"Mirapex": tohutohu mō te whakamahi, whakaahuatanga, arotake

I roto i tenei tuhinga ka ako koe katoa e pā ana ki te faaineineraa "mirapex": me pehea ki te whakakapi i tenei tarukino, he aha te mea tona pānga, contraindications, pānga taha, tohutohu motuhake ki tona ringa. Ka taea e ēnei pire meinga whanonga rerekē, me te pānga i runga i te whakautu a te manawanui. Na reira, i mua i te tango i tenei rongoā kia āta ako "mirapex" tohutohu mō te whakamahi. korero hoki matou ki a koutou e pā ana ki te hototahitanga o enei pire ki ētahi atu taero.

Roa "mirapex": mōhiohio whānui e pā ana ki te tarukino me tohu mō te whakamahi

Ko te taonga kaha o te faaineineraa "mirapex" he pramipexole. Ngaahi Houalotú wāhanga Papa: povidone, mannitol, māngaro, aerosil, konupora stearate.

Ki te kawea tenei therapy tarukino te idiopathic (motuhake o ētahi atu pāpaka) syndrome o "waewae te pehi" me te mate o Parkinson me ētahi atu nekeneke parakore me disorders extrapyramidal.

Hua: pire "PD mirapex" 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0,375 mg. E Kikī ratou i roto i te opupu o te 10 nga wahi, a ka i roto i ngā pouaka pepa.

pire ma. E ratou he mata kuiti me te āhua papatahi i runga i ngā taha e rua, tetahi o nei he tūpono hohonu.

kia papa kia tangohia-waha, ahakoa o kai. whakaaetia kai tarukino te i tetahi wa. I roto i tenei take, kia horoia reira iho ki te wai. Kei te wehea Manakohia horopeta ia ki toru ngā wāhanga.

Ko te tikanga o te mahi (pharmacodynamics) "mirapex" Papa

taonga whai hua pramipexole e Kei roto i te faaineineraa "mirapex" āta me ki selectivity tiketike whakarei te whakautu o te Huingaiti o receptors dopamine D2. Ngā mihi ki a ia, utua hoki te kore o te mahi tinana i roto i te take o te mate o Parkinson. he tika ki te faaitoitoraa o receptors dopamine i roto i te striatum tenei. Ko te kupu pramipexole ārai te tupu o neurons e puta tika ki neurotoxicity ischemia ranei. inhibits reira ranei whakaiti te auau o te ariā, ka pākia, ka te tuku dopamine. Ngā mihi ki neurons pramipexole e tiakina i te pānga paitini o anti-Parkinson āpiha "Levodopa". e tika ana ki tona pānga hoki heke prolactin (horopeta-ti'aturi).

I roto i te take o te whakamahi roa o pire "mirapex" mo te maimoatanga o te mate o Parkinson (neke atu i te toru tau) me te syndrome o "waewae te pehi" (neke atu i te tau) kihai i whakakitea tōtika iti o pramipexole.

tukanga matüora e pā ana faaineineraa "mirapex 'i roto i te tinana o te manawanui (pharmacokinetics)

Hohe taonga "mirapex" te raau taero e whenumi rawa me tere i muri i whakahaere-waha. Tona kaha mo te whakawhenumi (bioavailability) ko tata tino - neke atu i te 90%. kitea te kukū mōrahi o te tarukino i roto i te wē i muri i 1-3 haora i muri i te kai. I kai heke pramipexole auau absorption. I roto i tenei take, e kore e puta ke te nui o te kai pänga.

pūmua C herea pramipexole paku (iti iho i te 20%). He he rōrahi tohatoha nui - 400 rita, e te tikanga e te kukū i roto i te toto he iti. Ki te whānuitanga iti kitea ki te tukanga tarukino pākia. Tata 90% o te horopeta "mirapex" pire excreted e nga whatukuhu, me 80% - tonu. kitea ana te pramipexole feces te i roto i te nui o iti iho i te 2% o te moni pau o te tarukino. E pure kikokiko me te tinana fluids i papa "mirapex" i te tere toharite o te 500 ml / min.

Mā te "mirapex" tarukino i roto i te hapū

Ka taea e te whakamahi ahau i roto i te hapū "mirapex" papa? Tohutohu mō te whakamahi o te raau taero hanga mārama reira e kore kua whakawakia te pānga o te raau taero i runga i te whanaketanga o te kukune i roto i te kopu, me te hohipera.

i ako te pānga taea o te pramipexole i runga i ngā pūnaha me nga mana kawenga mō te tukanga kikiritanga i roto i ngā i runga i te kararehe. e kore e faaite mai te reira i maumaui o te whanaketanga fetal te wā hapūtanga i roto i te räpeti me kiore.

kore kua excretion o pramipexole ki te waiu, uma i ako. Ka taea e anake tetahi amo e taea te taonga tautāwhi i te hohipera, mai production inhibits ira luteotrophic. Na reira, e kore e tangohia "mirapex" pire i roto i te whāngai ū.

