto e kore e taea te kitea te huaketo. Mō ngā pānga taha whakauaua whakahuatia, he te tikanga iti ratou: te rohirohi, te ngenge. Ahakoa rongoa, kuo pau ke tau tupato e kore kua hoki mai te mate.

Ētahi iwi ki te mate o te rua o nga tarukino tohuira tauturu kotahi noa te marama, he pai nga hua o te tātari, e taea e kore e kitea te kaihoko fakatupu o kakā C i roto i te toto i muri i maimoatanga tarukino "sofosbuvir". taero Utu kaua nui, engari, e hiahia ana ki te whakaora me te wareware e pā ana ki tenei mate kino, te kakā C, he iwi i mōrea. pānga te taha e te tikanga ngawari ranei āhua ranei kore-te moti. Tonu, ko te tarukino pai mahia i raro i te mātakitaki o tou tākuta. No urupare kino, e te tikanga e te mea kua whakaritea tō tākuta te rongoā tika, me te utua whakarongo ki nga āhuatanga katoa o te tinana o te manawanui, tona hauora, ki te tutakina te aroaro o contraindications, kia kia pai te hua o te maimoatanga. He mea nui ki te matau e ko te tino nui te mātanga tohu i roto i te maimoatanga o te kakā e rere C ki te tiki hua pai me te ora tonu. mātakitaki o tākuta pūmau, tautukunga ki nga tūtohutanga katoa me te whakaū i te āhua noho hauora tino e arahi ki te pai te hauora. Ahakoa, ki te kahore te te mate whakaorangia tino angitu, ka whakapai ake i te tātaritanga o te tohu, e tika e whai i te pānga pai i runga i te hauora.