Ko te tarukino "Carboplatin": tohutohu mō te whakamahi, analogs me arotake

He aha e taea e te whakakapi tenei tarukino rite "Carboplatin"? Ka kia whakarārangitia Analogs o tenei tarukino i raro. Ano i roto i te rauemi o tēnei tuhinga ka e te aroaro mōhiohio e pā ana ki te whakamahi tika o te moni mea, ona tohu, pānga taha me contraindications.

whakaahuatanga Composition, te āhua o te medicament

I roto i te aha puka he tarukino wātea "Carboplatin"? Kerēme te kaihanga e taea te hokona te taputapu rite te puehu lyophilized ma tikanga mo te faaineineraa o te otinga rō-uaua. Ko tōna whakauru kaha he carboplatin, a atu - mannitol.

I roto i te hoko o te werohanga kareti "Carboplatin", te hanganga o nei i te aroaro matou i runga, mai i roto i nga ipu e kua whakanohoia i roto i te pepa tākai.

āhuatanga pharmacological

He aha te mea te tarukino "Carboplatin"? Tohutohu mō te pūrongo whakamahi, urupare e he pūhui pararopi matatini kei roto i te whakarewa taimaha pērā i konukawata.

Tohunga whakaaro e te huarahi o te mahi o tenei taputapu he tika ki tona kaha ki te here ki te DNA. Ka rite ki te hua, i hanga vnutrispiralnye crosslinking whakarereketia hanganga DNA me te tautāwhi i tona kōtuitanga. puta te pānga rite ahakoa o te wāhanga huringa pūtau. Me kï reira e te carboplatin Hydration, i roto i nei i hanga ahua kaha o te tarukino ko nui pōturi ake i te hydration o cisplatin.

tawhā konikoni o te medicament

Kia pehea te e te tinana tangata, ko te "Carboplatin" tohatoha o te tarukino? Tohutohu mō te whakamahi kī e muri i te whakahaere kotahi o tenei kaihoko i roto i te puka o te whaowhia (iv) 60 meneti, i roto i te kukū toto o free (i.e. ultrafiltration Nireaha) me te tapeke heke konukawata i roto i runga i te tauira-wāhanga e rua o te pharmacokinetics kia tuatahi.

Tīmata wa o free konukawata-ora o āhua 2 haora, me te T1 kāpeka / 2 - 3-6 haora. Me mahara hoki käore te reira e te āhuatanga te konukawata katoa e rite tuatahi hawhe-te ora, engari i te mutunga-reira roa (e pā ana ki te ra).

i kitea whakahaere toutou o te tarukino hoki 4 ra i roto i te rarangi i roto i te haaputuputuraa toto o konukawata. I muri i te kotahi ra i muri i te tono o te tarukino e pā ana ki 85% o te whakauru kaha i roto i te wē herea te ki pūmua huru.

Kia pehea te ko te whakakorenga o te tarukino "Carboplatin"? kerēme Guide e ahu mai te faaineineraa e te nuinga whatukuhu (āhua 30% o te horopeta tukua i roto i te puka, nā).

I roto i te tangata CS 60 ml / min me runga ake e pā ana ki 65%, me te 70% o te putanga kia inea te whakamahia mō te 11 me te 23 haora, aua.

Mai te whakakorenga o "Carboplatin" e wahi tata katoa e filtration glomerular, he kukū iti anake kitea i roto i te tubules tākihi, e whakamārama te pūmanawa nephrotoxic iti o te tarukino he mea whakarite ki te cisplatin.

Anticancer tarukino "Carboplatin": iteraa papû

I roto i ētahi wā, whakaatu te whakamahi o te raau taero i raro i whakaarohia? E ai ki nga tohutohu, ko reira hoki te maimoatanga o te pukupuku e whai ake nei:

• mate pukupuku ovarian;
• mate pukupuku taiawa;
• te pukupuku iroriki pūtau i roto i nga tangata, me nga wahine;
• sarcoma osteogenic;
• pūkahukahu mate pukupuku;
• medulloblastoma;
• huamo o te kaki, me te upoko.

Ūhia ki te whakamahi o te otinga whaowhia

He aha e te tarukino contraindications kua "carboplatin"? rāhuitia te whakamahi o tenei tarukino te ki te:

• uma-kai;
• pathologies tākihi nui (hei tauira, CC iti iho i te 15 ml / min);
• hapūtanga;
• hypersensitivity ki carboplatin me ētahi atu rongoā, tae atu ki te konukawata;
• myelosuppression nui;
• mate toto nui, tae atu te hunga kitea i roto i te mua tata;
• i roto i te tamarikitanga.

Hoki ki te tūpato whakaritea tenei rongoā te hoki:

• he werohanga tata;
• rongo waimaerotanga;
• disorders tākihi;
• pōuri hematopoiesis wheua wheua, tae atu i te tikanga i muri i iraruke me te hahau;
• whakamahi whakarara o taero nephrotoxic (hei tauira, "Cisplatin");
• mate whakapeka o viral, fungal me te take mai kitakita.

