"Nimesulide": arotake, te whakamahi o analogues

Nonsteroidal āpiha antiinflammatory ko te piha motuhake o taero he nui e toru pānga: antiinflammatory, antipyretic me te analgesic. Nā ki enei āhuatanga pharmacodynamic o tenei rōpū o taero Kei te whānui whakamahia i roto i te mahi hauora. Kia titiro a ki ngā āhuatanga o te tono "Nimesulide" tarukino, mua manawanui e pā ana ki tenei hua rongoa, me te te taea pānga kino me ngā āhuatanga o te dosing.

āhuatanga pharmacodynamic

"Nimesulide" he māngai o te rōpū o kore-steroidal taero anti-inflammatory. I roto i te pā ana tona rōpū tarukino ki te whiriwhiri inhibitors o te paru cyclooxygenase-2, e he whai hua ki te whakatutuki i inhibition o te hanga o prostaglandins i mumura.

Ko tētahi atu āhuatanga motuhake o te huarahi o te mahi "nimesulide" waihanga ko tona kaha ki te tautāwhi i te tuku i te paru i huaina myeloperoxidase, e tino inhibits te hanga o Radicals free i waho e pā i te tukanga chemo- me tigmotaksisa me phagocytosis. I tua atu, "nimesulide" whai wāhi ki te pehanga o te hanganga o te tauwehe puku necrosis me ētahi atu kaitakawaenga whai wāhi i roto i tauhohe inflammatory o te rauropi.

Ko te āhuatanga pharmacokinetic o

He waha te ara matua o te whakahaere o te medicament, e tika ana ki te bioavailability tiketike o te raau taero, auau o te kukū mōrahi i wē o tūroro. Ko te kupu, tutuki te kukū mōrahi te i muri i 120-180 meneti i muri i whakahaere, a ka he tata ki te 98% o te moni "nimesulide" teuteu whakaurua tuatahi te tohu o here o tarukino ki pūmua wē (whakataunga tūroro me rata whakau reira).

Ko te tinana matua i roto i nei te pākia e tarukino ko te ate. I roto i te tukanga o te biotransformation ki metabolite kaha i huaina hydroxynimesulide. Ko te ara matua o te excretion o te tarukino ko tona excretion i te mimi (pera whakaatu e pā ana ki 65% tarukino), excreted e pā ana ki 35% o te raau taero i roto i te tütae.

Tata tūroro katoa i mua i te tango painga o tetahi atu mōhiohio e pā ana ki te tarukino "Nimesulide". Tohutohu mō te whakamahi, analogs, tohu me contraindications, pānga taha - ka ui te tino auau ngā pātai.

Tuhinga

Tuhinga mo te tarukino "Nimesulide" e kore e pera nui. I roto ia ratou he mea utu te tuhituhi mamae whakapeka puta, ki te mamae osteoarthritis tuatahi me te dysmenorrhea tuatahi puta. I roto i te mahi pediatric rite te whakamahi whai hua o te tarukino. Ka kitea tënei i te whakauru i mahue "Nimesulide" tikanga arotake. e kore e tūtohu ana ki te hoko mō ngā tamariki i raro i te 12 tau o te tau - kia mōhio o tenei.

Contraindications ki te tarukino

Ka rite ki contraindicated katoa nonsteroidal anti-inflammatory taero "nimesulide" kei roto i te aroaro o te whewhe pekitīlia ranei koha duodenum (12 whewhe duodenal) i roto i te atamira whakapeka, e tukupu ana te mahi detoxifying ate, i whakatū i te tarukino ki taero hepatotoxic. contraindicated te raau i roto i te tūroro ki te hekenga nui i roto i te puha mahi tākihi (creatinine whakawātea iti iho i te 30 mL / min), disorders hematological me raruraru upoo-, tūroro ki te mahi waimaero Cardiovascular.

"Nimesulide" contraindicated te i roto i te aroaro o te tūroro māuiuitanga hāparapara, metua vahine hapu, me te mea ngote u, a tamariki i raro i te 12 tau o te tau no te mea o te tūponotanga tiketike o tauhohe kino. Ehara i te mea e tika ana ki te tautapa "Nimesulide" mo te maimoatanga o te rewharewha me ngā āhuatanga rewharewha-rite o te tūāhuruiti.

pānga taha

e kore te auraa tenei anake āhuatanga e tiketike mahi anti-inflammatory engari ano te pā nui o tauhohe kino. puta ratou te tikanga i roto i te wiki tuatahi o te therapy ki "Nimesulide". waiho nui ki te kia hiahiatia arotake o te takanga o ngā pānga taha.