I roto i te hapū, kia te tarukino kia tangohia anake, ki te te painga pea ki te whaea e tami te mōrea heke mai ki te kukune.

Contraindications ki te whakamahi o te mirapex papa ' "

Drug "mirapex" e kore e taea te tangohia i roto i te take o te hypersensitivity ki pramipexole, me te iwi kihai i nei i tae 18 tau o te tau.

Ki te tūpato motuhake tūtohu te ki te whakamahi i te papa i raro i te pēhanga toto iti me te hēnga o ōna whatukuhu.

pānga taha "mirapex" tarukino i runga i te pūnaha io

Te faaineineraa "mirapex" - papa e taea meinga te pūnaha io e whai ake tauhohe:

• whakama;
• hiahia nui mō te moe ranei ona kore;
• moemoea;
• mate wareware;
• asthenia;
• whanoke;
• syndrome extrapyramidal;
• hypoesthesia;
• faaati;
• myoclonus;
• dystonia;
• korekore;
• kuawa;
• hehema suicidal;
• hypokinesia;
• ataxia;
• manukanuka;
• neuroleptic syndrome mārere.

kite whakamutunga i roto i te puka o te tūāhuruiti, raruraru o mahara, me te whakaaro, uaua rigidity, lability autonomic, akathisia.

pānga te taha o pire "mirapex" i runga i te tahi atu ngā pūnaha o te tinana tangata

Ka taea e te pūnaha musculoskeletal urupare ki te whakamahi o ngā rongoā "mirapex" faaiteraa taua:

• uaua hypertonic, ratou haehae, aitua,;
• takanga o te rumati, gravis myasthenia bursitis ranei;
• mamae i roto i te pouaka, kaki tuaiwi ranei (i roto i te lumbosacral).

Ka taea e hoki ratou puta rerekētanga i roto i te pūnaha kūnatu. A, no te tenei puta:

• mate o te hiahia;
• kōroke;
• whakapairuaki;
• dyspepsia;
• flatulence;
• korere;
• ruaki;
• mangai maroke;
• tapahi mana'o i roto i te kopu.

Respiratory fariiraa "mirapex" o te raau taero e taea hua i roto i te whanaketanga o te pakohu kakā, pharyngitis, Rhinitis, syndrome rewharewha-rite. Ko reira ano hoki takanga taea o te hāhā o te manawa, nui haere mare me te huringa reo.

He aha te mea te pānga i runga i te Cardiovascular pūnaha "mirapex" papa? Tohutohu mō te whakamahi o te raau taero ngā pā ana ki taea tachycardia whanaketanga, arrhythmia, angina pectoris, hypotension orthostatic.

Ētahi atu ngā pānga taha

A, no te fariiraa i te tarukino "mirapex" kia puta i taua pōauautanga i roto i te pūnaha urogenital, rite te atu auau nekehanga whēkau, mate. Ko te kupu noa mahara mate o libido me mananga.

I tua atu, kia wheako koe rua kitenga, pokonga, pīkaru, pāpāngia o noho, mate pāwera, me te rongo waimaero, te pēhanga intraocular.

Ētahi atu tauhohe kino o te tinana:

• kakakīrehe retroperitoneal;
• effusion pleural;
• kookuhutanga pūkahukahu;
• mate taimaha;
• edema piringa.

Inenga me Whakahaere "mirapex" Papa

Hei whakamahi i te tarukino e hiahia ana koe i roto, rā 3 ngā wā. Initial horopeta "mirapex PD" papa - 0,375 mg ia ra. whakanui i āta te nui o tarukino tika (nga 7 ra) ki te whiwhi i te pānga haumanu hiahiatia. I roto i te wiki tuarua o te maimoatanga kia pau nga ra e 0.75 mg i roto i te toru o - ki te 1,5 mg mo te tuawha - i te 2.25 mg i roto i te hiahia ki te inu rongoa "mirapex" 3 mg ia, i runga i te ono o te rima - 3.75 mg, te whitu - 4.5 mg.

I roto i te täkihi ma'i, whakaritea te inenga e hāngai i runga i te taumata mahi o te creatinine whakawātea. kia whakaritea te nui tangohia o te tarukino te tākuta.