Medicament "Carboplatin": tohutohu mō te whakamahi

Me pēhea te ki te penei te tarukino anticancer kia whakamahia? E ai ki nga tohunga, e taea te tono i tenei medicament rite te monotherapy, i roto i ngā ranei ki ētahi atu tikanga he pānga rite (hei tauira, i roto i ngā ki "Paclitaxel" teuteu).

I runga anō i te aha te rahi me te wahi paetata te manawanui te puku, te whakamahi i tākuta rerekē dosing "Carboplatin". kia whakahaerea reira e pâmuhia hei whaowhia mo 17-55 meneti.

Me pēhea e whakamahi ahau i te rongoā "Carboplatin"? Ārahi ngā ki te toketaá e whai ake nei o tenei taputapu:

• 100 mg / tapawha mita tinana manawanui katoa ra mo 5 ra;
• 300-400 mg / mita tapawha o te manawanui, kotahi nga 4 wiki.

Me kï reira e te wā i waenganui i whakahaere o te tarukino, i te rahi o te 100 mano platelets / mm me 1.5 mano neutrophils / mm, kia kia i te iti rawa 4 wiki.

I mua a muri tono o te "carboplatin" wai whakahaerenga atu me te mau ana i roto i diuresis i akina atu e hiahiatia ana te.

Ki te he nui te tāoke hematological kia Me ki te whakaiti i te inenga o te tarukino ki 26% āhua ranei te manawanui.

A, no te tino whakanuia ana pathologies tākihi te mōrea o te pānga paitini o te raau taero, a reira whakaiti i te horopeta e hāngai ana i runga i te taumata CC.

I roto i te kaumātua, me te whakahaere i mua i te therapy myelosuppressive, kia heke te inenga i te 22-25%.

I mua ki te whakamahi i, kia whakahaere i te otinga e whaowhia tona te tirohanga ataata i roto i te tikanga ki te whakatau mehemea i reira he tetahi he i roto i tona kara poke ranei.

He aha e taea e uru paura tarukino "Carboplatin"? Tohutohu mō te whakamahi o ngā kerēme e Me diluted tarukino kaha i roto i te kūhuka 5% otinga konutai pūhaumāota 9% ranei. I roto i tenei take kia te kukū kitea 0.5-1 mg / ml.

kia rite te otinga tarukino i mua i tika te whakamahi i te reira, mai te mea e rite ana ki te ra kotahi te ora papa mōrahi o te faaineineraa whakauru.

Hohenga i-pūāhua

He aha te urupare huakore ai te tarukino "Carboplatin"? Reviews e pā ana ki tenei taputapu titau e taea whakapataritari reira te whanaketanga o te pānga kino e whai ake nei:

• whekau gastrointestinal: i roto i 11-12 haora i muri i te whakamahi o te raau taero, kia wheako te manawanui whakapairuaki me te ruaki. mōrea iti o tauhohe hiaruaki te whakamahi i te fariiraa o mua antiemetics, me te whakahaere taratahi o te medicament mo 5 ra, ranei he whaowhia rō-uaua tonu mō ngā ra. Ano, i te tahi mau tūroro tauhohe kino pērā i korere, mamae puku, mumura o te mangai, me te kōroke.
• pūnaha hematopoietic: te whakamahi o pota teitei o "carboplatin" taea pehi i te mahi o te wheua wheua hematopoiesis. Ano, he tokomaha nui o te tūroro tohu kitea o anemia, te kaha o e tei runga i te inenga o te raau taero e whakamahia ana. E mea pinepine tūtaki me pōauautanga haumanu pērā i te mate hopuhopu, kirika, toto me te ru ero.
• NA pūnaha io piringa, me te puku o: i reira ko te tūponotanga ka nui o te whakawhanake neuropathies piringa, me te te whakaiti o reflexes tendon hohonu, rawa i roto i te iwi i runga i te 65 tau. I tua atu, tohu ka taea o CNS disorders mahi. maimoatanga auroa ki rongoā e taea meinga neurotoxicity tāpiripiri.
• Whēkau o whakakitenga: i roto i te whakamahi o te moni ko reira pea e ki te ino rangitahi ranei oti mate o kite, me te mate o te kaha kite i te marama, me te wehewehe tae. te tikanga puta titiro fakafoki mai, me te whakapai ake i roto i te maha o ngā wiki i muri i korenga atu o te tarukino. I roto i te iwi ki te mahi tākihi waimaero, nei i tukinotia ki pota tiketike o te raau taero, kite matapo cortical.
• rongo whēkau: te introduction o "Carboplatin" i roto i te tahi mau tūroro i reira he ototoxicity, e faaite ake i roto i te puka o te rongo mate, me te tinnitus.
• Mate pāwera: kirika, erythematous hikaka, pruritus, tauhohenga anaphylactic, urticaria, hypotension me bronchospasm. kia puta ēnei pānga i roto i te torutoru meneti i muri i whakahaere tarukino. Hoki, i roto i wā onge, kia wheako tūroro dermatitis exfoliative.
• pūnaha tākihi: te introduction o "Carboplatin" etahi tūroro wheako he hua rangitahi, me te ngawari i roto i te toto tarukino me te tiomimi nohanga. I roto i tenei take, mate whakapeka ki te whatukuhu ko te tino onge. faarahi te mōrea o te nephrotoxicity i runga i te whakamārama o te whakamahi o tenei kaihoko ki te horopeta, me te iwi peratia mua ki cisplatin.
• Kawehiko toenga: hypocalcemia, hypokalemia, hypomagnesemia, me hyponatremia.
• Ate: he hua rangitahi i roto i ngä nohanga bilirubin, ACT me te phosphatase kawakore i roto i te toto e taea te kitea. Iwi e kua tukinotia ki pota tiketike o te tarukino ki autologous transplantation wheua wheua, kite kōtītiti i roto i te ate.
• Ētahi atu tauhohe: syndrome hemolytic-uremic, rohirohi, alopecia, kore ngakau congestive, tohu rewharewha-rite, myalgia / arthralgia, mate pāwera, disorders iaia roro.