E pā ana kiri me te taha kiri pānga ki te mau faaiteraa o tauhohe mate pāwera ki te tarukino me te e kua whakaaturia rite te takanga o te patito kiri me rashes, dermatitis, whero, urticaria. He nui iti pānga taha puta pērā i paitini epidermal necrolysis, Stevens-Johnson syndrome.

I runga i te wahi o te wahi gastrointestinal uaua kia meinga toto, perforation o mariao. More maha whakatika mamae i roto i te epigastric rohe, whakapairuaki, ruaki, korere kōroke ranei.

I runga i te wahi o te pūnaha io pokapū kia meinga lethargy, sleepiness nui, pāhoahoa tamau me te whanoke inati, disorders vestibular.

Mai i kia whakawhanake i te taha o te pūnaha hematopoiesis me pūnaha Cardiovascular eosinophilia, thrombocytopenia, me pancytopenia, anemia syndrome, tachycardia, pēhanga toto mā'olunga, te whanaketanga o te hyperkalemia.

Ko te whakamahi o "Nimesulide" me arotake

Mā te whakamahi i te "Nimesulide" tangohia mau tona wahi i roto i te haumanu mate rheumatologic o te pūnaha musculoskeletal. Ahakoa te whāititanga nui i roto i te iteraa papu ki te tarukino "nimesulide" urupare pai e pā ana ki taua mea e tika ana ki tona kakama tiketike i roto i te maimoatanga o mate rūmātiki. Ko e tika ana ki te pū o ngā pānga i runga i cyclooxygenase-2 me te nui rawa o te selectivity mo tenei whākōkī tenei.

Ara

He aha Me kia tupato, ka tango i tenei tarukino rite "Nimesulide"? Tohutohu mō te whakamahi, i ngā arotake manawanui e pā ana ki te tahi mau faaararaa. He wāhi nui i roto i te ūnga "nimesulide" takanga ko te whakamahi o te iti horopeta whakaora o te tarukino. I roto i te ngaro o te miramira ki dosing iti fariiraa i te tarukino kia mutu.

I roto i te take o hepatotoxicity o te tarukino (aroturuki nei e mataora toto) te fariiraa i te tarukino me mutu hoki tonu. Tenei rōpū o tūroro (e whakawhanake ate whara pūtau) rāhuitia taumahi atu "Nimesulide." Me kï reira e ara i roto i te ngaro o ngā pānga taha ate tarukino kore kia ngā ki taero hepatotoxic, atu NSAIDs, Pë. Hoki, kia pehi i inu waipiro.

"Nimesulide" kia waiho te nui rawa o te tūpato homai ki tūroro he ate iti hoki tākihi ranei ki te karo i te tūpono o ahunga whakamua o te muri.

kia utua ngā whakarongo ki te whakarite o te tarukino ki te tūroro ki ngā tohu rewharewha-rite. Ko e tika ana ki te meka e "nimesulide" roaa pānga antipyretic me he taea ki te huna kanohi i te tohu o te whakapokenga huakita tenei.

taunekeneke Drug

Nā ki te kaha teitei o te tarukino ki meinga toto intestinal "Nimesulide" e kore e kia ngā ki anticoagulants pērā i "fafati" rite reira he he tūpono nui o ngā pānga taha.

Ko te kaha o te tarukino whakapōrearea i te mahi o te cytochrome P450. I roto i te tirohanga o te mahi mahi o inhibition o te inenga paru o taero metabolized e te tikanga o te cytochrome Me hou whakararo.

"Nimesulide": analogues, arotake

Ko te analogs matua (hei māngai kaha) e "Nimid", "Nimesil", "Remesulid", "puru-sanovel". He wātea te tarukino i roto i te papa puka 100 sachets mg ranei i te puka o te rā ki te 10 mg (ia 1 go o rā). He pai mahi haumanu o analogues o te raau taero, na mahue tūroro e pā ana ki o ratou arotake rite pai. Tūroro ka mahue i te "Nimesulide" tikanga arotake, hei papa iti atu i te raau taero i roto i te puka o te paihere.

mutunga

"Nimesulide" Ko te māngai anti-inflammatory puai ki te hamani mate inflammatory, pūnaha rawa musculoskeletal. kia mohio ki te kōrero ki tō tākuta e pā ana ki te tango "Nimesulide" tarukino no o te tūpono tiketike o ngā pānga taha he tika. Reviews rata e tuhituhia te raau taero, me tūroro tango ona pai, mai i whakatairanga reira whakaiti tere o ngā tohu mate.