Desensitizing āpiha: he rārangi me te whakamārama

Desensitizing āpiha (antiallergics, antihistamines) - taero e kua whakamahia i roto i te maimoatanga o tikanga mate pāwera. whakaaturia te tikanga o te mahi o taua tikanga i roto i te puka o ārai nga receptors H1-histamine. Na reira, he pehanga o pānga histamine - te taonga takawaenga matua e whakarato ana te nuinga o te ahua o tohu mate pāwera.

Histamine tāutuhia i te kopa kararehe i roto i 1907, i 1936, ka ki, kitea te raau taero tuatahi i nei leva te pānga o tenei taonga. rangahau maha whakaaro e he reira i roto i tona pānga i runga i gistaminoretseptory matehā pūnaha, kiri me kanohi ai i nga tohu angamaheni o mate pāwera, me antihistamines taea pehi tenei tauhohenga.

Whakarōpū o āpiha desensitizing i runga i te huarahi o ngā pānga i runga i ngā momo rerekē o mate pāwera:

• Medications mō te momo tonu tauhohe mate pāwera.

• Medications hoki roa-momo hypersensitivity.

Rongoā mō te momo tonu tauhohe mate pāwera

1. Agents e tautāwhi i te tuku o kaitakawaenga mate pāwera i ngā pūtau uaua maeneene me te basophilic, te inhibition kitea o te Niniiraa cytotoxic o tauhohenga pāwera :

• moni β1-Adrenomimeticalkie;

• glucocorticoid;

• myotropic pānga antispasmodic.

2. stabilizers kiriuhi pūtau.

3. blockers pūtau receptor H1-histamine.

4. Desensitizing.

5. Ko nga inhibitors o te pūnaha ngä.

Agents mahi i runga i te roa-momo hypersensitivity

1. NSAIDs.

2. Glucocorticoid.

3. cytotoxic.

pathogenesis o mate pāwera

Ko te whanaketanga pathogenetic o mate pāwera nui synthesized he wāhi nui o te histamine te i histidine me te takoto i roto i basophils (pūtau rewa), te kiko tūhonohono (tae atu toto) platelets, eosinophils, lymphocytes, me fluids koiora. Histamine i roto i te pūtau kanohi wāhanga deaktivnoy ngā ki pūmua me polysaccharides. Kei te tukua te reira e tika ana ki te pūtau koha aunoa, tauhohe ārai, i raro i te mana o ngā hua matū me pharmaceuticals. puta Inactivation mā tona histaminase o kiko mucosal. Whakaoho H1 mau farii ohipa i ngā reira phospholipids membrane. Nā ki te tauhohe matū, te tikanga e whai wāhi ki te kătahi ki te Ca pūtau, me nga mahi o muri i runga i hukihuki uaua maeneene.

Mahi histamine H2 gistaminoretseptory arata'i ki kaha cyclase adenylate me piki i roto i te hanga puni pūtau, faatupu te reira i te hua i roto i te secretion o te mucosa pekitīlia. Ko te kupu, Kei te whakamahia etahi māngai desensitizing ki te whakaiti i te secretion o HCl.

Histamine hua toronga capillary whakarato amplification uruhanga o taiepa iaia, whakautu edematous, whakaiti rōrahi wē, e tika ana ki te thickening o whakaiti pēhanga toto i roto i te pera, paparanga maheni uaua hukihuki arahau tika ki ritenga H1 gistaminoretseptorov; whakapakari o tuku Adrenaline, mokowhiti tere.

Acting i runga i nga receptors H1 o taiepa capillary endothelial, tuku histamine prostacyclin, e haamaitai te reira whakawātea o oko iti (rawa venules) Escrow reira toto, maturuturu i roto i komuhumuhu rōrahi toto, tenei whakarite e te tuku o wē, pūmua me ngā pūtau toto i roto i te taiepa roa mezhendotelialnogo wāhi.

Mai te rima tekau o te rau tau 20. a tuku desensitizing mohoa taka huringa hia. Kua whakahaere Scientists ki te waihanga taero hou ki iti pānga taha me te rārangi o atu tōtika. I te wā nei, i reira e toru ngā rōpū matua o taero antiallergic: tuatahi, whakatupuranga tuarua, me te tuatoru.

Desensitizing māngai o te whakatupuranga tuatahi

āpiha Desensitizing whakatupuranga 1 ngāwari haere i roto i te arai toto-roro (BBB) me e hono ki te gistaminoretseptorami uho. whai wāhi ana tēnei desensitizing ki te pānga whakarokiroki, pērā i roto i te puka o te momoe iti, a i roto i te puka o te moe tangi. Medsredstva whakatupuranga 1 ato'a pā tauhohe whakamātau tinana roro. Hoki tenei take, iti ratou whakamahi i roto i ngā rōpū rerekē o tūroro.

