Medicine "Cyclophosphamide": tohutohu mō te whakamahi, utu, analogs, kaihanga me arotake

"Cyclophosphamide" ko he pūhui alkylating. Tēnei māngai tarukino antitumor. Kei te hua te reira i rite te puehu ma ranei tata taua tioata. Atu taipitopito e pā ana ki tenei tarukino.

"Cyclophosphamide" - kaihanga

Meinga te raau taero i roto i te kamupene Russian JSC "Biochemistry." Kei roto i te pa o Saransk i runga i te huarahi Vasenko, d. 15.

utu o

Ka taea e koe te hoko i te paura №1 «Cyclophosphamide" i roto i tetahi whare kēmihi. Ko tōna utu he tawhio noa 90-98 moni.

Ko te puka tarukino

Mai i tenei paura, he rite te otinga. Ko te tikanga mo te whakahaere intramuscular me te rō-uaua

āhuatanga hanganga

Ko te hanganga o ia oko ki te puehu ngā taonga momo kaha i huaina "cyclophosphamide". Etahi ko tona tau. Ara kei "Cyclophosphamide" 200 mg o mea taonga ia oko. Tenei hua rongoa kahore excipients.

Whakaahuatanga o te mahi pharmacological

I runga i nga tohutohu mo te whakamahi, "Cyclophosphamide" - ko te tarukino cytostatic alkylating. He rite ki te matū pērā i te hauota pua nani Ko tōna hanganga matū. Pharmacological pānga "cyclophosphamide" ko ki te whakatinana i te momo crosslinking hake i waenganui i te DNA me te RNA whenu. Hoki whakatairanga tenei faaineineraa kōtuitanga pūmua inhibition.

"Cyclophosphamide" - analogues

I roto i tenei take, tangohia ake nga moni e ōrite te waehere ATH kāwai tuawha. Tino moku, ko te "Cyclophosphamide". Analogs o tenei tarukino i reira e he tokomaha. Ko te tino noa:

1. "Endoxane".
2. "Ifosfamide".
3. "Alkeran."
4. "Holoxan"
5. "Ribomustin".
6. "Leykeran".

Ko te kōwhiringa o ia o nga teuteu mahi e te rata i runga i te pūtake takitahi. I roto i tenei take, e te reira ki pūkete te wāhanga hauora, me te kātakí.

I roto i ētahi wā, he?

Kia whai whakaaro ano tatou ki tenei wāhi i roto i te taipitopito atu. Tino moku, ko te whakamahi o te tarukino pērā i "Cyclophosphamide". Tohutohu mō te whakamahi i roto i tenei whakaaro, ko te taputapu mahuinga ia. E kīia ana, e whakaaturia i te raau i roto i te wā e whai ake nei:

1. Ki te wheako koe ma'i, me te whakapeka kanisā lymphocytic.
2. I roto i te aroaro o te myeloma maha.
3. Ki te tohu o te lymphoma kore-Hodgkin.
4. I roto i te kaupapa o fungoides mycosis me retinoblastoma.
5. I roto i te aroaro o te mate o Hodgkin me mate pukupuku ovarian me te uma.
6. A, no te te faaiteraa o tohu o neuroblastoma.

Haunga tenei katoa, whakamahia te raau taero i roto i ngā ki ētahi atu taero āpiha antitumor mo te maimoatanga o te tikanga e whai ake nei:

1. A, no te pukupuku pūtau iroriki.
2. mate pukupuku tōngāmimi, me te pukapuka.
3. Sarcoma o momo kiko ngohengohe.
4. I roto i te kaupapa o te repeure me te pukupuku i te waha.
5. A, no te sarcoma o Ewing.
6. I roto i te take o te pukupuku Wilms '.
7. A, no te retikulosarkome.

Hoki he whai hua rite te momo māngai immunosuppressive ki whakakitenga ahu whakamua o mate autoimmune taua faaineineraa rite "Cyclophosphamide", urupare e he pai,. I roto i tenei take te auraa te ahua o te rumati psoriatic me rheumatoid, autoimmune anemia hemolytic, collagen, syndrome nephrotic. ka mea hoki te tikanga Kōpeke uhi makanga tauhohenga.

contraindications

"Cyclophosphamide" He etahi contraindications. e kore e taea te whakamahi i te reira:

1. I roto i te wā whāngai ū me te hapū.
2. I roto i te ofatiraa i tohua o wheua wheua mahi.
3. Ki te tohu o te hypersensitivity.
4. A, no te whakaroa urination.
5. I roto i te aroaro o mate kaha.
6. I roto i te faaiteraa o te cystitis.

