He aha te mea te peptides natriuretic?

Ka rite ki i faataa i roto i te mua tata, i roto i te tua ki te mahi kitea ngakau mahi te tūranga o te endocrine okana. whakaohokia te reira i te moni i roto i pūkenga o rongoā kore anake, engari ano hoki i roto i ngā. peptides Natriuretic (NUP) tohua i roto i te myocardium kore anake, engari ano hoki i roto i te maha o te tahi atu whekau, mahi endocrine whakahengia mua. I hanga he whakatau ngātahi ki te whakamahi i ngā tohu ine NFA i te toto mo te matapae o pathologies cardiac, rite ko te iti rawa urutomo me te ngāwari hoki te manawanui tenei tikanga.

Ko te kitea o te mahi endocrine o te ngakau

Kua peptides Natriuretic kitea i roto i te eighties o te rau tau whakamutunga, ka kite kaiputaiao i te hononga i waenganui i te mānukanuka o te ruma ngakau me te kaha o te secretion o mimi. Te kitea whakaaro i te tuatahi ko reira he āhuatanga pūpū, a hoatu ana e ia te tikanga.

I muri mai, ka haere mai i te ako o tenei pātai i Pathologists me histology, kitea ratou e i roto i te pūtau o te kikokiko, wahi o te marae, i reira he inclusions kei roto rāpoi ngota pūmua ratou. Kua Kua experimentally whakamatauria te reira e te wāhanga i te atria o kiore hua te pānga kaha diuretic. Na ka muri i roto i te faatea i te peptide me raupapa o ngā toenga waikawa amino e kėia reira.

Etahi wa i muri mai, kua tāutuhia biochemists he pūmua i roto i te wāhanga motuhake e toru (alpha, peta, me te kama), e kore e rerekē anake i roto i te hanganga matū, engari ano hoki i kaha atu i te tahi atu e rua te pānga o te ārepa kua. kitea tēnei wā:

- NUP Atrial (momo A);
- NUP kaka (momo B);
- urodilatin (momo C).

Biochemistry peptide natriuretic

He rite i roto i te hanganga peptides natriuretic katoa me rerekē anake i roto i te mutunga Radicals nitrogenous whakaritenga o ngota waro ranei. I teie mahana, arotahi aro katoa te i runga i te momo Utaina NUP B, rite te mea he puka atu kainga i roto i wē toto, a hoki ka taea ki a koe te tiki hua atu kōrero. Atrial NFA nui te tūranga o tetahi o nga correctors o te wai me te kawehiko toenga o te tinana. Kei te whakaputaina te reira i roto i te myocardium i noa e rua, me te i roto i te kore te ngakau ma'i.

Kei te whakamatauria te reira e ngā te kawainga o te NUP roro o 108 toenga waikawa amino e synthesized e pūtau o te mānawanawa maui. A, no te te otshnurovyvaetsya muingota i te cytoplasm, te mahi paru pūmanawa kino ki runga ki taua mea, e hanga tenei pūmua i roto i tona puka hohe (32 waikawa amino o te 108). vai NUP roro i roto i te toto o te 40 anake meneti, ka decomposed. Te whakanui ake i te ariā pūmua e pā ana ki te mānukanuka taiepa ventricular ake te, me te ischemia cardiac.

Excretion UNYP i wē whakamana i roto i rua ara matua:

- wāhinga o whākōkī lysosomal;
- proteolysis.

mawehe atu te tūranga ārahi te pānga i runga i rāpoi ngota endopeptidase kūpapa, engari wāhi tikanga e rua ki te whakakorenga o te peptides natriuretic.

pūnaha receptor

E whakamana pānga katoa o peptides natriuretic tika ki ngā ki kei roto i te roro o ratou receptors, oko toto, uaua, wheua, me te adipose kiko. Ōrite ki te toru ngā momo o NFA me i reira e toru ngā momo o receptors - A, B, me C. Heoi, te tohatoha o "ngaahi fatongia" kore pera kitea:

- momo A receptors taunekeneke ki Atrial me NUP roro;
- Ko te momo tauhohe ki urodilatin anake;
- Ka taea e receptors herea ki ngā momo katoa e toru o ngā rāpoi ngota.

