"Fosinopril": tohutohu mō te whakamahi. "Fosinopril": tohu hoki te whakamahi, ritenga tūturu

"Fosinopril" Ko te inhibitor o angiotensin tahuri whākōkī. Kua mahi hypotensive, taea te whakamahi i te reira i te tarukino hoki pēhanga toto tiketike, anake me i therapy matatini. I tua atu, puai te medicament natriuretic, vasodilating me te mahi cardioprotective, kua whakamahia te reira i roto i ngā ki ētahi atu taero i roto i te maimoatanga o te kore ngakau.

āhuatanga pharmacological "fosinopril"

Te faaineineraa "Fosinopril" i roto i te tinana e te ahua o te metabolite hohe e depressing pānga i runga i angiotensin tahuri whākōkī. te whakaiti i te tarukino te auau o te hanganga o te angiotensin 2, normalizes te pēhanga toto nahanaha, pānga pai i runga i nga oko toto.

Angiotensin tahuri mahi paru te whakamahi i 10, 20 me te 40 mg tarukino te nui iti i runga i toharite mō te 7 haora (kahore tere atu i te 2 haora, engari e kore e i muri atu i te 12 haora i muri i tango i te rongoā). I roto i te ra e heke ai e 7-15%.

"Fosinopril" Papa tukua ki te tutakina hypertrophy myocardial me whakarerekē pū o te mānawanawa maui, i whai wāhi te aroaro o taua tikanga ki to ratou whakakorenga. inhibits te tarukino te hanganga o te aldosterone kawea e te atu i roto i te repe adrenal, faarahi te mahi o te pūnaha kallikrein-kinin, ū ai te ihirangi bradykinin i roto i te kopa, me te toto. therapy Nā i runga i te whakamahi o "fosinopril" matū piki liberatiou e whakapai ake te homai toto ki nga whatukuhu, kua natriuretic, mahi vasorelaxant. Ko te medicament whakaiti hanga vasopressin arginine me endothelin-1, e vasoconstrictor mahi.

Na roto i te whakaiti i te pēhanga (diastolic, systolic) kore e whakawhanake, me postural tauhohe tachycardia orthostatic e kore e huri BCC. E kore huringa i roto i te mahi pūpū o te myocardium, tākihi me te rere toto kaka. Kua kahore ofatiraa o te supply toto ki te kiri, whekau, kōhiwi kiko uaua.

Ka rite ki te ā-ako, "Fosinopril" whakamahia i roto i te horopeta kotahi, kua he mahi hypotensive e te tino korerotia i muri e pā ana ki e rima haora. mau te pānga hua te ia ra, e taea ai e koe te pupuri i te tawhā pēhanga toto noa. Hei whakaatu i te pānga taea mōrahi e hiahiatia te ki kua haere i te wiki torutoru.

I roto i te maimoatanga "fosinopril" takawhita taea te whakapai ake whakautu a te tinana ki te hekenga tere i roto i te pēhanga toto pūnahanaha. A, no te ngā therapy ki thiazides me te tikanga "Fosinopril" puta mahi antihypertensive atu korerotia. Ki te tika, te whakakore i te "fosinopril" kihai i whakawhanake i te syndrome, ehara i te mea ara i roto i te take, ka hanga te whakakorenga te tino. whakapiki i takanga te manawanui ka pakeke e rerengia ana puka kore ngakau ma'i, me te whakautu a te tinana ki te ahotea tinana.

No nia i te whakaaturanga o ngā āhuatanga mutagenic me genotoxic i roto i te wā o te maimoatanga whakaatu "Fosinopril" aratohu rongoā ratou ngaro. Heoi, ko te whakamahi o pota cytotoxic arata'i ki etahi disorders e pā ana ki hape pūira. whakakitea Studies i whakahaeretia i roto i te kiore, me te kiore e te horopeta ia e kore rawa 400 mg / e kore e kg meinga tohumate o carcinogenicity. Nā ki pota teitei i roto i te kiore toa te moepuku lipomas maha puta. pota Daily o te tarukino ki runga ki te 60 mg / kihai i kg i roto i kiore meinga disorders e pā ana ki te whakatinanatanga o te mahi whakaputa uri. A, no te whakahaere medicament te kiore hapu (rā horopeta ake ki te 400 mg / kg ia ra) me te räpeti (rā horopeta 40 mg / kg) puta haurangi, raau pēhia te akoranga o te hapūtanga.

