Treatment "sofosbuvir": arotake. "Sofosbuvir" + "Daklatasvir": arotake tohunga. "Sofosbuvir": te ako o tākuta arotake

Ko te ate ko te ahua o te tātari purenga mo te tinana tangata. Herenga o te tinana pānga te mahi o ngā pūnaha maha, me te kounga o te ora te tangata i roto i te whānui. Ko tētahi o te ate tino nui whakaaro te ki hei kakā C. I te wa hakari ki te mahi ki te mate whakawhanakehia he rota o raau taero. Ko tētahi o nga taputapu whai hua tino te whakaaro (whakapumautia nei e te arotake hauora) "sofosbuvir".

Tuhinga mō te whakamahi

Ko te tikanga sofosbuvir huaina reira whakauru kaha i roto i te papa, me te waitohu ano kua te ingoa hokohoko "Sovaldi". Ko te kupu, ko reira taea ki te mea e tenei rongoā iti whakakapi - kano "sofosbuvir" e arotake whakaahua i te tarukino rite tetahi o nga taero whai hua tino mo te maimoatanga o te kakā ko tona wāhi matua o te tono tenei C..

rauemi Base - sofosbuvir - ko te inhibitor o te NS5B polymerase viral, arā, inhibits tukanga tukuruatanga viral - .. te kaihoko fakatupu o kakā C. Heoi, te nuinga o ngā tohunga hauora e kore tūtohu monotherapy "sofosbuvir" (ahakoa he reira i roto i te parau tumu taea). Engari kia rite ki te wähanga kaha matua o te therapy matatini o te tarukino huaketo "sofosbuvir" whakautu te mea he anake te aronga pai, characterizing reira rite te tikanga tino whai hua. E ai ki nga rangahau haumanu whakahaere, ko te tarukino i roto i te taupiri whakakitea ki ētahi atu taero hua pai i roto i te maimoatanga o te kakā C (tohuira 1, 2, 3).

Treatment "sofosbuvir" kaimahi hauora he urupare pai e kore anake hoki ratou tūroro kore tukinotia, engari ano mo te hunga e kua riro therapy mua ki ētahi atu taero patu huaketo, me i te mutunga o te maimoatanga i muri i te wa ki te tiki i te matahoki.

Haunga te rohe i runga ake-whakaahuatia o mana, "sofosbuvir 'arotake me tūtohutanga o kaiwhakaako tohutohu tukua te whakamahi i roto i te maimoatanga o te tūroro mate ana i cirrhosis o te ate.

No nia i te whai huatanga o te tarukino ki HIV me kakā tahi-mate (he āhuatanga tika noa), ko tēnei wā tenei mōhiohio e kore e wātea ana, ahakoa tohua te tarukino te mo te whakamahi i roto i taua mau huru ohipa.

contraindications

I roto i te nuinga o te wā, te tarukino iho me ona taero kano te pai noatia e tūroro.

Heoi medicament mo te maimoatanga o te kakā C "Sovaldi" (ranei "sofosbuvir") whakautu e he aronga pai, kia rite ki tetahi hou medicament tino pai, he contraindications hoki etahi tono.

Tuatahi, tenei hypersensitivity takitahi ki te medicament matua me ngā wāhanga pŭpŭ tauturu. Me kia koe tupato ka whakamahi i te reira wahine nei e o te whanautanga tamariki tau. I roto i ngā, ki te "Sovaldi" ( "sofosbuvir") whakaritea te roto i te taha ki "Ribavirin" me "interferon-Arepa" (tohuira tūturu mō te 3, 4, 5, 6, kakā) kia karohia i roto i ngā ara hapū. Ko te tino e minaminatia ki te hamani enei māngai i roto i te hapū, me te hohipera hoki reira.

I tēnei wā, he wātea te mana o te "sofosbuvir" mōhiohio tangata uri. Kahore he hoki kahore kōrero i runga i te haumaru me te aonga o te tarukino i roto i te tūroro i raro i te 18 tau o te tau.

Inenga me te roanga o te akoranga therapy

I te tīmatanga e stipulate e therapy huaketo he manakohia ki te kawe i roto i anake aua ngaio hauora e whai rawaka wheako i roto i te rongoā tūroro ki kakā C. Ko te talena paerewa - 1 papa (400 mg o taonga kaha) i roto i te ra i roto i tetahi wā kai. Ka rite ki te pire kawa (pērā i tango arotake rongoā) "sofosbuvir" kia horomia kahore ngaungau whawhati he ranei.

