Tohutohu "Gonal-F." Whakaahuatanga o te faaineineraa, contraindications, analogs me arotake

Ko tētahi o nga tikanga noa o te maimoatanga pākoko ko ki te whakaongaonga kano. Hoki hua maha e tika ana mō te kikiritanga, he mea e tika ana ki te whakahaere i te therapy mua tarukino-motuhake. "Gonal-F" whakaaro te tetahi o nga taero whai hua tino i roto i tenei rohe. Tohutohu "Gonal-F" kaha taunaki maimoatanga i raro i te tirotiro tino hauora.

Whakaahuatanga o

Te tangata e matau e kahore kano hapūtanga kore e taea puta. Na reira, he tokomaha o te sex ataahua, fehangahangai ki te taua raruraru uaua ki te kia faatiti'aifarohia ki whakaongaonga me te i roto i te kikiritanga vitro. Me te rata haere tuatahi kawe i te whakamātautau hauora, tangohia ake te kaupapa hāngai o te tukanga me te taka e tika ana.

hāngai ana te taputapu tino haumaru, me te whai hua e runga ruahuru whakaongaonga taiki - FSH (recombinant), i te haepapa hoki te matuatanga o follicles i roto i nga wahine. Tohutohu "Gonal-F" pūrongo e no te tarukino ki tenei kāwai, me he rite tata ki te FSH tūturu te huarahi o te mahi. Hokona rongoā anake i runga i whakahaunga o tākuta.

Tuhinga

whakaritea tono Drug i roto i te mara gynecological me te ka ki te whakahohe i te tupu o follicles. Tuhinga mō te whakamahi "Gonal-F" kua te whai ake:

• Ngaro o te kano me te hua kore pai i muri i te tono "Clomiphene".
• syndrome ovarian polycystic (māuiuitanga e pā ana ki disorders hormonal meinga arā o nga ovaries).
• Ko te hiahia mo te whakaongaonga o follicles maha mō te IVF.

Kua whakapumautia rangahau maha hauora te miramira o te tarukino, i te whanaketanga e tika ana o follicles maha i roto i te tukanga o te hyperstimulation ovarian (whakahaeretia). I whakapumautia te reira e whakatairanga te whakauru mātātoa te tupu o follicles, a ko te kupu tino whakaiti i te mōrea o te hyperstimulation ovarian.

Taupānga mō te tangata

A, no te hanganga ture-kore ki te mahi taketake o te gonads tane o te tukanga spermatogenesis - te hanganga, me te whanaketanga o te parāoa - he whati. Ruahuru whakaongaonga taiaki tika mo te "tīmata" o tenei tukanga, e pumau 75 ra. Rapu āhua pathological he taea i muri i anake te wahi o tātaritanga rata me te tuku purapura moenga o.

Whakaongaonga (whakahokia ranei) te hanganga noa o ngā tohuhema tane ētahi wā e roa atu i te tukanga rite i roto i nga wahine. Hoki te hua pai o te maimoatanga kia ū tino ki te andrologist tūtohutanga. Me piri koe ki te kai i āta hangaia, e hoatu ake te whakamahi o te waipiro me te nikotīni. Ko reira whakahauanga ki te whakarite taka motuhake. Tohutohu "Gonal-F" tohu e taea te whakamahi i te tarukino ki te whakarei ake i spermatogenesis i roto i nga tangata e whai hypogonadism congenital riro ranei. kia Therapy i raro i te tirotiro tamau o te mātanga e whai wheako i roto i te maimoatanga o te pākoko.

te raau taero

wāhanga Active o te tarukino mahi follitropin Alfa - he taonga e whakaihiihi ana te tupu o follicles i roto i nga wahine ki te raruraru i roto i te pūnaha hypothalamic-rapae o. Ko te bioavailability o te tarukino, i te whakahaere subcutaneously i pā ana ki 70%.

tīmata whakauru Hohe ki te whakaemi i roto i te rauropi i muri i whakahaere toutou. I roto i te 3 ra tuatahi kitea ake i takitoru e te kukū taurite o follitropin Alfa, e tīmata tukanga whakaongaonga.

wāhanga Ngaahi Houalotú roto i te raau taero o te konutai waihā me te hauwai Phosphate dihydrate, waikawa phosphoric, methionine, sucrose, polysorbate 20.

Puka tuku

"Gonal F" hua he kamupene ho'oraa Italian "Ahumahi Farmasyutika Serono SpA". māngai tuku Puka - otinga mō te werohia subcutaneous me lyophilisates mo te wai.

Ko te pāhorehore i roto i te puka o ngā pene e taea i roto i 0.5, 0.75 me te 1.5 ml. Ko te horopeta raro e ōrite ana ki te 22 micrograms o follitropin Alfa (300 Iu), reo - 33 mg o whakauru kaha (450 Iu). Ko te nui nui rawa o te kaihoko kaha i roto i roto i te 1.5 ml - 66 micrograms ( "Gonal-F 900"). Ko te utu o te raau taero tei runga i te kukū o te taonga kaha.

