Rerekētanga Mutational me ngā momo o irakētanga

Ko te wā "irakētanga" mai i te Latino kupu "huringa", e mooni te tikanga - huringa ranei huringa. rerekētanga Mutational tohu whakarerekētanga pūmau, me te kitea o te rauemi ira whakaaturia e te i roto i te huru tuku. Ko te hononga tuatahi i roto i te hanganga mekameka me te pathogenesis o mate tuku tenei. Kua kua kaha ako tenei āhuatanga i roto i te hawhe tuarua o te rau tau 20, a inaianei kua neke ake te maha ka taea e koe te whakarongo ai kia ako i te rerekētanga mutational rite te pai kia rite ki te mōhiotanga me te māramatanga o tenei huarahi riro te kī ki te upooti'araa i te raruraru o te taata nei.

He maha ngā momo o ngā irakētanga i roto i te pūtau. Tei ratou whakarōpū i runga i nga momo o te pūtau ratou. irakētanga Generative puta i roto i te pūtau iroriki, tīari hoki pūtau germline. E riro Tetahi huringa me te maha kitea i roto i te pūtau uri, i whakatupuranga ki whakatupuranga haere te he maha o ine i te mutunga hei te take o te mate.

irakētanga Somatic He pūtau tōkai. Ratou taa ko e puta ratou ki te takitahi e kua puta mai anake. ie e kore e huringa tuku iho ki ētahi atu pūtau, engari anake ka wehea i roto i te tinana kotahi. whakakitea Somatic rerekētanga mutational te kitea, ina haamata te reira i roto i te tīmatanga o te wāhanga. Ki te puta he irakētanga i roto i te tīmatanga o te kuru kākano, i reira te mea he rārangi pūtau nui rerekē i ia atu ngā tohuira. Nä, ko te roa e kawe nga pūtau te irakētanga, kua karangatia e taua kaiao mosaic.

Taumata o ngā hanganga ira

whakakitea rerekētanga Mutational te i roto i te hanganga iranga e rerekē taumata rerekē o te whakahaere. Ka taea e irakētanga puta i te taumata ira, pūira me te genome. Runga anō i tenei huringa me te momo o te irakētanga.

pā huringa ira hanganga DNA, ai taui te reira i te taumata rāpoi. Taua huringa, i roto i ētahi wā e kore e pā te noho tuwhera tonu o te pūmua, arā, e kore e mahi te huri. Otiia i roto i te tahi atu te wā, kia kia mātauranga hapa e mutu kē te pūmua ki te mahi i tona mahi.

Irakētanga i te taumata pūira kawe kē te riri nui no te pānga ratou te hanganga o te pūira mate. Ko te hua o tenei rerekētanga ko huringa i roto i te hanganga o ngā pūira, me i reira e kua rave rahi ira whai wāhi. No te mea o tenei, kia huri i te reira i te huinga diploid noa, i roto i te tahuri taea e whai i te pānga i runga i DNA katoa.

irakētanga Genomic rite pai rite te pūira e taea meinga te hanganga o te mate pūira. Tauira o te irakētanga i tenei taumata - aneuploidy me polyploidy. Tenei hua heke ranei i roto i te maha o ngā pūira i mo te tangata ake pea ki te e whakamate.

irakētanga ira pā ana tātoru, tohu te aroaro o toru ngā pūira huirua i roto i te karyotype (nui hua). hua deflection pērā i roto i te hanganga o Edwards Syndrome me te syndrome o Raro. Monosomy tikanga te aroaro o tetahi anake o nga ngā pūira huirua rua (nui te iti iho), tata whakakore i te whanaketanga noa o te ira.

Ko te take o enei ari he maumaui i ngā wāhanga rerekē o te whanaketanga o ngā pūtau iroriki. puta tenei rite ki te hua o takaroa anaphase - ngā pūira huirua i roto i te wehenga pūtau nekehanga ki te amo, me tetahi o ratou i taea te pupuri ake. He hoki te ariā o "disjunction-kore", ka kore e taea te wehea te pūira ki ngā wāhanga o te whāū pūira ranei. Nā tēnei, i roto i te faaiteraa o disorders o rerekē pakeke. Ko te ako o tenei āhuatanga ka āwhina i ki matakawa te huarahi o, a pea ka meinga e taea ki te matapae me te whakaawe i ēnei tukanga.