"Boudin" inhalation: tohutohu mō te whakamahi, whakaahuatanga, hanganga me arotake

I roto i te maimoatanga o te huangō arahau ki agonist beta-blockers e whakamahia whānuitia corticosteroids hau e whakaiti i te auau me te pakeke o wāhanga o bronchospasm. I roto i tenei rōpū o taero ko ki te whakarato "Boudin" mo te inhalation. i runga i te tono o "Budenita" ā-ringa kei roto ngā mōhiohio taipitopito i runga i te whakamahi o te raau taero, na te utu tatou whakarongo ki te whakaaro o ona āhuatanga matua me motuhake e hangarau o te tono i roto i nebuliser therapy.

tikanga Composition "Boudin Steri-Neb" (whakatārewatanga)

Ako tohu e te tarukino ko te whakatārewatanga hoki inhalation, kowaiwai o te tae me te kakara, Kikī ki oko polyethylene o 2 ml, kei roto 1 mg (0.5 mg / ml) ranei 0.5 mg (0.25 mg / ml) te budesonide whakauru hohe. pā ana tēnei rauemi ki te rōpū pharmacological o hormones glucocorticoid mo tono wā.

pharmacodynamics

Ka rite ki taunakitanga o te tarukino "Boudin" ako mo inhalation, budesonide (te whakauru matua kaha) he anti-mate pāwera, anti-inflammatory me anti-edema pānga. Na roto i te whakaongaonga pūmua lipocortin hanga budesonide he pānga inhibitory runga phospholipase te kōtuitanga, i roto i te tahuri arata'i ki te hekenga i roto i te kōtuitanga waikawa arachidonic, whakaiti i roto i te hanga o prostaglandins me leukotrienes. Ēnei tukanga i arata'i te taumata pūtau ki te whakaiti i roto i te cytokine production, whakaiti i te hekenga o macrophages ka arahi ki te hekenga i roto i kookuhutanga pūtau. Te mutunga iho arata'i tenei ki raro taumata o kaitakawaenga inflammatory e whakaata ana pai i runga i te uhi patua huangō arahau, me te stabilization o tona akoranga haumanu.

Ka rite ki taunakitanga o te tarukino "Boudin Steri-Neb 'tohutohu mō te whakamahi, tona whakamahi auau arata'i ki te faaho'iraa mai o te tūtohutanga o te rakau arahau ki taero, dilates te bronchi. Tenei i roto i te tahuri whakaiti te tini o te whakamahi hou, te whakaiti i te nui o hangaia secretion arahau sputum, te whakaiti te tūtohutanga ki allergens, ano nei he pānga pai i runga i te akoranga haumanu o te mate.

Te raau e kore mahi mineralocorticoid, a kua kahore pānga pūnahanaha e tika ki te mahi rohe, e heke te auau me te pakeke o ngā pānga taha pai noatia hoki te whakamahi roa.

Ka rite ki te medicament o "Boudin Steri-Neb" ā-ako, analogs o te tarukino me te e pai noatia a kahore e meinga te takanga o ngā pānga taha e pā ana ki te whakamahi i corticosteroids pūnahanaha.

I muri i te tono kotahi o te pānga haumanu whakawhanake i roto i te torutoru haora, pa tonu faaiteraa mōrahi i muri i 1-2 wiki i muri i te timatanga o te whakamahi. Ka taea te tōtika te whakamahi i te tarukino mo te ārai o te huangō ahotea tinana arahau, engari e tika ana ki te wā roa moe, te tīmatanga o te mahi whakaora i whakaritea e kore e tika ana mo te tanga o ngā āhuatanga whakapeka e pā bronchospasm.

Pharmacokinetics

whakahaere te raau e te whakamahi i te nebulizer. e mutu ai Kia hau kohu pai budesonide i runga i te mata o te rakau arahau. Mō 15% o te tarukino tika ki absorption i roto i te lumen arahau tomo te tohanga nahanaha, me te metabolized atu mā te whakamahi i te pūnaha cytochrome ki metabolites tata hohekore (ratou mahi ki runga ki te 100 nga wa iti iho i te mahi o te rauemi tīmata). Mō 70% o te raau taero excreted e nga whatukuhu e tikanga o, a excreted e pā ana ki 10% te roto i te paru.