tikanga momi āhuatanga rite puhoi "Fosinopril" Taupānga Kaiwhakamahi, e tika ana ki heke atu kai. Na roto i te take o te tuatahi-haere bioavailability pākia paku (36%). "Fosinopril" hydrolyzed, puta tenei tukanga i roto i te toto, ate me te anga gastrointestinal tika ki tona whakatinanatanga fozinoprilat i hanga, i te mea he metabolite hohe. kitea te taumata mōrahi o rongoā i roto i te tinana i runga i toharite toru haora i muri i tona tono. puta hawhe-ora 12-15 haora. Ko tata oti Communication ki te wē - ki runga ki te 98%, he iti te rōrahi o te tohatoha.

Rongoā e kore ofati i te rohe placental me toto-roro tauārai, te wā o te maimoatanga he reira i roto i te waiu uma. I roto i te cirrhosis (waipiro, biliary) heke whakawātea, āta puta paparetanga. I roto i te iti hoki tākihi puta tauwhatinga diatsidnyh metabolites kaha papī, kia kohikohi raau i roto i te tinana. Ko te whakamahi o te tātari, ki te tango i te raau taero i te rauropi "Fosinopril" whakaaturanga ako ā-rite te mahi e kore nei e hua i te hua e hiahiatia ana.

Tuhinga "Fosinopril" teuteu

"Fosinopril" whakaritea mo te kore te ngakau, me te takawhita. I roto i te take tuatahi, ko te tarukino ko te pūtake mo te therapy atu, i roto i te rua i te matatini e whakamahia mō te therapy me te monotherapy.

Maimoatanga ki "Fosinopril"

Tikanga, papa e inu kotahi e rua ranei, nga wa he ra i roto i te wa taua. I roto i te maimoatanga o te takawhita tūtohutia tuatahi 10 mg o te raau taero, a muri mai - 20-40 mg. I roto i te maimoatanga ngā, te kore ka whakamahia "fosinopril" te diuretic, tango 10 mg o tarukino. I roto i tenei take, aroturuki tonu o te pēhanga toto, te horopeta mōrahi ka taea o te tarukino ko 80 mg ia ra. Ki te te raau taero, i tīpokahia te tetahi atu horopeta e kore e whawhati. pota Treatment hua te whakamahi i ngā taputapu tūtohutia e te tākuta e kore e taea te tango i te nui nui iti ranei o te tarukino me te whakapiki ake i tona auau o te whakamahi, e kore e taea te mahi i te whakakorenga "fosinopril", kahore kōrero i te rata.

I mua i te tango i te rongoā tūtohutia "Fosinopril" ā-ringa e whakamatautau koutou te tohu o te hua i roto i te pēhanga toto. I roto i e te whakarite o te maimoatanga ki pūkete te mau huru haumanu rerekē, kia aroturuki auau i te tākuta te huru o te manawanui.

Hei whakaiti i te mōrea o te whanaketanga o te takawhita tuarua, tūtohutia he horopeta iti te i taotoraa. maimoatanga Antihypertensive whakakore whitu nga ra i mua ki te tomokanga o te therapy, "fosinopril". Ki te mea kua whakamana i mua koe therapy diuretic ko ki te whakaiti i te tūponotanga o te hypotension symptomatic, whakatikatika toenga inu, me te kawehiko, diuretic tino whakaiti i te horopeta, i roto i ētahi wā, mutu tango i te tarukino katoa (mō te 4-7 ra i mua ki te horopeta tuatahi "fosinopril").

I muri therapy infarction myocardial tikanga "Fosinopril" ako i runga i te tono taea ki a koe tīmata toru ra i muri mai. I roto i titau maimoatanga inenga auau o te pēhanga toto me ngā tauira Taki o te toto piringa (tirohia i mua i therapy, whakamana mana i roto i 3-6 marama o therapy i roto i te whakaū a muri te tau, kia aroturuki atu auau tika ka he tūponotanga nui o takanga o neutropenia). I tua atu, he mea e tika ana ki te whakahaere taimaha tinana, tirohia te tūnga o nga whatukuhu, me ngā taumata creatinine, pāhare pāporo i te hanganga o te wē pūmua, toto tiomimi hauota. I roto i te maimoatanga e hiahia ana koe ki te whai i te kai.