Ngā mutunga iho o te tuwhena rawa pire "mirapex"

Ki te whakamahi koe i i pakaru "mirapex" inenga tarukino, kia puta enei tohu hai moemoea, hyperkinesia, whakapairuaki, ruaki, heke te pēhanga toto me te mahimahi.

Hoki tenei āhuatanga, e kore e tāuta te raau. Kēhi o tarukino tuwhena rawa "mirapex" e kore te whakaritea. Manakohia therapy symptomatic, lavage pekitīlia me te mātakitaki hihiri. Ki te mea i reira he tohu o te tuwhena rawa o excitation o te pūnaha io pokapū, he mea e tika ana ki te tono i te taka, neuroleptics.

papa taunekeneke "mirapex" ki ētahi atu taero

Pramipexole e pā ana pūmua wē paku me biotransformation. Na reira, i tona pāhekoheko ki ētahi atu taero e pā enei tukanga e pea.

Drugs e tautāwhi i pehi te hanga o matū kaha samovyvodyaschiesya cationic ranei i roto i te tubules tākihi ranei, e taea te ariu ki te pire "mirapex". whakamārama Tohutohu mō te whakamahi i roto i tenei take i te whakaiti tere kitea te kopa purea me fluids koiora ranei i medicaments e rua ranei tetahi o ratou.

Ki te tukutahi ki mirapex "te pire 'whakamahia enei taero, kia utu koutou whakarongo ki te moemoea taea, dyskinesia, rōpū,. Ki te puta enei tohu, kia heke te inenga o te tarukino.

papa Hototahi "mirapex" ki taero "Amantadine" me "L-dopa"

Eaha te tupu, no te te fariiraa "Levodopa" raau taero ngā me "selegiline" pire "mirapex PD"? kī ako e kore e nga pharmacokinetics o te kaihoko kaha pā e kore te tuatahi e kore te tuarua. I te wa ano i runga i te Kawanatanga tonu me te excretion o te tarukino i roto i te ara tūturu "Levodopa" papa "mirapex" e kore e mohio.

kihai i Pramipexole ako te pāhekoheko o te tarukino "Amantadine". Ko he taea i roto i te therapy hototahi, mai to ratou tikanga rite o te excretion.

A, no te nui haere horopeta "mirapex" faaineineraa, ki te nui tono "Levodopa" tūtohutia whakaiti. Me te tiaki tonu i te maha o te tahi atu raau taero antiparkinsonian i te taumata kotahi.

Āhuatanga faaineineraa Hototahi "mirapex" ki ētahi atu taero

tūtohutia Nā ki te taea o pānga tāpiripiri ki te tūpato tino te ki te whakamahi i nga papa "mirapex" i roto i ngā ki sedatives, waipiro, me taero e te tauturu i ki ake i pramipexole kukū i roto i te toto (hei tauira, he tarukino "Cimetidine").

arata'iraa Motuhake i roto i te whakamahi o papa "mirapex"

Kei te whakaahua nei tatou i kore te tūtohu te tarukino ki te tango i roto i te taha ki te antipsychotics.

I roto i te maimoatanga o te dopamine agonist pānga taha mohiotia he whakama me moemoea. I roto i te wā o "mirapex" papa i roto i ngā ki te tarukino "Levodopa" taua abnormalities i nui atu auau i roto i te wāhanga i muri mai o te mate atu i roto i te monotherapy wawe.

Me whakamōhio te tākuta te manawanui o te takanga taea o moemoea ataata. pā ana tēnei pānga taha te kaha ki te pei waka, me te hanga whakatau kawenga.

I roto i te korenga atu koi o papa i roto i te take o te mate o Parkinson i kitea te ahua o te tohu e rite syndrome mārere neuroleptic.

whanonga Anomalous i roto i te whakamahi o "mirapex" tarukino

Tūroro me te hunga tiaki mo ratou, he mea e tika ana ki te mohio e maha ai te fariiraa o te raau taero dopaminergic, tae atu "mirapex" papa (arotake whakau tenei), whanonga rerekē o te manawanui. kia wheako koe hyperphagia (ma'unimā opue), hokohoko pathological (hiahia pokepoke ki te hanga i te rota o hoko), petipeti hairiiri me hypersexuality. I roto i te wā, pērā i te mea e tika ana ki te whakaiti i te inenga o te tarukino ranei āta mutu tango i te reira.

Tūpato i roto i te whakamahi o papa "mirapex"

Medicine "mirapex" kia pau ki te tūpato ki te tūroro ki te aroaro o mate nui o te pūnaha Cardiovascular. I roto i te whakahaere therapy ki taero dopaminergic reira ko te mōrea o te hypotension orthostatic. Na reira, he mana pēhanga toto, ina koa i te wāhanga tuatahi o te maimoatanga.