Tuhinga

Ka rite ki e whakaaturia te budesonide tarukino taketake, me ona analogues mo te maimoatanga me te ārai o whakaeke huangō, te memeha noa o te whakamahi i agonist peta-adrenergic whiriwhiri mo te ārai o te mate me te stabilization o pikitia haumanu, me te ki te whakaiti i te pota haumanu o āpiha glucocorticoid-waha. Kua te raau kua whakamahia pai mo te maimoatanga o te laryngotracheitis stenotic me ma'i mate pūkahukahu taunutia.

contraindications

"Boudin Steri-Neb" (whakatārewatanga hoki inhalation) contraindicated te i roto i te aroaro o tauhohe mate pāwera ki tetahi atu ranei wāhanga o te hanganga o te raau taero, me te tamariki i raro i te tau o te 6 tau. Ki te tiaki nui whakaritea te tarukino te mo te mate kohi pūkahukahu, te hinga o Respiratory viral, kitakita, microflora fungal, te ate. Barring te whakamahi o te raau taero i roto i te aroaro o ngā mate hopuhopu meinga e pānga immunosuppressive rohe i runga i te mucous e kia hua i roto i te whakaiti o whakautu ārai me te mate haereraa.

pānga taha

Nā ki te meka i faaterehia te raau e na roto i te inhalation te whakamahi i te nebulizer, te tūponotanga o te takanga o te maroke mucosal o te mangai, me te Airways runga, mana'o korokoro nui, me te ritenga, reka kino, me te rerekē, whango whango ranei, mare. he tika ki te subsidence tarukino mikrochastichek i runga i te mata mucosal tenei.

Tino uaua kitea disorders o te pūnaha io, i faaite mai ratou i roto i te puka o te pau te a nui haere excitability o te neuro-hinengaro, disorders whanonga, pāhoahoa. I tua atu, tūroro tono "Boudin" meinga ētahi wā mate pāwera tuhia rite urticaria, minamina ranei whero o te kiri, spasm o uaua maeneene arahau, me te whanaketanga o te candidiasis o te kōhao-waha, me te pū kai.

Ko te takanga o te bronchoconstriction ihoa me dyspnea ahu whakamua i muri i te tīmatanga o te horopeta tuatahi inhaled tika ki irritating mahi o te tarukino i runga i airway mucosa. Ki te whanaketanga o tenei taha pānga inhalation e tūtohu ana ki te mutu, me te ki te whakarite i tētahi kē therapy.

Ahakoa te bioavailability iti o te tarukino me ona pānga nuinga rohe, kia whakawhanake te whakamahi roa pānga pūnahanaha o glucocorticoids. Ko mahi inhibition whakakitea o te uho adrenal tenei, tērā o te tupu i roto i ngā tamariki, iti i roto i te wheua kohuke kiato, te whanaketanga o maumaui o te tirohanga.

I roto i ētahi wā (uaua) kia meinga ritenga kiri ka whakamahi i te kanohi nebulizer. I roto i te tikanga ki te ārai i tenei pōauautanga kia whakamahia ringihia rongoā mo te kanohi, a muri inhalation o te kiri i raro i rere te wai mahana. Ka taea hoki e koe te tuku i te here mānukanuka rapa pupuri i te kanohi i runga i te mata. He rerekē pai taea te mahi rite te whakamahi o te auvaha auvaha mo inhalation ranei.

Whakamahia i roto i te hapū, me te hohipera

Tohutohu i runga i "Boudin" taunaki ana te tarukino te whakamahi i ki te tūpato i roto i nga wahine hapu, me te i roto i te whāngai ū (ahakoa raraunga i runga i te hua e tomo ngaro i roto i te waiu o te whaea). tūtohutia te tarukino te ki te whakamahi anake ka tami ona painga ki te whaea i te pānga kino taea me pōauautanga ki te kukune. Ko te kupu te mea e tika ana ki te whakamahi i te budesonide whai hua iti i roto i te horopeta e taea hoki te mana tonu o te mate.