Tūroro nei mārere takawhita he horopeta rongoā pūāhua āta nui haere (nga po), whakaaro te huringa i roto i te pēhanga toto, i ka te pānga e whakanuia.

Contraindications ki te fariiraa i "Fosinopril" tarukino

A, no te vahe'i papa "Fosinopril" tohu mo te whakamahi e whakaaro tukutahi ki contraindications. E kore te te tarukino whakamahia i roto i te take o te hypersensitivity ki ona wāhanga me ki ētahi atu taero rite. Rongoā e kore whakaritea ki tūroro pakeke iti iho i te 18 tau o te tau, me te wahine e hapu ana, whāngai ū wahine. Kei te kaha Contraindication rerengia täkihi. Contraindications ngā angioedema (idiopathic, tuku) rite te hakari i te wa o te whakarite o te raau taero, me te hunga e whai faaite te hītori hyperkalemia, hypotension.

hapūtanga

opani Papa "Fosinopril" ā-ako te whakamahi i roto i hapūtanga, no te mea e taea taero o tenei momo arahi ki disorders whanaketanga me te mate fetal.

Ki te ko te hapūtanga te wā o te whakatinanatanga o te therapy titau whakakāhoretanga tere o te tarukino. I roto i ngā take pēnei, ki te ako ultrasound tautuhi kino ki te kukune.

He hou i tukinotia i roto i te hapū "fosinopril" nei whaea, e taea te kitea hyperkalemia, hypotension, oliguria. Ki te whakawhanakehia oliguria, he mea nui ki te whakarato i te tautoko mō te perfusion tākihi me te pēhanga toto takina wā. Ki te nga mahi tākihi me i roto i te tikanga ki te haerenga, te pēhanga toto mogzhet kia whakamana huhu tātari ranei.

Whāititanga ki te whakamahi o "Fosinopril" teuteu

I whakauaua e puta mate autoimmune kia tango ki pūkete te ōwehenga o ngā painga me ngā mōrea pea o te maimoatanga tikanga "Fosinopril". Tohutohu mō te whakamahi, tohu whakautu te hiahia ki te whai whakaaro te tūponotanga me painga i roto i te wā e whai ake nei:

• mate te AVC;
• te aroaro o te tākihi manawanui whakatokia;
• kauti;
• mate huka;
• hītori angioedema;
• momo ma'i o te mate pūkahukahu taunutia;
• hyperkalemia ki taupū nui ake i 5.5 mmol / l;
• desensitization;
• cirrhosis;
• huringa taunutia, tahi e te matamua toto waimaero i te ngakau (stenosis te pūtahi o, mitral);
• kore ngakau nui;
• kai, te whakarato i te iti te horomanga o te ihirangi tote o te nui iti o te konutai i roto i te kai pau ranei;
• hyponatremia;
• leukopenia, thrombocytopenia;
• etahi ngā tukanga (tātari, rehunga) mahi;
• atherosclerosis, e pā te wahi o raro;
• maroketanga;
• creatinine täkihi i runga 300 pmol / L;
• koroheketanga;
• kakā;
• raruraru ki te roro, me te rere toto coronary;
• stenosis;
• tikanga i roto i nei whakaiti BCC.

pānga te taha i te "Fosinopril" tarukino

Wātea ki te medicament "Fosinopril" arotake me te aratohu whakaata te tūponotanga o te whakawhanake i etahi pānga taha. Kia puta i roto i disorders o te pūnaha hematopoiesis me pūnaha Cardiovascular. huringa pea o te pūnaha io, pūnaha kūnatu, te whanaketanga o rongo whakahaere. Ētahi tūroro i huringa i roto i ngā tawhā taiwhanga me ngā kino, te faaiteraa kiri pānga, pūnaha musculoskeletal o. Kia puta raruraru i roto i te pūnaha romahā me te urogenital. I roto i te tahi atu tauhohe tinana kino - hyperhidrosis, mate taimaha, ruaki, kirika, edema angioneurotic, te whanaketanga tinana i roto i ngā tukanga hopuhopu tukanga inflammatory i roto i taikiri, lymphadenopathy ranei, te ähua o te mate kauti. kia korerotia tetahi raruraru i roto i te maimoatanga ki tō tākuta. mōrearea Higher o ngā kino e pā ana ki te hē o te raau taero.

