Rongoā paturopi "zyvox": tohutohu mō te whakamahi, analogs

I roto i te maimoatanga o kitakita mate tākuta te tikanga whakahau paturopi. Ēnei taero i te maha nui o ngā momo. O te akoranga, nga mea katoa o ngā hua rongoā rongoā e taea ki te mohio, engari etahi rongoa ki mate kitakita e o ngā moni.

Ko tētahi o paturopi hou, aroaro nei i roto i to tatou mākete o ngā rongoā - he "zyvox". Tohutohu mō te whakamahi o te raau taero tohu e tenei kaihoko antimicrobial o te take mai waihanga. no reira ki te rōpū motuhake - oxazolidinone. Ko te whakauru matua kaha he linezolid. pānga o te tarukino "zyvox", tohutohu mo te whakamahi, analogs, pānga taha me contraindications: Next kua ka kia whakaaro tatou i te mōhiohio e whai ake nei.

I roto i te mea puka hua te?

E wātea ana i roto i te puka inenga e rua te tarukino:

• I roto i te puka o granules, kua oti te ma kowhai i roto i te tae, me te ki te hā karaka ranei. O enei, he pereoralnogo otinga mo te whakamahi ki te tumanako e ka i roto i 5ml o whakatārewatanga oti 100 mg o linezolid. I whakanohoia nga granules i roto i te kaha ngokingoki o 150 ml. i roto i te mōkihi hoki kua he koko whanganga ki ngā whakapōtaetanga (2.5 me te 5 ml o te whakatārewatanga).
• I roto i te puka o papa kei roto 600 mg o linezolid. Ko te mōkihi he namunamu ki 10 papa i roto.
• otinga e whaowhia kei roto 2 mg linezolid / 1 ml, i roto i pōkai o 100, 200, 300 ml.

He aha te mea te pānga pharmacological o te tarukino?

taonga linezolid Hohe kua te kaha ki te tomo ki roto ki te pūtau kitakita, ki herea ki ratou ribosomes me tautāwhi i te kōtuitanga pūmua. Ka rite ki te hua, te microorganisms e patua.

Ki tetahi microorganisms āwhina tarukino?

Drug "zyvox" ā-ako e tahi ia mōkihi ki te rongoā e tōtika mahi i runga i te microorganisms e whai ake nei:

• huakita takohe Gram-pai: Enterococcus, Corynebacterium, Staphylococcus, streptococcus;
• Gram-kino huakita takohe o te Pasteurella puninga;
• Gram-pai huakita anaerobic: Clostridium me peptostreptokokki;
• huakita anaerobic Gram-tōraro prevotella puninga, bakteroides, chlamydia.

Hei linezolid huakita tika haria o te puninga Moraxella, Legionella, Mycoplasma.

He hoki microorganisms e whakaatu ātete ki linezolid, he wahi o te tarukino "zyvox". Tohutohu mō te whakamahi tohu nga taumahatanga ātete e whai ake nei o: huakita kukuti, me te tuku enterobakteriatsea, nizera me Pseudomonas.

I roto i te mea mate kua whakaaturia reira te rongoa?

Rongoā paturopi "zyvox" whakaritea te mo te mate e whai ake nei:

• mate hopuhopu, me te inflammatory e kua meinga e te huakita e te hunga tairongo ki te tarukino homai.
• I roto i te wā o te hota nosocomial riro-hapori ranei.
• Ki te pāpaka hopuhopu o te kiri, me te kopa ngohengohe o te tinana tangata.
• I roto i te aroaro o mate, āpiha nei he enterococci whakaahua ātete ki vancomycin.

Hoki, ka taea te whakamahi "zyvox" paturopi rite te wāhanga o te momo ngā o te therapy ki mate puta tika huakita ki karamu-tōraro.

pharmacokinetics

āhuatanga Linezolid e absorbability tika tere i te wahi kūnatu ki te awa toto, ahakoa o te kaihoko puka tuku. Kua muri 2 haora i muri i whakahaere o te raau taero, tona kukū i roto i te wē tae te mōrahi. āhuatanga Linezolid e te bioavailability tonu, me te hohoro ko tona tohatoha i roto i whekau me te kopa. Ahakoa o te mea te kukū o paturopi i roto i te toto 31% herea ki pūmua wē.

I roto i te tangata, metabolized te linezolid e hāora ki te hua e rua kahore e nei whai mahi antimicrobial. E excreted ratou e nga whatukuhu (tata ki te 50%) me te paru (ki runga, ki te 6%). Whakatika ki te 35% paturopi kore-metabolized excreted ki mimi.