E faufaa rerekē i ia atu receptors. E hangaia ana te me te B momo ki te whakatinana i te pānga intracellular o receptors peptide natriuretic me momo C e hiahiatia mō te biodegradation o ngā rāpoi ngota pūmua. He he nounou e kawea te rongo o haaparuparu UNYP i kore anake e te momo te receptor, engari ano hoki ki ētahi atu wahi Tārewa e he aro ki te nui o te monophosphate guanosine huringa.

Ko te tokomaha nui o receptors momo C kitea i roto i te kiko roro, repe adrenal, whatukuhu, me nga oko. A, no te herea UNYP rāpoi ngota ki te receptor o te momo C, e riro te reira e te pūtau me te piri, me te kua hoki mai te receptor noa ki te membrane.

Physiology peptide natriuretic

Brain me Atrial peptides natriuretic faaohipa i to ratou pānga i roto i te pūnaha o ngā urupare whaiaroaro matatini. Ko ratou katoa iku arahi ki te whāinga kotahi - te whakaiti i te preload i runga i te ngakau. pānga NUP te Cardiovascular, endocrine, io puha, me te pokapū.

Mai i enei rāpoi ngota i te marena mo te ngā receptors, te miramira, te pānga o etahi momo o NFA i runga i te pūnaha ngā, ko reira uaua. Ano, tei te pānga peptide i runga i tona momo kore anake, engari i runga i te receptor wāhi Tārewa.

E pā ana Atrial peptide natriuretic ki peptides vasoactive, i.e. he pānga tika i runga i diameter iaia. Ko motu i taua he reira e taea ki te whakaongaonga i te hanga o te waikura nitric e whakatairanga hoki vasodilation. NUP A ko B i te taua momo me te ahunga o te mahi tōpana i runga i ngā momo katoa o oko, me te P-momo nuinga faarahi uaua anake.

Tata nei kua reira kua te whakaaro kia kia mohio a te NFA rite te vasodilator kore anake, engari matua hei enemi o vasoconstrictor. I tua atu, i reira he rangahau e whakaatu e awe peptides natriuretic te tohatoha o te inu i roto i, me te i roto i o te whatunga capillary.

pānga tākihi o te peptide natriuretic

Mō te peptide natriuretic taea te mea e ko te reira i te diuresis stimulant. Matua faarahi momo NUP A rere toto tākihi me whakanuia ana te pēhanga i roto i te oko o te glomeruli. Tenei, i roto i te tahuri, faarahi te filtration glomerular. I te momo wa NUP taua faarahi C te excretion o katote konutai, a arata'i tenei ki mate atu o te wai.

Ki te kore te tenei katoa o tetahi huringa nui i roto i te pēhanga pūnaha kitea, ara, ki te nui haere te taumata peptide e rave rahi taime. whakaae pūkenga katoa e ia faaitoito i te pānga o taua peptides natriuretic i runga i nga whatukuhu, he tika hoki te ako o te wai me te kawehiko toenga i roto i pathologies ma'i o te pūnaha Cardiovascular.

Pānga i runga i te CNS

Brain peptide natriuretic rite Atrial, e kore e taea e ô i te arai toto-roro. Na reira, pānga ratou nga hanganga io kei waho reira. Ko ia etahi o te NFA huna ana e te kiriuhi roro me ētahi atu ona pae.

