Cephalosporins papa whakatupuranga 4. Paturopi-cephalosporins whakatupuranga 4

no cephalosporins ki taero beta-lactam. kanohi ratou tetahi o nga akomanga nui o raau taero antibacterial.

Overview

whakaaro āhua hou e cephalosporins whakatupuranga 4. e kore e wātea puka Oral i roto i tenei rōpū. Ko te toru e toe e faahoho'ahia e te tikanga o te whakamahi ā-waha, me te parenteral. Cephalosporins i hua nui, me te tāoke āhua iti. Nā ki tenei noho ratou i te tūranga ārahi i runga i te auautanga o te whakamahi i roto i te mahi haumanu o āpiha antibacterial katoa.

Tuhinga mō te Whakamahi mo ia cephalosporins whakatupuranga whakawhirinaki i runga i o ratou āhuatanga pharmacokinetic me mahi antibacterial. Rongoā i te faitatau hanganga ki te rongoā paturopi. whakatau te reira i te huarahi ōrite o ngā pānga antimicrobial, me te ripeka-mate pāwera i roto i te tahi mau tūroro.

whānui o te mahi

Cephalosporins i te pānga bactericidal. Kei te hono te reira ki te tūkino hanga nga taiepa pūtau o huakita. I roto i te tuatahi ki te toru whakatupuranga hehema ki tino whakawhānui i te whānuitanga o te mahi, me te whakarei ake i te mahi antimicrobial i runga i papapūata Gram-kino ki te pānga iti e tukupu ana i runga i microorganisms karamu-pai. Ki te whānui mō ngā āhuatanga pāpāho katoa ngā te ngaro o te nui pānga i runga i te enterococci me etahi atu papapūata.

He hiahia i roto i, he aha e kore tukua cephalosporins whakatupuranga 4 i roto i nga papa maha tūroro? Ko te take i enei taero i te hanganga rāpoi motuhake. kahore hoki e tukua te reira i te kai kaha ki te tomo i te hanganga o te pūtau mucosa intestinal. Na reira, e kore te mea e wātea ana te whakatupuranga cephalosporins 4 i roto i papa. te rongoā katoa i roto i tenei rōpū e hangaia mō te whakahaere parenteral. Wātea i roto i te 4 whakatupuranga o cephalosporins i roto i ampoules ki te whakarewa.

cephalosporins whakatupuranga 4

E whakaritea Drugs i roto i tenei rōpū anake e tohunga. Ko te kāwai āhua hou o ngā rongoā tenei. Cephalosporins 3, 4 whakatupuranga i rite whānui o ngā pānga. Ko te rerekētanga i roto i iti pānga taha i roto i te rōpū tuarua. Tikanga "Cefepime", hei tauira, he maha o ngā tawhā tata ki te taero tuatoru-whakatupuranga. Otiia e tika ana ki etahi peculiarities i roto i te hanganga matū, kua reira te kaha ki te tomo i roto i te taiepa i waho o microorganisms karamu-kino. I roto i tenei take te tikanga "Cefepime" ngā pūmau ki te paparetanga i beta-lactamases (pūira) C-piha. Na reira, motu ke i nga āhuatanga i rawe ki ki cephalosporins whakatupuranga 3 (te tikanga "ceftriaxone" "Cefotaxime"), te whakaatu tarukino taua āhuatanga rite:

• pānga i runga i koiora overproducing beta-lactamases (pūira) C-piha;
• whanaunga mahi nui ki microorganisms kore-fermenting;
• (E kore he mārama noa te mutunga te uara o tenei āhuatanga) he ātete teitei ki paparetanga o beta-lactamase horapa tūāwhiorangi.

rongoā Ingibitorzaschischennye

Tenei rōpū ngā kotahi tarukino "Cefoperazone / Sulbactam". I roto i te rite ki te monosredstvom, kua whānui medicament ngā hihinga o mahi. pānga te reira i te microorganisms anaerobic, te nuinga o taumahatanga o Enterobacteriaceae, nehenehe o te whakaputa beta-lactamases.

Pharmacokinetics

Parenteral cephalosporins 3, 4, whakatupuranga o te tino pai whenumi ka whakahaere ki te uaua. Medicaments mō te whakahaere ā-waha āhuatanga e te absorption tiketike i roto i te wahi gastrointestinal. ka whakawhirinaki bioavailability i runga i te medicament ngā. Ko te reira i roto i te whānuitanga o 40-50% (mō taero "Cefixime", hei tauira) ki 95% (mō moni "Cefaclor" "cefadroxil" "Cephalexin"). absorption Oral o etahi rongoā e taea pōturi iho te horomanga kai. Ko te tarukino pērā i "haapae hua Cefuroxime" i roto i absorption hydrolyzed. Ētahi atu tuku tere o te wāhanga hohe ina whakatairanga reira kai.

E pai te tohaina whakatupuranga cephalosporins 4 i roto i te maha te kopa me okana (hāunga te repeure), me te ngaro. I nohanga tarukino tiketike e kitea i roto i fluids synovial me peritoneal, pericardial me pleural, wheua, me te kiri, kiko ngohengohe, ate, uaua, tākihi me pūkahukahu. Ko te kaha ki te haere i te BBB me te hanga i te kukū whakaora i roto i te CSF he atu korerotia i roto i te raau taero tuatoru-whakatupuranga pērā i "Ceftazidime" "ceftriaxone" me te "Cefotaxime" me māngai wha - te tikanga "Cefepime".