Tohua e te pharmacokinetics pūmau, āhuatanga nei i te te tarukino "zyvox". Tohutohu mō te whakamahi i runga i te kore o te whakamātautau tarukino i runga i tau o te manawanui rānei. Na reira, e kore e te ruhiruhia rapua e te urutaunga o te inenga o te hua ho'oraa.

inenga

Ko te medicament "zyvox" kia whakaritea ki te tākuta ki te manawanui hoki whakahaere ā-waha ranei i te puka o te whakahaere e whaowhia rō-uaua. Ano, e taea te whakawhiti te manawanui i tetahi momo ki tetahi ingestion i waho ngaro te whai huatanga o te maimoatanga.

Medication inenga, roanga o te akoranga me whakatakoto e te rata, me te maimoatanga o enei huru e meinga e te āhuatanga e whai ake:

• he aha te ahua o huakita i meinga e te mate;
• mate paetata;
• te pakeke o te mate;
• painga haumanu i te therapy.

A, no te streptococcal kakā, riro-hapori , me te hōhipera-momo i roto i ngā pakeke me ngā tamariki i runga i 12 tau i whakaritea 600 mg o "zyvox" tarukino. Manual tohu e tango i te horopeta o rongoā kia whakatinana nga 12 haora, me te roanga akoranga ko te 10-14 ra.

Hoki mate o te kiri te kopa ngohengohe ranei, uaua ngāwari ranei meinga e staphylococci, streptococci me enterococci ātete ki vancomycin, tae atu syndrome waewae huka (kahore te tapû-) whakaritea horopeta "zyvox" 600 mg. kōrero hoki te ako e te wā i waenganui i tango i te rongoā kia 12 haora. Ko te akoranga o te maimoatanga pumau 10-14 ra, engari kia muri ake ki te 28 nga ra i runga i whakahaunga hauora.

Ki te he waimaero tākihi te manawanui, te whakatikatika horopeta o rongoā me ia. I roto i ngā tukanga tātari toto nekehia atu linezolid te i runga i te wā wā 3 h. I roto i te hononga ki tenei, kia te tarukino kia tangohia i muri i te hui i runga i te purenga o te toto. Tūroro e pāngia ki te kore ate, a kahore e rapu utu i te urutaunga o te inenga.

Tūroro muri atu i te 12 tau tau faataahia te ki te ahua o te tarukino whaowhia "zyvox" anake. Ako mō te whakamahi i roto i nga kohungahunga, me tamariki tohu e kia riro te linezolid i roto i te inenga o te 10 mg / taimaha tinana kg o te tamaiti i te auau i roto i nga 8 haora. Ko te akoranga o te maimoatanga i te 10 ki te 14 nga ra. Ko tēnei inenga o te tarukino ki therapy wā i roto i whiwhi-hapori, me te nosocomial kakā, mate kiko ngohengohe, me te kiri, me te ki te mahi ki mate enterococcal.

takotoranga paruru hanga o konumohe, kua nekehia tonu i mua ki te tukanga e whaowhia. He mea tika ki te tirohia i te mōkihi mō ngā turuturu i te pēpēhinga reira mo te 1 meneti. tākai turuturu taea e tika ana ki te sterility-kore. whakahaerea ana te otinga e whaowhia te i runga i te wā wā o 30-120 meneti.

Āhuatanga o te tono

He ētahi āhuatanga fariiraa "zyvox" tarukino. Manual tohu e ki te meinga te mate e Gram-kino huakita, he mea e tika ana ki te hono atu taero ki mahi ki tenei rōpū o microorganisms.

A, no te fariiraa i linezolid kia puta te tahi mau tūroro myelosuppression reversible. Tei runga i te roanga o te therapy āhuatanga e anemia, leukopenia, thrombocytopenia pancytopenia ranei. I runga i enei raraunga, kia aroturuki kaute toto e whakamana i roto i te tūroro ki te mōrea o te toto. Ano, he tika enei mehua, ki te i te manawanui he hītori o te myelosuppression ranei e ia taero e whakaiti taumata o pūtoto, me platelets ranei ratou mahi. He tika i roto i te wā maimoatanga auroa (14 ra) hoki aromatawai o kaute toto.

kia ētahi tūroro te fariiraa i linezopida kia haere tahi e te mōrea o te colitis, pseudomembranous āhua o ngā momo rerekē o te mahara.

He noa i roto i te iwi tango paturopi pinepine korere. Ko te whānuitanga o tenei pānga taha kia rerekē i ngawari ki kino. I tango te raau taero, "zyvox" pire whakatārewatanga ranei ko, i reira he pehanga o microflora intestinal noa me te ururua hoki o huakita o te puninga Clostridium. I roto i te tukanga o ratou ora tenei kaiao hua tāoke A me ngā rōpū B, a meinga ana e ratou korere. taumata teitei o enei wāhanga taea e mate mō ngā tūroro. tūroro katoa hunga i pehia tenei momo o te korere, Me te tirotiro hauora tupato mo te wā o te 2 marama.