Ki te mea kua kua tangohia te papa, a muri i roto i te 2 haora i muri Tīmata ruaki, e tūtohu ana ki te tango i tetahi kotahi papa. I roto i te take o te ruaki mo te wā o te wā, kua haere, neke atu i te 2 haora, e tangohia e kore te mea e tika ana te horopeta atu.

Ki te tahuri te horopeta i muri mo etahi take i roto i ki te tīpoka (te wā o te roa e kore e nui atu 18 haora), e tūtohu ana ki te tango i te horopeta ngaro a ka te wa noa ki te haere tonu maimoatanga. Ki te nui ake te roa 18 haora - tango i te horopeta i muri i te wa mua.

whakaora pahekotanga

Ka rite ki wāhanga prolechivanii adjuvant therapy i kakā C, me te "sofosbuvir" mahi taumahi "ribavirin", "interferon alpha", "Daklatasvira", "Ledipasvira", "Asunaprevira".

Ko te tikanga, ko te taupiri "sofosbuvir" + "Daklatasvir" arotake kaimahi tiaki hauora me tūroro āhuatanga rite whai hua ki ngā tohuira kakā C 1,2,3.

Ki te rā, "Daklatasvir" taea te tono ipurangi WWW.ARV24.COM tukua ki o koutou ringa - i roto i te kamupene ki te ingoa roa-tu. Engari e reira kei runga i te ringa te kōrero e tika ana katoa e pā ana ki te aroaro o te mate.

Tohuira 4, 5, 6 te tukinotia medicaments matatini "sofosbuvir", "ribavirin" me "Arepa Interferon". wā whakaora Paerewa ko i te iti rawa 12 wiki. I roto i te wā i reira tūroro ki ngā tohuira 1, 4, 5, 6 whai contraindications mō te fariiraa i "Interferon alpha" e whakatakotoria hypersensitivity ki te taonga, "sofosbuvir" ki "Ribavirin" whakaritea te ki te farii i 24 wiki ranei.

Taupiri "Ribavirin" ki "sofosbuvir" tarukino mō te tohuira 2 arotake tohunga whakaahua hoki pehea ki optimally whai hua huinga whakaritea e te ki te riro hoki te wā o te kore iti iho i te 12 wiki. Enei medicament rua, engari mo te wā o te iti rawa 24 wiki, ka tono reira 3 tohuira o kakā C.

e kore te mea e wātea ana ngā mōhiohio e pā ana ki te whai huatanga o te ngā therapy ki "Ribavirin" me "interferon" mo te maimoatanga o te tohuira 1.

I roto i taua take, ki te te te mamae i te manawanui i hepatocarcinoma tatari pokanga mo te transplant ate, me / ranei, te mahi o te whakatū "sofosbuvir" i roto i ngā ki "Ribavirin" mo 48 wiki noa te rā o te pokanga mo te transplant okana ranei. He nui i roto i te tikanga ki te ārai i te mate o te ate i muri i transplantation tenei.

rangahau Haumanu fokotu'u e te fariiraa "sofosbuvir" ngā ki ētahi atu taero whakarato te whakautu eu pai virological i 92% o ngā take o te adjuvant therapy i te maimoatanga o te kakā C.

pānga taha pea

I roto i te akoranga o te mau tamataraa haumanu te tino pai noatia te raau e tūroro (pera i o ratou whakawākanga). "Sofosbuvir" ai ngā kino i roto i nuinga o te wā ka whakamahia i roto i ngā ki "Ribavirin" me "interferon".

A, no te ngā "sofosbuvir" ki "Ribavirin" maha nui (neke atu i te 10% o te wā) i roto i te pūtoto kukū, ka nui haere bilirubin kia faaiteraa o te rohirohi heke toto hanganga, kārangirangi me te ohoroa, whakapairuaki.

Iti noa (iti iho i te 10% o ngā take), tenei huinga o taero whakaoho korekore, anemia, nasopharyngitis, kukū waimaero, dyspepsia, kōroke me disorders intestinal, tauhohe mate pāwera i runga i te kiri (patito, ohorere). I te tahi taime e mahue tūroro, me enei whakawākanga "sofosbuvir" whakamahia i roto i te whakarara ki "Ribavirin" ko te take o te mate makawe me te mamae hoki, cramps, myalgia, me asthenia.

Ki te whakamahi koe i te matatini o e toru ngā rongoā (e rua te ingoa i runga tāpiri "interferon alpha"), rawa maha (neke atu i te 10% o te wā) i reira ko te rārangi nui whānui o ngā kino. Tenei e korero tatou e pā ana ki ngā rerekētanga i roto i te toto: ko te whakaiti i te reira i te maha o lymphocytes, neutrophils me platelets, anemia, taumata bilirubin faateiteihia. I runga i te wahi o te wahi kūnatu kia whakawhanake korere, whakapairuaki, ruaki. I tua atu, "sofosbuvir" (ture, mua manawanui me ngaio hauora tautoko) e taea meinga pāhoahoa, whanoke, mare, wheezing, minamina me te hikaka, myalgia me te mamae tahi. pinepine kōrero Tūroro e pā ana ki te rohirohi, irritability, ruaki, nui haere te pāmahana tinana.