Ko te pānga pokapū o peptides natriuretic takoto i roto i te meka e whakaū ratou ngā huringa piringa. Ko te kupu, hei tauira, tahi ki te whakaiti i roto i te tinana preload cardiac heke tona hiahia mo te wai me te kohuke tai, ka taui hoki te āhua o te pūnaha io autonomic i te aronga o te wahi parasympathetic.

tohu taiwhanga

Ko te whakaaro o te tango i te tātaritanga peptide natriuretic i roto i disorders o te pūnaha Cardiovascular ahu i roto i te tīmatanga o 90-doma o te rau tau whakamutunga. He tekau tau i muri mai, te mau papai tuatahi ki nga hua o te rangahau i roto i tenei rohe. I korerotia te reira e B-momo NPU kōrero ka aromatawai i te pakeke o te kore ngakau, me te matapae mate haereraa.

whakaritea te ihirangi Pūmua i roto i venous toto katoa, i konatunatua ki te EDTA, mā te whakamahi i te tātari immunochemical ranei. kore me Te tikanga UNYP taumata nui 100 ng / ml. I tua atu, he mea ka taea ki te whakatau i te taumata o te kawainga NFA mā tikanga electrochemiluminescent. rongoā Domestic, e kore he he momo taua o whakamahinga hono anga matou immunosorbent rite he tikanga ao mō te whakatau i te nui o te taonga i roto i te serum toto.

Whakatau i o pōrearea cardiac

peptide Natriuretic (täkupu - ki runga ki te 100 ng / ml) ko tēnei wā te tohu tino rongonui, me te tino hou mō te whakatau i te pōrearea uaua cardiac. I hono nga rangahau tuatahi o te peptides ki te mau fifi o te pārōnaki o ma'i kore circulatory me ma'i mate pūkahukahu taunutia. Mai i rite nga tohu haumanu, tauturu te whakamātautau ki te tautuhi i te take o aorangia hoki, me te matapae i te whanaketanga atu o te mate.

Te māuiuitanga tuarua, kua oti nei te ako i tenei tirohanga, ko te manawa toto pūroto. whakaae nga kaituhi o rangahau e tauturu te whakamāramatanga o NFA taumata ki te whakatū i te tahuti nei tata hohokitanga ranei i roto i te manawanui. I tua atu, i te aroturuki taumata NFA hihiri ko te tohu o te maimoatanga miramira.

I tēnei wā, whakaritea te taumata o NFA te i roto i te tūroro ki cardiomyopathy, takawhita, stenosis o oko nui, me te tahi atu disorders circulatory.

Whakamahia i roto i te pokanga cardiac

Kua empirically kua whakakitea reira e taea te i titiro te taumata o te peptide natriuretic Atrial i roto i te toto hei tohu o te pakeke o te huru me te mahi o te roro ki maui i roto i tūroro i mua, me te i muri i te pokanga cardiac.

Ko te ako o tenei āhuatanga timata i 1993, engari tae anake te tauine rahi i roto i te 2000. I kitea te reira e te heke koi i roto i te maha o NUP i te toto piringa, ki te aroaro o tona taumata kua tonu ake, fokotu'u e heke te mahi o te myocardium te ka ko angitu te mahi. Ki te kahore i whakaiti NFA puta, ka mate te manawanui ki te 100% tūponotanga. Ko te hononga i waenga i te tau, sex me te taumata o te peptide kua tāutuhia, reira, he ao mō ngā kāwai katoa o tūroro tenei ahua.

Waitohunga i muri i te pokanga

I mua i te pokanga nui haere cardiac peptide natriuretic. I muri i te katoa, ki te i te reira te kore, na kihai i te hiahia mō te maimoatanga reira. Ko te taumata tiketike o te tūroro NFA i mua maimoatanga ko te take kino e nui pānga te waitohunga i muri i te pokanga.

Mai i iti te rōpū whiriwhiri mo te ako, i konatunatua nga hua. I runga i te ringa kotahi, whakatau i te taumata o NFA i mua, me te i muri i te pokanga taea tākuta ki te matapae i tarukino me te tautoko taputapu ka hiahiatia kia ki te whakaoti i whakaora o te ngakau o ona mahi. Hoki i ite i te reira e te nui nui haere o te momo NUP B ko te kawainga o te fibrillation Atrial i roto i te wā postoperative.