Ko te fakatokanga he tika "Cyclophosphamide", analogues o nei e whakarārangitia i runga ake, e whakahaeretia ana i roto i etahi wā. Ara, i roto i te aroaro o nga mate e whai ake nei:

1. Nefrourolitiaza.
2. mate ngakau kino, ate me te tākihi.
3. Kauti.
4. Puku kookuhutanga o ngā pūtau wheua wheua.
5. Adrenalectomy.
6. Pehanga o te wheua wheua mahi.

Whakaahuatanga o ngā pānga taha

kia whai wāhi "Cyclophosphamide", taurite (analogues) e kua tohua i runga ake, ki te putanga o te pānga taha e whai ake:

1. kia faaite mai i te pūnaha kūnatu tohu pērā i ruaki, whakapairuaki, anorexia, hūhi, stomatitis, mamae i roto i te rohe puku, korere kōroke ranei. Hoki mohio he take takitahi o te jaundice me hemorrhagic colitis.
2. I roto i te mau faaiteraa pūnaha hematopoietic i kitea neutropenia, anemia, thrombocytopenia, leukopenia. I ra kia paku whakaiti 7-14 fariiraa te maha o platelets me leukocytes.
3. I runga i nga faaiteraa kiri o alopecia kitea. Tupu ano makawe i muri i tarukino oti. I tua atu, i roto i te maimoatanga e puta i runga i te ponana kiri. He ai hoki hei te aroaro o te ähua o te huringa kiri, me te titi.
4. I roto i te pūnaha Cardiovascular ka whakahaere pota tiketike o te tarukino i runga i te wā te wā roa kia he faaiteraa o cardiotoxicity. He mea nui ki te mahara. I tua atu, kitea e matou i te putanga o ngā take matatini, me ētahi wā mate, o kore ngakau. Ko e tika ana ki te takanga o te momo myocarditis hemorrhagic tenei.
5. I roto i te mimi e meinga necrosis o nga awa tākihi (tae atu te mate), cystitis hemorrhagic urethritis ranei, kakakīrehe tōngāmimi mimi. I roto i te wā onge, te tono o toketaá tiketike o te tarukino kia puta nephropathy, hyperuricemia me te mahi tākihi. Ko te aroaro o ngā pūtau epithelial i roto i te mimi ai puta.
6. I roto i te pūnaha romahā kia he faaiteraa o te kakakīrehe pūkahukahu interstitial.
7. Ka taea e te disorders pūnaha whakaputa uri puta oogenesis me spermatogenesis, me sterility. tohumate whakamutunga i roto i ētahi wā kia reira tina heke. Ko te nuinga o nga wahine i roto i te tono o te kaihoko kitea te whanaketanga o te amenorrhea. I muri i te maimoatanga, te tikanga ora te auautanga o te waipara. Tangata tango i te tarukino taea arahi ki te putanga o te oligospermia azoospermia ranei, me te taumata o te atrophy testicular.
8. I roto i tenei take e taea te kitea me mate pāwera. Ko te faaiteraa o te hunga ponana kiri, minamina, pununga honé, tauhohe anaphylactic.
9. Ano i roto i tenei take ki reira kia kia te takanga o ngā pānga taha. Ie toto ki te kiri kanohi, whero, pukupuku Tuarua mārere, sweating nui, pāhoahoa.

momo o te pāhekoheko

A, no te fariiraa i tenei tarukino, etahi āhuatanga e whai wāhi ana ki te microsomal hāora i roto i te ate, kia whakatinana tukanga piri microsomal pākia o cyclophosphamide. arata'i tenei ki etahi āhuatanga. Ara, ki te hanganga nui alikiliruyuschego momo metabolites. te whakaiti i tenei te wā mō i kawea te hawhe-ora o te cyclophosphamide i roto i, me whakanuia ana hoki tona mahi. Cyclophosphamide, mārika i te nei roa me inhibits mahi cholinesterase, whakapakari ana te mahi o te suxamethonium. reira tauturu hoki ki te whakaiti i pōturi iho te pākia o te rehukeka ranei. Ka rite ki te hua, whakarei ranei nui haere roanga o tona pānga, me te faarahi te mōrea o ngā pānga paitini. Tenei he pānga tōraro i runga i te rauropi katoa. I tua atu, kia whai wāhi te tono tukutahi o allopurinol ki pānga paitini i runga i te wheua wheua.

A, no te tahi-whakahaere ki te cyclophosphamide allopurinol, colchicine, probenecid, kia hiahia sulfinpyrazone pota ako protivopodagricakih momo taero i roto i te maimoatanga o te kauti, me te hyperuricemia. Ano, ka ai faaite mai tenei hua mōrea nephropathy e pā e te ki nui haere hanga o te waikawa uric te whakamahi i cyclophosphamide.