Iti noa (1 ki te 10%) tūroro mea e pā ana ki te wehi, me te whanaketanga o te korekore, ki te whakaiti i taimaha tinana, e pā ana ki te mahara me te kukū ine o migraines. He he mōhiohio e pā ana ki te ino o te whakakitenga, makawe mate, te whanaketanga o te Reflux me torutoru o ka te piki kawenga manawa. I te tahi taime e mea tūroro e pā ana ki te mamae i roto i te hoki me te pouaka, cramps me te rohirohi.

He aha e hiahia ana koe ki te mohio?

Ki te he tetahi ranei atu kino āhuatanga te manawanui - tiketike tuatahi kawenga viral, kakakīrehe i roto i te wā arā atu anō, kiri pouri rawa - te maimoatanga o "sofosbuvir" (arotake o tohunga me tohutohu pehea ki te whakamahi i te tautoko) kia nui haere e ki runga ki te 24 wiki. A, no te whakahaere tīpakohia te therapy ngā whai hua horopeta "ribavirin" kei te rite ki te taimaha tinana o te manawanui, ie. Rapu E. 75 kg tinana taimaha 1.2 go o medicament. Kei te wehea te nui katoa o te tarukino ki e rua nga wahi, ka tangohia ki te kai.

Whakaititia te inenga "sofosbuvir" e kore e tūtohu.

Ki te he tono tahi "Solfosbuvira" me "Arepa interferon" whakawhanake faaiteraa kino āhuatanga o te raau taero muri, riro he horopeta o "Interferon" e hiahiatia ki te whakaiti ranei ara mutu tango tenei rongoā (ture taipitopito i runga i whakaiti o horopeta withdrawal o te tarukino ranei, i reira he tohutohu motuhake).

I roto i rite te mahi taua ka reira te mea he huinga "sofosbuvir" ki "Ribavirin", ka whakawhanake i te pānga kino i runga i te fariiraa o te whakamutunga - heke horopeta ranei mutu rawa mai, "Ribavirin". I muri whakapai ake i te hua o te whakamātautau toto, he reira manakohia ki te tamata ki anō fariiraa i "ribavirin", timata mai i 600 mg me āta mau mai ki 800 mg. E kore e tūtohu ana ki te whakapiki ake i te horopeta ki te ūnga taketake.

Ki te whakakore koe tetahi o te rongoā ngā therapy he tika ki te tino mutu tango "sofosbuvir" - kōrero i te tohunga, me ngā tohutohu mō te whakamahi i ngā tohutohu ko te taua i roto i tenei whakaaro.

Ngā pāhekoheko ki ētahi atu matū

e kore e tūtohutia kaimahi hauora mō ngā tūroro i roto i whakarara ki te tarukino whakaaro ki te whakamahi i ētahi atu taero patu huaketo (anake mo te rata te rongoā) i roto i te wā, ka kawea maimoatanga te kakā. whakaaro "Sofosbuvir" arotake tohunga reira taea ki te ngā i te tahi mea atu anake i roto i te wā i reira te painga tūmanakohia i te huinga o te raau taero atu te tūpono o ngā pānga kōaro.

He hoki he rōpū o taero, te whakamahi tahi ki "sofosbuvir" taea nui whakaiti tona absorption ( "sofosbuvir") i roto i te piro. Enei taero - o anticonvulsants - ngā "Phenytoin", "Phenobarbital", "carbamazepine" me "Oxcarbazepine." rongoā rōpū Antimycobacterial ngā ano taua tikanga "Rifabutin", "Rifampicin", "Rifapentine". Mai i tāpiringa otaota tino raro absorbability "sofosbuvir" kia Hypericum. Hoki e kore tūtohu ki ngā rongoā ki inhibitors protease HIV, "Tipranavir", "Ritonavir".

tohutohu motuhake

mo te tākuta anake whakau ana te whiriwhiri tika o te maimoatanga talena mo kakā C, me taero e kua whakaritea mō "Ledipasvir", "Asunaprevir", "sofosbuvir", "Daklatasvir". Urupare i tūroro e pai arowhānui katoa "Sovaldi".