Pākia me excretion

Ko te nuinga o cephalosporins kore e ngohengohe ki te pirau. whakaaro He okotahi ko te rongoā "cefotaxime". biotransfomiruetsya aru te reira na roto i te hanganga o te hua kaha. cephalosporins excreted whakatupuranga 4, me te māngai o te tahi atu, te nuinga whatukuhu. A, no te memenge i roto i te mimi e kitea nohanga āhua tiketike.

Rongoā "Cefoperazone" me "Ceftriaxone" āhuatanga e te whakakorenga rua - te ate, me nga whatukuhu. Hoki te nuinga o cephalosporins he i roto i tetahi ki te e rua haora hawhe-ora. hiahiatia He roa te wa e hoki te moni "ceftibuten," "Cefixime" (3-4 haora) me te "Ceftriaxone" (8.5 haora). hanga tenei reira taea ki te tautapa ratou kotahi te ra. I roto i te tūroro ki te täkihi, Me ki te papaki inenga o rongoā.

pānga taha

Paturopi - cephalosporins whakatupuranga 4 - meinga he maha o mau hopearaa ino, tae atu:

• Allergy. kia wheako tūroro erythema multiforme, hikaka, urticaria, mate serum, eosinophilia. pānga te taha o tenei kāwai ngā ano ru anaphylactic, kirika, angioedema, bronchoconstriction.
• tauhohe Hematologic. I roto ia ratou, ko te ki te whakarato i te pai Coombs, leucopenia, eosinophilia (nohinohi te), anemia hemolytic, neutropenia.
• disorders io. I roto i te tono o pota teitei i roto i te tūroro ki te pōrearea tākihi haehae kitea.
• Ate: nui haere transaminases.
• disorders kūnatu. I roto i te pānga kino he korere tino noa, colitis pseudomembranous, ruaki me te whakapairuaki, mamae i roto i te puku. I roto i te take o kumete wai ki nga whatiwhatinga toto hurihia tarukino.
• tauhohe Local. Ko ētahi o ēnei kookuhutanga me tetahi raru i te pae o te werohia intramuscular me phlebitis ki werohia rō-uaua.
• E whakahuatia Ētahi atu pānga i roto i te puka o te candidiasis tara, me te waha.

Tuhinga me contraindications

whakaritea whakatupuranga 4 cephalosporins ka nizkominalnyh taimaha pai mate meinga e microflora multidrug-ātete. Ēnei ngā kiripūkahu empyema, whēwhē i roto i te pukapuka, kakā, te septicaemia, wheua me disorders tahi. 4 E whakaatu ana i te mate whakatupuranga cephalosporins uaua e momo i roto i te mimi, ki neutropenia me ētahi atu āhua immunodeficient. e kore e rongoa i tautapatia ki te ātete kai takitahi.

mehua whakatūpato

I roto i te tono kitea te ripeka-momo mate pāwera. Tūroro kātaki'i o rongoā paturopi tohua te tauhohenga rite ki nga cephalosporins tuatahi-whakatupuranga. pāwera Cross ka tono te kāwai tuarua tuatoru ranei he ngoikore (i roto i te 1-3% o ngā take). Ki te hītori o tauhohe tonu momo (hei tauira, ru anaphylactic , urticaria ranei), o te raau taero whakatupuranga tuatahi e whakaritea ki te tūpato. Ko nga whakatakataka a te kāwai e whai ake nei (ina koa te tuawha) ko haumaru.

Pregnancy me te hohipera

E whakaritea cephalosporins mua i te whānautanga, kahore tetahi here motuhake. Heoi, kihai i rangahau mana tika i runga i te haumaru o ngā rongoā whakahaere. I nohanga iti o cephalosporins taea tomo ki roto ki te waiu. Ko te pea ki te huri i roto i te microflora intestinal, candidiasis, ponana kiri, sensitization o tamariki ki te whakamārama o te tarukino i roto i te hohipera.

Pediatrics me Geriatrics

I roto i te tono o te hou ka whakanui i pea te hawhe-ora i runga i te whakamārama o te inhibition o excretion tākihi. I roto i te tūroro kaumātua, he huringa i roto i te mahi tākihi, na reira me te āta pea i roto i te tango i rongoā. kia rapua e tenei whakatikatikanga tono haaati me te inenga.

pōrearea tākihi

Mai puta tango o te nuinga o cephalosporins matua i roto i te pūnaha tākihi i roto i te puka kaha, kia whakaritea te talena inenga ki whakaata i te āhuatanga o te rauropi. I pota tiketike, rawa i roto i ngā ki Diuretics koropiko, aminoglycoside takanga pea pānga nephrotoxic ranei.

pōrearea ate

E excreted ētahi taero i roto i te ate, me reira tūroro ki te mate ate kino, kia heke te inenga. I roto i enei tūroro i reira ko te keno tiketike mō te toto me te gipoprotrombinemii i roto i te tono tikanga "Cefoperazone". Ka rite ki te mehua ārai tūtohutia huaora K.