Ko hoki He wāhi kino atu mahi whakataetae ki acetylcholine, no te mea e taea e enei taero taunekeneke ki mutunga io muscarinic rite acetylcholine. Na, ki te kahore hoki te mahi reka o enei taero meinga mangai maroke, kōroke, me tachycardia.

Desensitizing whakatupuranga 1 äta whakaritea mo te papahewa, tuwhenua, mate ngakau, a i roto i ngā ki antidiabetic me taero psychotropic. e kore e ratou te tango atu i te kotahi tekau nga ra e tika ki te kaha ki te arahi ki waranga.

Desensitizing āpiha whakatupuranga 2

Ēnei taero i te marena tiketike rawa ki te receptors histamine, me te taonga whiriwhiri, te kupu e kore e mahi i runga i te mau farii ohipa muscarinic. I tua atu, kei te āhuatanga ratou i te kătahi iti puta noa i te BBB me he kahore faatîtîraa, e kore e hua i whakarokiroki (i ētahi wā i roto i te tahi mau tūroro te kaha ki te ngāwari te momoe).

I te mutunga o te fariiraa o te pānga haumanu o taero e taea noho hoki 7 ra.

Ētahi riro pānga anti-inflammatory, pānga cardiotonic. titau te rerekētanga muri mana o te pūnaha Cardiovascular i te wa o to ratou whakauru.

Desensitizing āpiha tuatoru whakatupuranga (hou)

he whakatupuranga hou o taero antisense e āhuatanga e te selectivity tiketike ki gistaminoretseptoram. e kore e ratou meinga whakarokiroki me kihai i pā i te ngakau, me te toto oko.

Whakamahi o enei raau taero i whakamatauria ano i roto i therapy antiallergic auroa - maimoatanga o Rhinitis mate pāwera, rhinoconjunctivitis, urticaria, dermatitis.

Desensitizing taero mō ngā tamariki

rongoā Allergy mō ngā tamariki e no ki te rōpū H1-blockers, ranei raau taero antisense - he tarukino tikanga mo te maimoatanga o ngā tauhohe mate pāwera i roto i te tinana o te tamaiti. I roto i tenei rōpū o ngā rongoā rongonui:

• ahau whakatupuranga.

• II whakatupuranga.

• III whakatupuranga.

Teuteu mo nga tamariki - whakatupuranga ahau

He aha i reira desensitizing taero? Hiki e aroaro ratou i raro:

• "Fenistil" - rekomenovan mō ngā tamariki pakeke atu i marama kotahi i roto i te ahua o pata.

• "Diphenhydramine" - i runga i whitu nga marama.

• "Suprastin" - neke atu i te tau kotahi. I mua i whakaritea e ia anake i roto i te puka injectable me raro anake te tirotiro hauora o te tākuta.

• "Fenkarol" - neke atu i te tau e toru.

• "Diazolin" - i runga i te tau o rua.

• "Clemastine" - i runga i te tau o ono, i muri i te 12 marama. i roto i te puka o te tirikara, me te werohia.

• "Tavegil" - i runga i te tau o ono, i muri i te 12 marama. i roto i te puka o te tirikara, me te werohia.

Teuteu mō ngā tamariki - II Generation

Ko te taero desensitizing tino noa o tenei momo:

• "Zyrtec" - neke atu i te ono marama i roto i te puka o te maturuturunga iho, me te mo ono nga tau i roto i te puka papa.

• "Claritin" - neke atu i te rua tau.

• "Aerius" - neke atu i te kotahi tau i roto i te puka o te tirikara, a mo ma rua nga tau i roto i te puka papa.

Teuteu mō ngā tamariki - III whakatupuranga

Desensitizing māngai o tenei momo ngā:

• "Astemizole" - neke atu i te rua tau.

• "Terfenadine" - neke atu i te toru tau i roto i te puka e iri me neke atu i te ono nga tau i roto i te puka papa.

Te ti'aturi nei tatou e, tēnei tuhinga ko i te kōwhiringa o raau taero anti-mate pāwera hoki te tinana o te tamaiti (me kore anake) ki te āwhina i te whakatere me te hanga i te pai rawa tika. Heoi, kia tuhia te reira e mua ki te whakamahi o taua rongoā kia mohio ki te pānui i te tohutohu, e taea e koe te mahi ki te pātai: "taero desensitization - he aha te mea te reira?". kia rapu ano koe tohutohu hauora.