I roto i ētahi wā, he ino i roto i te maimoatanga o te tarukino "zyvox". Tohutohu mō te whakamahi i roto i ngā tamariki me ngā pakeke, e tohu ana i te huringa taea i roto i te tirohanga tae, arotahi ataata, melé mara, te peroo. I roto i enei take, kia kōrero tonu i te manawanui tākuta kanohi. Ki te tangohia tenei rongoā e te manawanui ki runga o te wā (neke atu i te 3 marama) he wā roa, ka ko reira whakahauanga ki te hanga i te mana o. I tupu me te whanaketanga o ngā pērā i neuropathy piringa io whatu ranei, te pātai o te mutunga o te therapy tarukino ki te painga i reira he iti iho i te kino i mea ai ki te hauora.

Ano, i reira nga take o te acidosis lactic i tango "zyvox". faaite te reira i ano i roto i te puka o te whakapairuaki, ruaki, acidosis ranei whakaiti ore o ng ngota pākawa waro. Me āta aroturuki tēnei āhuatanga mātanga hauora.

Ki te mea he hiahia i roto i te taha ki te "zyvox" tango whiriwhiri inhibitors serotonin reuptake te manawanui, kia tangohia ai i raro i te tirotiro hauora i roto i te tikanga ki te kitea serotonin syndrome: he kore o te mahi hinengaro, hyperreflexia, hyperpyrexia, me incoordination. I roto i te aroaro o nga tītohu whakaahuatia hua korenga atu o tetahi ranei e rua taero. Ko te kupu i reira ko te discoloration o niho i tohu, nekehia atu nei e horoi ngaio.

Tera atu ano tetahi arai ki te riro "zyvox" tarukino. Tohutohu mō te whakamahi (papa reira granules mō te whakatārewatanga ranei - e kore e mea faufaa) kī e: e kore te te maimoatanga ki linezolid peia waka, te whakahaere taputapu motuhake, me ngā mahi e whai wāhi mai mōrea ki te ora, me te hauora tūtohu.

He aha e nga pānga taha o te tarukino?

tauhohe kino e kia puta i roto i te manawanui i tango o te kaihoko ho'oraa "zyvox 600 mg" whakarōpūtia e te oraraa o te auautanga i te tino pinepine (10%) ki te tino onge (0.01%).

Tikanga, te pānga taha i roto i te maimoatanga o te tarukino "zyvox" tohutohu mō te whakamahi, tenei otinga papa ranei, tītohunga huaina te pakeke ngawari āhua ranei. He nga huanga e whai ake nei auau Motuhake:

• whakapairuaki;
• korere;
• pāhoahoa.

I roto i te tūroro pakeke kia wheako hoki kōroke, ruaki, te mamae i roto i te puku, bloating, me mate vulvovaginal o te kōhao-waha.

Na roto i te uaua e puta ana ngā pānga taha o te tarukino "zyvox" tohutohu mō te whakamahi (mō ngā tamariki i runga 12 tau, me ngā pakeke) karanga te huringa i roto i te tae o te reo o te tae.

I runga i ngā akoranga taiwhanga, e taea te tohe i te reira e i roto i te maimoatanga ki tenei rongoā paturopi te maha kitea thrombocytopenia. E kore e pera auau kitea hua i roto i ngā taumata toto o pāhare, whakahohenga rerekē o te ate pūmua whākōkī ALT, AST, phosphatase kawakore, LDH me lipase me amylase. hua i roto i te kukū o te katoa bilirubin, creatine me prolactin tuhia hoki.

Ko te pūnaha io o te manawanui kia huru ki te tarukino ki linezolid. Kei te maha whakahuatia tenei i roto i te taninito me migraines, me te cramps. faaiteraa e ono o pānga taha tarukino he take pangia e anuanu.

Huringa i roto i te mahi noa o te pūnaha io pokapū taea meinga "zyvox" (papa). Guide tohu ohoroa tino noa i roto i te tūroro i roto i te akoranga o te maimoatanga ki tenei faaineineraa ho'oraa.

Ka taea te kitea te mahi o te therapy pūnaha genitourinary te whakamahi i "zyvox" i roto i te puka o te candidiasis tara.

E mea pinepine i reira me te waihakihaki faaiteraa o te maimoatanga linezolid i te puka o rashes.

I roto i te tahi atu ngā pānga taha e taea te huaina ari febrile me mate fungal kapo, e puta pinepine.

Ano, kitea ka tarukino "zyvox" ako i take o te pēhanga toto tiketike, minamina me te tokopā.