He pene te dispenser motuhake, me te tauine, e āhei koe ki te whakahaere i te horopeta. I roto i tenei puka o rongoā te hoko i te whakawhetai tino pai ki ngā toketaá ki. kia pēnei te painga, me kahore he take mo te faaineineraa o te otinga ki te aroaro o ia werohanga.

diluted Lyophilizate mō te faaineineraa o te otinga mō te werohia e ki te wai i mua i ia whawhe. Ko te inenga e hiahiatia ana o te mua-Tātaitia te mātanga mō te take ia takitahi.

Kia pehea te ko te maimoatanga o "Gonalom-F"?

I roto i te ngaro o te kano haamata therapy i roto i te wiki tuatahi o te huringa paheketanga, ngā waipara auau (taea etahi ine auau). kia te tukanga o te whakaongaonga kia whakatinana i raro i te mana o te ultrasound ako, e taea ai e koe te whakahaere i te rahi o te follicles. Tīmata horopeta - 0,13-0,25 ml tarukino "Gonal-F 75". otinga Utu kei 5.5 mg o follitropin Alfa, ko te raro me ko a tawhio noa 110 moni. Whakanuia te horopeta i runga i 1-2 wiki ki 225 Iu (mōrahi).

Ki te i roto i te marama kotahi e kore e hoatu e hua pai maimoatanga, kia mutu therapy tarukino. Ka kia nui haere inenga tuatahi mō te maimoatanga atu.

A, no te whakahaere te hiahia hoki te mana tarukino hyperstimulation ovarian te i roto i te inenga o te 150-225 Iu. E kore e te horopeta rā mōrahi nui 450 Iu. haamata Therapy ki 2-3 ra o te huringa te paheketanga. Ki te awhina o ultrasound mātanga ka aroturuki i te tupu o follicles. pea te roanga o te maimoatanga i 5 ki te 20 nga ra. I muri i te whaowhia whakamutunga, 48 haora i muri, he werohanga o gonadotropin chorionic tangata.

Tangata e whai raruraru ki te tukanga spermotogenez whakaatu hoki whakaongaonga. "Gonal-F" i roto i tenei take e whakamahia ana i roto i ngā ki gonadotropin chorionic tangata. Mua talena maimoatanga ko te werohanga subcutaneous o te tarukino e toru ngā wā i te wiki (horopeta 150 Iu). kia i te iti rawa 4 marama, i muri i nei hiahia te tangata ki te kia te uiui e te roa o te therapy. Ki te iti ranei kahore whakapai ake i roto i nga hua o te maimoatanga kia whakawhānui ki te 18 marama.

dosing

kia te werohanga tuatahi o te tarukino te mātanga i roto i te fare ma'i. Ka whakaakona, i roto i te heke mai ka taea e te manawanui whakamahi i te pene me te hanga i te pere, "Gonal-F." tuatahi me maheni ki te tohutohu ki te tarukino.

Ko te tūtohutanga e whai ake nei mo te whakamahi motuhake o te tarukino:

1. I mua i te wero, "Gonal-F", kia horoi o ratou ringa tino ki te hopi me te wai, me te pea atu tukatuka rongoā.
2. Decomposed i runga i te mata ma tūemi hiahiatia: pene pūwero, oko o te paura, me te wai mo te werohia, swabs waipiro.
3. He mea tika ki te faaineine i te pene, tango te potae, whakaturia te inenga e hiahiatia ana, ka tāpiri i te ngira.
4. Lyophilisate (paura) diluted ki te wai mō te werohanga i te whakauru wai ki te pounamu ki te taonga maroke. Me kia te uhi rapa ngira poka ki te whakatuwhera i te pounamu e kore te mea e tika. kia whakaurua te wai āta.
5. Ko reira ki te waea ki te pūwero rangi tae noa ki te horopeta hiahiatia, te whakauru i te ngira ki te pounamu ki te otinga o (tahuri mua huripokitia e), ki te whakauru rangi, me te waea i te nui e hiahiatia ana o tarukino.
6. kia te pūwero kahore mirumiru hau. I roto i te tikanga ki te pehea o ratou, e hiahia ana koe ki te pato i tō maihao i runga i nga taiepa o te pūwero me neke te mirumiru ki te tihi. Na ka ko reira e tika ana ki te pana i te plunger me ki te tuku hau i te taikaha.
7. kia tukinotia kiri ki te rongoā horoi (waipiro) i te wāhi i werohia.
8. meatia te werohanga te subcutaneously i 45 90 ranei nga nekehanga. Koi ki te pēhi kore he e tika ana te plunger. Me whakahaere te tarukino āta.
9. Hoki whakahaere "Gonal-F" mā ngā pene pūwero he rawaka ki te pēhi i te pātene tīmatanga. Ko te ngira i roto i tenei pūrere he kikokore, me te iti, na te mamae ngawari ranei tata ngaro.
10. I muri i te werohanga ki te pae o te werohia kia haere tahi e te ūkuia miro waiwaitia i roto i rongoā.
11. pūwero tuku mahue i muri i te tukanga.
12. Ki te takoto te tikanga kia nekehia atu kakau ngira-pūwero, hoatu ki runga ki te potae. Ko e tika ana hoki te whawhe i muri ki te whakamahi i te ngira hou, oti nei mai ki te tarukino.