taunekeneke Drug

I te taumata o ngā waenganui i te waihanga ho'oraa he hototahi ki te otinga isotonic o te konutai pūhaumāota, me te tahi atu hau beta-agonists, mucolytics me expectorants. I roto i te tikanga ki te whakapiki ake i miramira me te pānga haumanu i spasm whakakapi taero arahau kia whakanohoia tahi ai enei rōpū i roto i te ruma nebulizer. Te faaiteraa i bronchodilators kore anake whakapiki i te rere o "Budesonide" i roto i te rakau bronchoalveolar, engari whai wāhi hoki ki tona kătahi hohonu ki te lumen.

kia arotake No te mea o te whai wāhi o te rōpū pūmua whākōkī cytochrome P450 i te pākia o budesonide horopeta ka whakamahi i taero e lōmekina whakaongaonga mahi o te pūmua whākōkī ranei. E kore tūtohutia tahi whakamahi tarukino ki taero antifungal pērā i "ketoconazole" me "Itraconazole", rite kia arahi tenei ki te hua i roto i te kukū o "budesonide" wē.

Medicaments e whakanui i te mahi o whākōkī microsomal ( "Phenobarbital", "Phenytoin", "Rifampicin") whakaiti mahi "budesonide".

dosing

Tino ohie ki te whakamahi i, "Boudin" mo te inhalation. Tohutohu mō te whakamahi tohu te hiahia ki te whakamahi i te nebulizer mo maimoatanga. whakanohoia te raau i roto i te pūrere nebuliser, me inhales. kia whiriwhiri te roanga o te inhalation me te inenga i roto i ia take tango ki pūkete te huru haumanu o te manawanui, me te pakeke o te mate, ka whakamahi i te tarukino "Boudin" inhalation. Ako mō ngā tamariki i te 6 marama ki te 12 tau tohu ki te whakarite o te budesonide rua te inenga iti. Hoki tūroro pakeke atu i te 12 nga tau, kia whakaritea te horopeta tiaki takitahi.

Ki te tika, "Budenita" i ngā ki taero glucocorticoid waha tūtohutia ki te whakapiki ake i te horopeta o "Budenita" mo te ārai o te tupu, me te whakaiti i te pakeke o ngā pānga taha.

Reviews

Te rongoā rata me tūroro makona aonga o te tarukino. Ka kitea tënei i te arotake o te (whakatārewatanga hoki inhalation Teva «Boudin" - he tarukino tino rongonui) waihanga. i hanga te huru pai pā raro o ngā pānga taha me te maimoatanga tino whai hua. Whakaaro e pā ana ki te "Boudin" waihanga mō inhalation mō ngā tamariki (ako, te inenga i homai i roto i te tuhinga) i te mau metua vahine pai, i te mea ano hoki e tika ana ki te pā iti o ngā pānga taha. korero ano inhalation te whakamahi i nebulizers mamae kore (e taea te whakamana i roto i te whānuitanga o ngā taonga tākaro) i roto i te tamariki taitamariki i roto i te manakohia o te whakamahi o te raau taero, ona analogues ranei.

tuwhena rawa

I roto i te tuwhena rawa whakapeka e kitea nui tohu haumanu. he symptomatic Treatment, ki te whakakāhoretanga o te tarukino me te whakarite o te momo bronchodilator mahi poto-mahi.

kia whanau te reira i roto i te ngakau e ki te whakamahi roa "Budenita" i pota rawa sredneterapevticheskih kia whakawhanake ngā pānga taha i te taumata pūnahanaha (hypercortisolism, korekore o te mahi adrenal). Ka kitea tënei e "Boudin" ako inhalant. E wātea ana hoki te whakamahi wā roa-o te tarukino rite te therapy tuatahi mō te huangō arahau tōna utu.

arata'iraa motuhake me te tohutohu

Tohutohu mō te whakamahi o te tarukino "Boudin" ta e kore te reira hangaia ki te atawhai whakaeke whakapeka o bronchospasm. Ko te wa toharite o te pānga haumanu o e pā ana ki 10 ra, engari e taea te nui haere te reira i te taha o te aroaro i roto i te lumen o te rakau arahau te nui nui o te secretion hūpē Kaore ranei. I roto i tenei take, ko te reira taea ki te whakahaere i te maimoatanga i roto i ngā ki glucocorticoid-waha ki te whakawhitinga i muri anake "Boudin Steri-Neb" inhalation.