Heoi, kia whanau ai i roto i te ngakau e, hoki tūroro ki nui täkihi, kia tīpakohia te rōrahi horopeta āta. Kahore he hiahia ki te tatau anō i te inenga o te hunga e mamae i ngawari ki te mate āhua. Ki te whakaaro ki te kore ate, kahore he hiahia ki te whakatika i te horopeta mō ngā tūroro ki tetahi tohu o te pakeke o te mate.

I roto i te maimoatanga o te kakā C ki te whakamahi i runga i te pūtake o kore te tūtohu "sofosbuvir" huinga therapy ki te whai wāhi i roto i te hunga mahi e rapua e kukū tiketike, me te tere o te tauhohe whakamātau tinana.

awhe utu

Ko te utu o te tarukino tahu i roto i te Germany he i waenganui i 18 ki te 20 mano euros. A ki te hoko i te reira noa i tenei utu ka hiahia te whakahaunga i te taote e haere ana. he uara nui pērā o te moni e tika ana ki te meka e kua te kamupene-kaiwhakawhanake ki te whakarite ona utu katoa mo te rangahau, te whanaketanga me te whakamātautau o te tarukino.

utu ngawari ki nga rongoa kiritaki, whānui (analogues iti waitohu ki te taonga kaha tino ōrite). Ko reira ki taua āwangawanga "Daklatasvir", "Asunaprevir", "Ledipasvir" me "sofosbuvir". Kei roto arotake Kiritaki mōhiohio e pā ana ki te utu nui o enei taero, Heoi, e kore e tatou korero e pā ana ki o mano tekau o euros.

Tīmata i Maehe 2015, i rite ki nga raihana kamupene-kaiwhakawhanake, timata take o "sofosbuvir" ope Natko te kamupene ho'oraa Indian (o te akoranga, me te whakaaetanga o te Manatū o Hauora o India).

I tēnei wā, he mau Russia roto ki toa ipurangi hoko i te mōkihi (28 papa) tarukino "sofosbuvir" mo 39 900 moni (ka utu 1 papa te kiritaki i roto i te nui o e pā ana ki 1800 moni). Ehara i te cheap, engari rite ka rapua e te taua tākai parani "Sovaldi" haumi i roto i te nui o 1.5 miriona moni, i te mea tata 35 ngā wā atu te utu atu i te utu o tetahi kano.

Na roto i mekameka rongoā tae noa e kore e taea e koe te hoko i tenei tarukino, t. Ki. Ko te tukanga tohu mō taero hou i roto i Russia kaua roa.

Ko te whakaaro o kiritaki me rata

ka mau te medicament tūroro ki ngā tohuira rerekē o kakā, Fibrosis rerekē ngā taumata ki kuputohu o transaminase me tino runga ake te täkupu, te tikanga he kawenga viral tiketike.

Ko te nuinga rawa o te tūroro e tangohia e te rongoā, mahue urupare pai e pā ana ki te "sofosbuvir" tikanga. Ko wai i tukinotia (maha i roto i arotake taua mōhiohio) i mua kakā C interferons fokotu'u e kore e taea e taero noa whakataurite. meinga Interferons te rota o ngā pānga taha, a kahore tūroro katoa i te kaha ki te kawe ia ratou. Ko te huinga o "sofosbuvir" me "Daklatasvir" (tino maha tūroro mea e pā ana ki te taupiri taua), anake te ōrau iti o tukinotia ki enei āpiha korero e pā ana ki te whanaketanga o ngā pānga iti kino rite whanoke, pāhoahoa, e kore kaha, me te mate o te ruruku wā-poto. Heoi, e kore e enei tohu haere ki tetahi rite ki te pānga taha o te "interferon" me nga mau hopearaa o te kakā. I te mutunga o 2-3 wiki o therapy i roto i tūroro maha, whiwhi hoki ki te ihirangi noa i roto i te transaminases ate. Tīmata i te toru o wiki o te maimoatanga antivirals matatini "sofosbuvir" me "Daklatasvir" i roto i te maha tūroro mo te aroaro i roto i te tinana o te kakā huaketo C tōraro.

Ano, pūrongo maha tūroro he whakaiti nui o kakakīrehe i roto i te marama torutoru, te whakamahi o te huinga therapy.

Ko te hunga kiritaki e kua tangohia te matatini o toru rongoā - "sofosbuvir", "Daklatasvir", "Ribaverin" - he tino pai ki te hua o te maimoatanga hoki i.

Tata ki te katoa kiritaki "sofosbuvir" korero e pā ana ki te pakaruhanga tūturu i roto i te maimoatanga o te kakā C i roto i te rite ki te interferonotherapy. Tino whakapai ake i te hauora me te kounga o te ora - ki te tohu tika.