Tuwhena rawa "Fosinopril" tarukino

I roto i te maimoatanga whakapōauau, tohu "Fosinopril" whakautu te tūponotanga oraraa o te tuwhena rawa rite ki te hua o rawa te horopeta tūtohutia. tahi tuwhena rawa e faaiteraa whakapeka o hypotension, täkihi, hiamoe, ru, bradycardia, ngangau o te wai me te kawehiko toenga.

Kawea mai te whakaiti horopeta whakakorenga ranei o te puku medicament horoia, ka hoatu ki te inu i te sorbent te manawanui. He mea nui kia tangohia iwi he tūnga whakapae, he mea nui ki te whakatinana i mehua hei whakapiki i te te BCC. Reira titau hoki therapy symptomatic. e kore e tātari toto i roto i tenei take e hoatu te pānga e hiahiatia ana.

Drug taunekeneke "Fosinopril" teuteu

Ko te tūponotanga o te takanga o te hyperkalemia rawa ka whakamahi i taero, tito nei o whakakapi pāhare pāporo tote, cyclosporine, supplementation ki pāhare pāporo, Diuretics pāhare pāporo-tohu.

tau ana faaite mārama atu te pānga o te raau taero i roto i te whakamahi o ētahi atu tikanga, kua he pānga hypotensive, me te waipiro. He pānga ngoikore atu tūmanakohia he hakari rite ki te hua o te whakamahi o ngā matū e whakahohe i te pūnaha renin-angiotensin-aldosterone, estrogen, NSAIDS me sympathomimetics. I roto i te wā, pērā i te mea e tika ana ki te kore ki te farii i enei moni ranei whakakapi "Fosinopril". E tīpakohia e te rata haere Analogs. I runga i te taea o te whakakotahi i te tarukino ki ētahi atu taero e taea te whiwhi i te mātanga.

Analogs, "Fosinopril" taurite tarukino

"Fosinopril" He taurite me analogues. Hoki taurite no "Fosinopril-Teva", "Monopril." Mai i tenei rōpū o taero hua "Fosinopril-OBL», «Fozikard". O nga taurite taea e koe te whiriwhiri "Fozinal", "Fozinotek".

A, no te tikanga o te maimoatanga e kore tukua "Fosinopril" tohutohu mō te whakamahi, taurite analogs ranei whakaritea mātanga mō te maimoatanga. Analogs "Berliprilom ',' Renitec '" ramipril "," Moeksom "," lisinopril ". analogs mohiotia nona hoki "Prestarium", "Enap" me "enalapril". O taea te whakaritea analogues "Tritatse", "Akkupro", "captopril". maimoatanga pea te whakamahi i te "Charter" ranei "Prenessa".

Ki te opani te whakamahi o te rongoā "Fosinopril" tohutohu mō te whakamahi, whiriwhiri analogs taurite ranei whakatau mātanga.

Reviews o te faaineineraa "Fosinopril"

He mea nui ki te whiriwhiri i te tika i te rongoā anti-hypertensive ki te manawanui, tango ki pūkete nga peculiarities o tona tinana. Ki te "Fosinopril" tarukino tangata e tika ana, heke te pēhanga te tōtika, a kahore e nga pānga taha puta. Ka rite ki nga arotake, i reira te mea he stabilization o te pēhanga toto, whakapiki i te hauora whānui. Ki te tauhohe kino o te tinana, me te e kitea, he ngawari ratou, te nuinga pangia e ngangau, Makere, mare.

Ka taea e te pēhanga toto High arahi ki raruraru nui e pā ana ki te kino ki whēkau faufaa, na e hiahia ana koe te wa ki te hanga i te therapy tika, me te pānui i te whakaahuatanga o te rongoā "Fosinopril" analogues, ki te kia maheni ki ētahi atu kōrero whai hua.