Tohutohu ki te raau taero ta e, ahakoa ko nui raro te tūponotanga o ngā pānga taha i te taumata pūnaha, he mea nui ki te ine kukū te horopeta haumanu whai hua mōkito mō te pānga mōrahi. I roto i te faaohiparaa i te raau taero i roto i te tamariki ki te tirohanga ki te tāutu wā o ngā pānga kōaro kia aroturuki tonu tupu o te tamaiti i runga i o te wā he wā roa. Ki te whanaketanga o ngā pānga taha kia heke ki te horopeta whai hua iti, e taea ana ki te whakahaere i whakaeke o huangō.

Hoki te ārai o te mate fungal i roto i te kōhao-waha o te manawanui kia mōhio o te hiahia ki te horoi i te waha me te tango toenga i muri i ia inhalation. whakatairanga ana tēnei faaho'iraa mai o te wātea i te mate rohe me te mucous-waha.

āhuatanga Hangarau Whakamahia

Inhalation "Budenita" te whakamahi i nebulizers ultrasonic contraindicated. kia tātai i te horopeta whai hua o te tarukino tango ki pūkete nga āhuatanga hangarau ngā o te nebulizer (tango ki pūkete te auau rere o te hau, te rōrahi o te nebuliser me t. D.) A huru o te manawanui.

I mua i te whakamahi i te tarukino "Boudin" inhalation nebulizer i roto i te ako nebulizer he whakahauanga kia ako. Ka karo tenei te hononga tano ore o te pūrere, me te whakamahi hauarea o te tarukino. Ki te te whakamahia te nebulizer mo te wa tuatahi, e tūtohu ana ki te whakamātau i te whakamahi i te otinga konutai pūhaumāota whaiaroaro ki te whakarite i tona rawatanga anō me te ka whakamahia ki te taero.

I mua i inhalation ora ake te pouaka ampule kirihou, kua whakatuwheratia reira na roto i te e haehae ana taupoki, whakanohoia te raau taero i roto i te ruma nebulizer o te taputapu, hoatu i runga i te kanohi ki te kanohi (auvaha whakauria ranei) ka whangai ki te rere o te hau. I roto i te hiahia nga inhalations te whakamahi i te waha ki te manawa anake i roto i tou mangai (mau i runga i te ihu topenga motuhake). A, no te te whakamahi i te matehā tono kanohi ihu kōwhiringa topenga.

e tūtohu ana ki te whakamahi i te nebuliser ki te pūrere piha e whakarato werohanga o te tarukino aerosol pai tika i te kau o te inhalation me kati te putanga o te tarukino i te wa o te paunga hoki inhalation. faarahi tenei te tuku tarukino i roto i te rakau bronchoalveolar me te whakaiti i te mate o te rongoā i roto i launoa.

"Boudin Steri-Neb": analogues, utu

analogues Drug "Boudin Steri-Neb" he taero pērā i "Pulmicort" me "Pulmicort Turbuhaler", "Kortimen", "Tafen", "Budoster", "Budenofalk" me te tini ke atu. I enei raau taero, pera i roto i te faaineineraa "Boudin" inhalation, he ōrite te ako e tika ana ki te aroaro o te whakauru kaha taua. utu Raraunga o taero tei runga i te whatunga rongoā me te rohe, me te te inenga. I te toharite, pae te utu i 650 ki te 2550 moni.

mutunga

medicament tino whai hua mo te maimoatanga me te ārai o whakaeke huangō ko "Boudin" inhalation. Tohutohu ki te tarukino homai pārongo āmiki e pā ana ki te inenga, me tikanga o te whakamahi o tenei tarukino. Engari tono budesonide i roto i runga i tohutohu a tūtohutia toketaá o te medicament whakarato he maimoatanga whai hua. Ki te hoki etahi take e kore e taea e koe te hoko i te taketake, i reira he analogues. "Boudin Steri-Neb" (te tohutohu utu e mohiotia nei e koe), ka whakaora koe i maha mate o te pūnaha romahā.