pānga taha

Te faaineineraa "Gonal-F" kia meinga pānga taha i roto i te maimoatanga. tuhia ētahi wahine te tohu e whai ake nei:

• pūnaha whakaputa uri - maha whakawhanake cysts ovarian.
• Ko te pānga kino o te tarukino e taea pā i te whekau o te wahi kūnatu. Kei te whakahuatia te reira i roto i te ahua o te whakapairuaki, ruaki, korere, hūhi me te mamae i roto i te puku.
• kia puta te wāhi i werohia huamo whero o te kiri ranei.
• He tino onge take o mate pāwera: hikaka, minamina, uaua manawa, ohorere.
• I runga i te wahi o te pūnaha io pokapū - kia riro pāhoahoa atu auau.
• Te iti rawa maha i reira he take o te pā tōraro i runga i te pūnaha Cardiovascular (thromboembolism).

Tohutohu "Gonal-F" tohu e kia kitea nga tangata ki te maimoatanga hakihaki, paku nui haere taimaha tinana. He take onge o varicocele, gynecomastia.

contraindications

Te raau e te kaha pānga i runga i te tinana, me te reira e kore e taea te whakahaere, kahore maimoatanga mua. Ko te taonga kaha me ngā wāhanga atu i te tahi mau fakangatangata ka whakamahia. kia tango i te rata tenei ki pūkete, me te whakatika i te talena maimoatanga.

Tohutohu "Gonal-F" faaara e rāhuitia te tarukino te ki te whakamahi hoki te iwi ki te ātete kai hypersensitivity ranei ki matū i roto i te waihanga. I roto i tenei take, kia whakawhanake i nui te tauhohenga pāwera atu pōauautanga ranei. Hoki Contraindications ngā:

• Uterine toto o te etiology unknown.
• māuiuitanga Oncologic o kikokiko ā-.
• cysts ovarian katea e kua whakawhanakehia i roto i te papamuri o te polycystic.
• Pregnancy me te hohipera.
• abnormalities congenital o whēkau, i he tütukitanga taua hunga ki te hapū.

e te tohunga ki pūkete nga comorbidities katoa e te hunga e wātea ana i roto i te aamu o te manawanui. I roto i te tahi mau āhuatanga, kahore he hiahia ki te whakamahi i ngā taputapu, "Gonal-F." Utu o te maimoatanga tei runga i te roanga o te maimoatanga me te inenga o te raau taero, engari ara maimoatanga utu kore kawea te hua e tūmanakohia ana i roto i taua pathologies rite fibroids uterine, menopause taimi halá, arai o te korere kākano.

Āhuatanga o te tono

I mua i te tautapa koe he tarukino ki te whakaongaonga kano ranei tukanga spermatogenesis, he tākuta motuhake i roto i te maimoatanga o te pākoko, kia whakahaere faaipoipo tātaritanga hauora, ki te āwhina i whakahaere tikanga i roto i te aroaro o contraindications me te hiahia mō te maimoatanga. Ko hoki reira e tika ana, a ka te kaupapa inenga kia tāuta.

Tūroro e mamae whakaongaonga "Gonalom-F" i mua i faarahi IVF te tūponotanga o whiwhi hapu ki mahanga. takoto ana te tākuta kei te ki whakamōhio te wahine ki te aroaro o te tīmatanga o te maimoatanga.

whakamahi tukutahi o te tarukino me te tahi atu āpiha e whakaawe te tupu o follicles, taea whakapataritari whanaketanga o hyperstimulation. I roto i te akoranga o te therapy he tika ki te whakahaere tātaritanga ultrasonic, me te aroturuki i te tupu o follicles.

"Gonal-F": te utu, me arotake

He kē tarukino Italian ki te whakaongaonga kano mo te wa roa i whakaritea mo te maimoatanga o te pākoko i roto i rua tangata me nga wahine. Tenei Ko tetahi o nga taputapu whai hua tino (maha tākuta kōrero ki reira rite "puhipuhi taimaha"). whakakitea "Gonal-F" hua pai noa i roto i te wā i reira i kaha atu tikanga mohio. Ko te tikanga taketake ki te kia aru e tūroro, kei roto i te mana hauora ki tonu te tukanga o hoholo follicles me spermatogenesis.

I roto i te inenga maimoatanga kia puta ke ai i roto i te iti me te i roto i te ara nui. Ko te utu o te tarukino rerekē i te 1100 moni. ki runga ki te 16 000 moni. ( "Gonal-F" 900 Iu). I tua atu ki te whakamahi o taputapu utu, he mea nui ki te whai i etahi ture i roto i te kai, me te tino faaore kai paraurehe, hua āhua-oti.

I roto i therapy, riria mai ki te inu waipiro, e kua he pānga tōraro i runga i parāoa production, e pa ana i te repe, me te hypothalamus, ia mutu te pākia o steroids sex. tūtohutanga Nui ake i roto i te parāoa me te nikotīni.