Peptides poto me polypeptides hei wāhanga o te kai tōtika hākinakina. He aha ki te whiriwhiri?

Peptides Ko te tikanga rongonui whakamahia nei i roto i ngā pūnaha i te faaineineraa o te kai tōtika o kaitäkaro hākinakina i roto i te hākinakina runaruna me ngaio [3]. peptides katoa - hākinakina wāhanga kai tōtika - Ka taea te wehea ki te 2 ngā rōpū: poto (iti) peptides me polypeptides ( "nui"). E tito nga peptides o wāhanga ohie - waikawa amino. Ki te he peptide kei roto i te maha iti o waikawa amino, mo te tauira 3 ranei 4, - ko reira he peptide poto. Ki te te peptide ko 20-30 waikawa amino, me te ake - ko reira he polypeptide. Polypeptides - Ko tata tenei te rite i o pūmua - rāpoi matua i roto i to tatou tinana. Te aha e mea faufaa ki te wehenga ki peptides poto me polypeptides? Mai i te roa o te peptide tei mo tona mahi, te kakama me te haumaru, ka whakamahia i roto i te kai tōtika hākinakina.

I tēnei wā rongonui rite te hākinakina wāhanga kai tōtika he polypeptides e whakatairanga tahunga ngako, whakanui i uaua papatipu, whakanui i te mate, te whakapai ake i te hauora whānui. Heoi, E ratou drawbacks nui. Polypeptides, rawa hormones peptide, kia hotokore ki ia atu, whakapōrearea i te taiaki māori i roto i te tinana. I tua atu, e ke ki te tinana te "nui" peptides katoa a taea meinga mate pāwera. mahi tinana High e tonu whakamatautau te kaipara, whai wāhi maha ki te hekenga i roto i te wātea i te mate, e atu faarahi te taha tauhohe mate pāwera i te whakamahi i te polypeptides. No te mea maha e taratahi te polypeptides i kaiao kararehe [2, 3, 9], takahi horoi hangarau i roto i a ratou poke kino kia hakari - pūmua ke, DNA whatiwhatinga, wheori, prions, e riro ano immunogenicity (kaha ki te kaha ai pāwera) a taea arahi ki te whanaketanga mate.

He mea taea ki te rave i te reira, ki te pupuri i ngā āhuatanga whai hua o polypeptides bioregulatory me i te wa taua ki te tango i to ratou mau paruparu? Ae, inaianei kua riro te reira taea. Ka rite ki te hua o nga tau o te rangahau, i kitea ai e ia polypeptide ko te pokapū hohe - e te wahi iti o te reira, e te mea haepapa mo te mahi o te peptide. I runga anō i te tātaritanga o te hanganga o polypeptides rite ki te hangarau motuhake kua hanga Ideal Pharma GmbH peptides poto, arā, o te 2, 3 ranei 4 toenga waikawa amino [5, 6, 7]. Taua peptides poto kore e tika ki te tutakina i te kopa kararehe, a taea te synthesized ratou matū. Ko reira haumaru hoki e kore e peptides waihanga i roto i kai e meinga mate pāwera. Ko te kupu peptides poto IPH i runga i te hanganga rawa ōrite ki tūturu hohe (mahi) polypeptide rāpoi pokapū, me te kore e mohio a e te tinana kia rite ki matū ke. He mea nui ki te mōhio e peptides poto IPH, te tino "mahi" o te rāpoi ngota polypeptide whakamahia i roto i te kai tōtika hākinakina i ngā taumata o raro atu i te "peptides nui."

Ko tētahi atu painga nui o IPH peptides poto ko te ratou kaha pai riro e te tinana whakaritea ki te polypeptides. Kia pehea te e tupu tenei? Pūmua me polypeptides tomo i te tinana ki te kai, tomo te puku, me te whēkau. He ratou ki te awhina o whākōkī motuhake (peptidases) "tapahia" ki nga whatiwhatinga iti - peptides poto arā, o 2 ranei 3 ngā toenga waikawa amino. Na ka tomo peptides poto te toto, ka kawea ki te uaua, me te tahi atu okana me te kopa, e whai he pānga ture. Te nuinga o nga polypeptides, tatou e riro rite te wahi o te kai tōtika hākinakina ka waiho "tapahia" peptidase me kore e whai i te pānga e hiahiatia ana, ranei ka waiho i te pānga ngoikore. I roto i tenei peptides IPH poto he wahi o te kai tōtika hākinakina tonu i te kopu, me paru tomo te bloodstream me te kopa, kahore whawhati e. I tēnei wā hangaia Ideal Pharma GmbH ka synthesized te raupapa o peptides poto, ka karanga IPH, mo te ho'oraa, kai, Paku me hākinakina ahumahi, e whakaongaonga te ārai, ngā pūnaha io me endocrine, whai āhuatanga antioxidant, whakahohe pākia me te mahi mo te ārai o te mate pukupuku, me te nui haere te pikinga [5, 6, 7, 8]. Me kï reira e kore e mohio tonu polypeptides te huarahi tangohia o mahi koiora, te mea mau nui māmā hoki peptides poto IPH taua rangahau, me te ake ki ira taea tatou te ahu i te huarahi katoa mahi peptide [1, 5, 6, 7, 8, 10 ]. Tenei taea ki a koe te faaineine māia te mo te miramira, me te haumaru o peptides IPH poto whakaputaina e Ideal Pharma GmbH (Germany).

Ko te kupu, ko nga peptides poto IPH, he katoa o te pānga koiora o polypeptides, haumaru, kore-immunogenic, whai tikanga e hāngai ana pūtaiao-o mahi, me te ko te otinga pai rite te wāhanga kai tōtika hākinakina [4] me te pere o te whanaketanga o te Pūtaiao hou, me te rongoā rāpoi.

Rauemi whakau te miramira me te haumaru o peptides poto

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2. Zilov IS wāhanga Pūmua i roto i ngā kai motuhake mō kaitākaro // Nutrition. - 2014. - T.83, №53. - C. 133.
3. Mezenova NY, vertuhaya vv, Volkov vv, Baydalinova LS Mezenova OJ Whakatau i o ngā tawhā hangarau o puehu o peptides kaha i unahi ika hei wāhanga o te bio-hua ki te kai tōtika hākinakina // Nga mahi o te whare wānanga. Applied Matū ko Biotechnology. - 2016. - №2 (17). - S. 104-114.
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9. Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ te peptide punaraungao-hāngai, SS-31, whakapai ake hoahoanga glomerular i roto i kiore o tau matatau // tākihi Int. 2017. S0085-2538 (16) 30652-4.