Ka taea e te taonga o muri meinga he hua i roto i te mahi anticoagulant. Mai tenei kōtuitanga i roto i te ate heke āhuatanga whakatairanga toto upoo- me hanga mōtepe waimaero. Heoi, i reira kia hoki puta te mahi hekenga anticoagulant roto i te momo tikanga unknown.

whakarei ake Cyclophosphamide te cardiotoxicity o daunorubicin me doxorubicin. kia whakapiki ake i te tahi atu āpiha immunosuppressive (chlorambucil, azathioprine, tacrolimus, corticosteroids, mercaptopurine, me ētahi atu) i te taea o te mate tuarua me pukupuku.

Ko te whakamahi tukutahi o lovastatin i roto i te tūroro ki te transplantation ngakau e taea te whakanui ake i te mōrea o mate pērā i rhabdomyolysis me whakapeka täkihi.

Ki te i roto i ngā ki tenei tarukino whakamahia te taero myelosuppressive radiation therapy ranei, he mea ka taea inhibition faaiteraa tāpiri o wheua wheua mahi.

whakahaere tukutahi o cytarabine i pota tiketike ki te rauemi pērā i cyclophosphamide, i te wā faaineineraa ki tukanga transplantation wheua wheua arata'i ki cardiomyopathy ki te whakanui ake auau tīmatanga o te mate.

Ko te paearu matua

I roto i te tono e ki pūkete te whai ake:

1. I roto i te maimoatanga ki tenei raau wā kia kawe i te whakamātautau toto ki te aromatawai i te tohu o te myelosuppression. Ko reira tino tika ana ki te whakarongo ki te maha o platelets me neutrophils.
2. kia hoki auau te maua e koe i roto i te whakamātautau mimi mo te aroaro o te tatau pūtau toto whero. kia whai wāhi ratou aroaro ki te whanaketanga o taua mate rite hemorrhagic cystitis. Ki runga ki te rapunga o taua tohu maimoatanga ki "Cyclophosphamide", te utu o nei whakarārangitia te runga ake, me mutu koe.
3. Ka rite ki te maha o platelets (iti iho i te 100,000 / ml) me / ranei pūtau ma toto (<2500 / L) o te tikanga te fariiraa kia mutu.
4. A, no te tupu mate i roto i te wā o te therapy tarukino, ka mea kia mutu maimoatanga haukotia ranei. Ranei i roto i te take o te fariiraa i te inenga kia iti. Tangata me nga wahine i roto i te tukanga maimoatanga, "cyclophosphamide" he tika ki te whakamahi i ngā tikanga pono o te ārai.
5. I roto i therapy ki tenei tarukino Me ki haapae i te ava.
6. I roto i te take te rano nga wahi tekau nga ra tuatahi i muri i te mahi, i kawea i roto i raro i rehunga whānui, me te manawanui e whakaritea "Cyclophosphamide", te utu o nei whakarārangitia te runga ake, kia whakamōhio koe i te ai ki anesthesiologist.
7. Manawanui i muri i tū ia adrenalectomy, he mea e tika ana ki te kawe i roto i pupuri i te whakatikatika inenga rite nga corticosteroids, e kua whakamahia mō te tukanga whakakapinga therapy, me te tarukino taua, rite te maimoatanga, "Cyclophosphamide".

whakatūpatotanga e tika ana

Ko taea Reception o te raau anake i raro i te mātakitaki o te rata e he wheako i roto i te hahau. kia hoki kia te reira i te hanganga ture tino ki te tikanga inenga. kia meatia tenei rawa i roto i ngā therapy. Ano, e kore e hiahia ana ki te noho i te tuaruatia ai i muri o te horopeta, ki te ngaro te tetahi o mua. I roto i te faaineineraa o tenei tarukino mō te whakamahi i roto i nga kohungahunga e kore e tūtohu ki te whakamahi i diluents e roto i benzyl waipiro. Mai tenei e taea e arahi ki te whanaketanga o te syndrome paitini mate. Ara, ki te ahua o te acidosis pūkoro, CNS korekore, kore romahā, täkihi, hypotension, hukihuki, toto intracranial.

I roto i te akoranga katoa o te maimoatanga tūtohutia te ki te kawe i roto i te huhu toto (1 wa ia wiki 100-125 ml). kia meatia tenei mo te whakaaro o te ārai o mate pērā i hyperuricemia me nephropathy, i te mea e tika ana ki te hanganga o nui haere moni o mua. maha puta ēnei tohu i te timatanga o te wā maimoatanga. Hoki, i mua ki te mea therapy tarukino me te i roto i 72 haora i muri i whakahaere tūtohutia te ki te mahi i te tetahi horomanga inu (e pā ana ki 3 rita ia ra), te whakamahi o te allopurinol (i roto i ngā take motuhake), me te tikanga i hanga mimi kawakore. He tika maha hoki te ārai o mau faaiteraa o hemorrhagic cystitis ki te kawe i roto i te putu i o te tōngāmimi, me te ki te tango "UROMITEKSAN". Ki te reira i tohu tuatahi o te mate, ka mea te rongoa kia mutu faaineineraa ra ano te whakakorenga oti o tetahi tohumate.