Linezolid i roto i te maimoatanga o te tūroro taiohi 12 ki te 17 tau te pakeke, maha kitea nga pānga houhou e whai ake nei:

• korere, ruaki, whakapairuaki, mamae puku;
• taninito, migraine;
• ponana;
• mate hopuhopu o te Airways, mare, nui korokoro runga;
• kirika;
• mamae e te mea uaua ki te whakaahua i te localization.

Ka taea e hua ana hoki huru no te ari whai i te auautanga o raro:

• eosinophilia;
• whakanui i roto i pāhare, ALT, lipase me te creatine;
• apohia e.

i kitea pānga taha atu i te ako haumanu, āhuatanga nei i te "zyvox" (otinga, me papa). Ko ētahi o ēnei:

• myelosuppression reversible;
• neuropathy o te faatae te;
• anaphylaxis;
• pūāhua edema angioneurotic;
• acidosis lactic;
• pūāhua neuropathy piringa;
• discoloration o niho i tohu;
• Chills;
• rohirohi;
• syndrome serotonin.

Ka rite ki "zyvox" te ngā reira ki ētahi atu rongoa?

A, no te tahi-whakahaere ki te cytochrome kitea kahore huringa i roto i te mahi whakamutunga.

Ki te i te wa ano tukinotia ki linezolid me monoamine oxidase inhibitors, whakarei te pānga muri te. I runga i tenei meka, he mea e tika ana ki te whakaiti i te inenga o agonists me Dofaminomimetiki.

A, no te tahi-whakahaere tarukino "zyvox" me pōuritanga e tautāwhi i te hāpainga o te serotonin, kia puta serotonin syndrome.

I roto i te take o te tahi-whakahaere ki "aztreonam" ranei "Gentamycin" farmakinetika linezolid kihai i kitea.

Co-whakahaere ki "Rifampicin" ngā tukupu te makismalnaya kukū "zyvox" - ki runga ki te 32%.

contraindications

he Kāore hoki te whakamahi i ngā tūroro ki nui haere te tūtohutanga ki matua atu ranei wähanga i roto i tona hanganga te tarukino.

Ki te tango te manawanui phenelzine isocarboxazid ranei, linezolid ka taea e kore e tangohia ai i roto i te therapy, a te 2 wiki muri.

Ki te kore koe e taea e te whakahaere i te pēhanga toto, te "zyvox" Kāore ki te hamani tūroro ki te mate e whai ake nei:

• takawhita iu;
• hyperthyroidism;
• pheochromocytoma;
• me te te fariiraa tahi ki agonists me Dofaminomimetiki.

I eita o te mātakitaki tupato o te manawanui ki te mōrea o te serotonin syndrome "zyvox" e kore e taea te whakaritea i roto i te mau huru e whai ake nei:

• aroaro mate carcinoid;
• whakahaere o te raau taero e tautāwhi i te reuptake o serotonin, triptans pōuritanga tricyclic momo "Miperedina" me "buspirone".

contraindicated puka Tablet "zyvox" Kei roto i ngā tamariki i raro i 12 tau no o te eita o kōwhiringa o tika inenga.

Kei te tohuhia te maimoatanga mo te maimoatanga i te mea ko te painga e tumanakohia ana e nui atu i te raruraru i roto i nga take e whai ake nei:

• Te mate kino me te mate pukupuku;
• Nga mate pukupuku;
• Te wa hapu me te taaka.

Ka taea e te tipu o te tarukino te puta?

I roto i nga whakamatautau haumanu, me te whakamahinga ano o te Zyvox ki te hohipera, ki nga take-waho----------------------------------------- Mena ka puta mai taua ahuatanga, ka taunakihia kia mahia te rongoā tohu.

Nga tikanga mo te rokiroki me te wehe

Ko te tarukino "Zivox" e hokona ana i roto i te rongoā mo te tono a te taote. Kia mau ki te wahi kaore i te makuku me te ra i te wera o te rangi e kore e neke atu i te 30˚C, hei whakaiti i te whai waahi o nga tamariki.

Analogues

Ki te kore e whakaaetia te maimoatanga ki a Zivox, ka tohua ana nga analog i te whakaaro o nga paanga o te mahi o te taonga matua matua:

• Te pneumonia me te bronchitis - Doxycycline hydrochloride, Bronchorus, Arlet.
• Ki te mate pukupuku - "Levomycetin 0.25 g", "Vankomabol", "Lifaxon."
• Ma te mate o te kiri - "Benzatin benzylpenicillin", "Sulfadimetoksin."
• I te kore o nga mate whakaora - "Te tote o te konutai a Tsifaleksina", "Lifuzol".

Ko te tohu i te tarukino i ta raatau waarangi ko te kaitautoko anake, no te mea he tohu tohu a tena mo ia maimoatanga, nga ahuatanga o te awhina, me nga whakapae.