mōhiohio motuhake

He aha tūroro kia mohio i mua i te whakamahi i te tarukino "Carboplatin"? Tohutohu, tautohe kōrero e taea te kawea te whaowhia o tenei raau anake i raro i te te tirotiro tamau o kaimahi hauora i roto i, e tohunga ana i roto i te maimoatanga o āpiha cytotoxic. I roto i tenei taea aroturuki pānga paitini kōwhiri, tautautefito ki he taimi pota tiketike o te tarukino.

I roto i te akoranga o te therapy ki tenei kaihoko, me te rangatira o te marama e toru i muri mai, kia tūroro whakamahi whakawhānau pono.

Hoki te whakarite me te whakahaere muri o te otinga tarukino tika ki te whakamahi i kai hauora e kore e e roto i konumohe. Ko e tika ana ki te meka e ka pähekoheko te reira ki te hohenga tarukino i hanga te ka tohua whakaiti i roto i te te aonga tarukino tenei.

I roto i te maimoatanga, "Carboplatin" hiahiatia whakamātautau neurological wā, tae atu te iwi ruhiruhia, ka tukinotia mua ki cisplatin.

Whakamahi o tenei rongoā kia arahi ki te whanaketanga o ngā pānga ototoxic, a reira kia kawea te maimoatanga-mua i roto i whakamātautau audiometric.

I raro i te mātakitaki o te hauora nui maumaui o te rongo kia hiahia te horopeta whakatikatikanga "Carboplatin" ranei tona Tuhinga oti.

Ki te tomo te hua te kiri kanohi ranei, horoi tonu ki te nui o te wai. Ki te horomia, ki nga tikanga e tika ana te whakatutuki mo te tokoni tohu.

raau taero e rite

He aha analogues tarukino taea te whakakapi "Carboplatin"? Tohutohu mō te whakamahi e kore e roto i te faatura tenei i roto i kore mōhiohio. Muri reira ka whai koe ki te tahuri ki te tākuta mātanga. Ka rite ki te tikanga, tūtohu tohunga te whakamahi o enei analogues "Carboplatin" "Tsitoplatin", "Teksalok", "Displanor", "Oksiplat", "Oxaliplatin", "Platinol", "Cisplatin", "Eloxatin", "Platikad", "Plaksat "" Oksitan "," Oksatera "," Ekzorum ".

Reviews o raau taero anticancer

Na e matau ana koutou he aha e hiahia ana koe i te tarukino pērā i "Carboplatin" ( "Carboplatin Teva"). Tohutohu mō te whakamahi o tenei tarukino kua hoki kua whakaahuatia ana i runga.

Te aromātai o tūroro te tāoke me te aonga o te tarukino "carboplatin" he i tautohetia. kōrero ētahi iwi e pā ana ki te hua pai te maimoatanga o ngā mate pukupuku, me te tahi atu rawa maha whakahua nga pānga paitini o raau taero i runga i ngā whēkau tangata me ngā pūnaha, me te tahi atu ari ino. mea Tohunga e te whai pānga ai ki te kātakí manawanui takitahi o te taonga tarukino kaha, me tona huru whānui. I roto i tetahi take e rapu e hahau mate pukupuku. Ki te kore te mea e tika ana mo etahi take ranei tetahi atu i te tarukino "Carboplatin" te manawanui, ka te whakakapia te reira ki analogs. E āwhina ana tēnei raau whakakapinga antitumor i 90% o te wā.