A, no te he e tika ana waimaerotanga ataata ki te tirohia wā reira tonu i muri i te whakarite o papa "mirapex" me wā tautuhi anō.

kia hoatu tūroro ki te meka e kia whai i te tarukino te pānga whakarokiroki. He kua take o moe ohorere, me te sleepiness nui i roto i te ra ki ngā mahi ra. Tae atu tenei kia puta i tetahi wa i roto i te whakahaere o te mīhini matatini peia waka ranei.

Ko te taea o te whakawhanake tonapuku

Ka rite ki te hua o ngā rangahau tātari tahumaero kua whakaaturia e tūroro ki te mate o Parkinson kei i mōrea o te mate tonapuku. He te take o tenei mate, ranei te tahi atu āhuatanga, pērā i te whakamahinga o "mirapex" kore i whakapumautia te tarukino.

Whakapakari i o te syndrome o "waewae te pehi"

Nahea te syndrome o "te pehi waewae" tarukino "mirapex"? whakaatu Mua e kia whakarei reira taero dopaminergic. whakakitea ana tēnei i roto i te puka o te tīmatanga mua o tohu i roto i te ahiahi syndrome me ētahi wā i roto i te ahiahi. I roto i tenei take, wherahia ana nga tohu ki ētahi atu wahi. Ko te tū mō te 26 wiki te ako te mana haumanu, i hangaia ki te ako i tēnei pānga, he rerekētanga nui i waenganui i pramipexole me placebo rōpū i roto i te whakarei ake i te āhuatanga o te syndrome Kua tāutuhia.

tikanga rokiroki me te ora papa

e pā ana "Mirapex" papa ki te faaineineraa o te rārangi B. Store kia waiho ratou i roto i te wahi pouri. I roto i tenei take e kore e nui ake te pāmahana rūma 30 ° C.

Papa-ora o te tarukino - 36 marama (3 tau) i te rā o te production.

Ko te whakamahi o "mirapex" papa i roto i te tamarikitanga, me ngā āhuatanga o te hoko

contraindicated te tarukino te mo te whakamahi i roto i ngā tamariki. whakaaetia whakaaetanga te ki nga tangata te whiwhi papa, e kua tae 18 tau o te tau. Medicine "mirapex" tukua i roto i te pharmacies i runga i te whakaaturanga o te whakahaunga.

analogues Drug "mirapex"

Koe e taea e kore, mo mea katoa take, ki te whiwhi i te papa, ko te "mirapex"? He aha e taea e whakakapi i te raau taero, kia korero koutou i te rongoā tākuta ranei. Na whakahere tatou nga analogues e whai ake nei.

1. "Motopram" pire. Tuhinga mō te whakamahi: mate a Parkinson. Ka taea te whakamana te reira anake ranei ngā ki rongoā rongoa 'levodopa'. Kei te whakamahia hoki te reira mo te kino āhua ranei ahua idiopathic o te syndrome o "waewae te pehi".
2. "Oprimeya" pire. Taumu'a: antiparkinsonian rongoa stimulant dopaminergic tuku i roto i te pūnaha io pokapū.
3. "Pramipexole" pire. Ko te kaihoko whakaora whakamahia i roto i te mate o Parkinson. Kei te whakapono te reira e te hono hāngai te huarahi o te mahi ki te kaha o te taonga pramipexole whakaongaonga receptors dopamine i roto i te striatum.

Papa "mirapex" - analogues taketake ranei? No whaiaro!

I roto i te hua whakarārangitia i runga ake, e he analogues o mirapex "papa '. E ratou te, ingoa taua ahurei ao kore-kamupene (ranei ATC-waehere), tūtohutia nei e te WHO (Health Organization World).

Ki te hiahia koe ki te mamae maimoatanga te whakamahi i papa ano e taea "mirapex" analogs kia he rerekē nui. Ko te aroaro whakakapi koe i te tikanga i whakaritea o te therapy, kia mohio ki te kōrero ki te mātanga. I raro i kore huru e kore te mahi whaiaro! Tenei e taea meinga hopearaa kino tina heke mō te hauora koutou.

Whakatūpato! Tenei tuhinga he kō he whakamārama o "mirapex" teuteu e ka māmā putanga o nga tohutohu e pā ana mō te whakamahi. aroaro mōhiohio Drug te mo te whakaaro o te arotake. I roto i kore take e kore e whakamahi i te reira rite te aratohu ki te whaiaro rongoā-.