Hei attenuate momo ari dyspeptic taea te tango i cyclophosphamide i roto i te ra tuatahi i roto i pota iti. Complete te kanohi ranei alopecia, e kia puta i roto i te maimoatanga he reversible me i muri i te akoranga iti te mahi o te tupu makawe noa. Heoi, kia kia ngohengohe ki te taui i to ratou tae me te hanganga.

Ki te wheako ngā koe Chills, kirika, mare ranei whango, mamae i roto i te rohe o raro hoki, ranei i te taha, urination mamae ranei uaua, toto ranei toto, kumete pango, toto i roto i te kumete mimi ranei kia kōrero tonu i te tākuta.

Ko te taea o te thrombocytopenia, ārahi ki te hiahia mo te tiaki motuhake i roto i ngā mahi pērā i ngā tukanga urutomo me ngā tukanga niho. kia tirohia te reira i wā te kiri, me nga kiriuhi mucous me te pae rō-uaua. Ko tenei i roto i te tikanga ki te kitea tohu o toto. Ko reira tika hoki ki te whakawhāiti i te auau o te venipuncture me te kore i werohia intramuscular. He mea tika ki te whakahaere i te ihirangi toto i roto i feces, ruaki, mimi. Ēnei tūroro ki te tūpato tino me mahi tukanga heu, manicure, dentifrices, toothpicks, me ētahi atu Wāhi I te wa ano kia tino karohia taka me ētahi atu whara. Kei te rāhuitia hoki waikawa ahipirini me te waipiro e whakanui i te mōrearea o te toto gastrointestinal. I roto i tenei take, ko te mea e tika ana ki te whakatinana i te hōtaka roa werohanga (i muri i 3-12 marama i muri i te hahau otinga akoranga whakamutunga). Ko reira e minaminatia ki te karo whakapā ki tūroro hopuhopu. I roto i te maimoatanga he mea e tika ana ki te tono mehua ārai tika.

A, no te whakapā mea tarukino ki te mucosa kiri ranei me ata horoi ki te wai mania te wahi ranei ki te hopi, aua.

Ū me te hapū

He he he fakangatangata moku, i roto i tenei whakaaro, e kua te "Cyclophosphamide". Manual tohu e contraindicated ko te whakamahi o tenei tarukino i roto i te hapūtanga. I roto i tenei take, te kāwai o te pānga i runga i te kukune denoted «D» e FDA. I roto i te maimoatanga he mea e tika ana ki te mutu whāngai ū.

tuwhena rawa

I roto i tenei take, i reira e etahi onäianei. ka mea te aroaro o te raau motuhake ki te tuwhena rawa o he unknown waihanga. Ko te meka pono. I roto i te tono tuwhena rawa me whakatinana mehua tautoko tae maimoatanga tika o ngā mate hopuhopu, me te takanga o te cardiac myelosuppression me / ranei.

tikanga rokiroki

I roto i tenei whakaaro, e titau te reira etahi tikanga pērā faaineineraa rite "Cyclophosphamide". Tohutohu mō te whakamahi pü e me te penapena i te reira i te pāmahana e kore rawa 10 ° C i roto i te wahi e he maroke, me te tiaki i te marama. I roto i te whai wāhi o tenei tamariki ki reira kia whāiti.

ora papa

He he he tetahi wā o te wā i roto i nei e taea te whakamahi i te tarukino pērā i "Cyclophosphamide". Tohutohu mō te whakamahi tohu e tona ora mahi he 3 tau. I roto i tenei take, kia piri koe ki etahi tikanga. takoto te reira i roto i te meka e tino rāhuitia te whakamahi o tenei tarukino i muri i pau i tenei wā.

whakatinanatanga

I roto i tenei aronga, i reira te mea ano hoki he tu'unga e ko "Cyclophosphamide". Tohutohu i runga i te tono tohu e tukua te raau e anake i roto i pharmacies i te whakahaunga.

mutunga

I roto i tenei kuputuhi, i reira te mea he rota o ngā mōhiohio whai hua. A tika te mea ko te "Cyclophosphamide", tohutohu mo te whakamahi, te utu o tenei tarukino. Heoi, kia mau tetahi i roto i te ngakau e te aroaro tono i te tarukino kia kōrero ki te rata tohu.