Waikawa Ursodeoxycholic: tohutohu mō te whakamahi, analogs, arotake

Tata nei, mo te maimoatanga o ngā pāpaka ate te piki whakamahia waikawa ursodeoxycholic. Tohutohu mō te whakamahi o te pūhui matū tohu tona whai huatanga i roto i maha mate nui. He aha te mea tenei mea? He aha te mea waikawa ursodeoxycholic? I roto i te mea hua ko reira hakari?

whakaahuatanga

waikawa Ursodeoxycholic, te whakamahi o nei e hāngai ana i runga i tona take me ngā āhuatanga, ko te paura ma-kōwhai tioata. He he reka kawa. Tenei taonga ko roto i te rauropi tangata tikanga mahi e whakaputaina i roto i te rahinga iti. Ko tōna mahara motuhake ko e pā ana ki te 5% i te taimaha o te katoa waikawa ate. He hydrophilic reira me kua kahore cytotoxicity. he wairewa i roto i te waipiro me te waikawa ahetiki glacial, paku wairewa i roto i chloroform me tata rewakore i roto i te wai i tenei pūhui matū. e kore te waikawa Ursodeoxycholic roto i te hua. i kitea te reira i roto i te tōngāmimi au o te pea parauri.

waikawa Ursodeoxycholic (UDCA) ko he epimer o waikawa chenodeoxycholic. I te tīmatanga i whakamahia ai mo te maimoatanga o te Reflux gastritis me gallstones te wāwāhi. Neke atu i te wa, ka anga reira ki te whakamahi, me te i roto i te maha atu mate. UDKH whakaaro te haumaru tino o waikawa ate.

Pānga o te waikawa ursodeoxycholic

Ki te rā, te whakamahi UDKH ko te therapy paerewa mō te ngā mate ate cholestatic ki te wāhanga autoimmune. Ko te tikanga o te mahi o tenei kaihoko ko ki ū ai te pūtau o te tinana. Ka taea te whakauru ona rāpoi ki te kiriuhi o ngā pūtau ate - hepatocytes. No te mea o tenei e taea ki te hanga a ratou ake ātete ki ngā āhuatanga ha'iriiri ratou. Tenei māngai hepatoprotective he pānga choleretic. UDKH whakaiti cholesterol te kōtuitanga i roto i te ate, me ārai tona absorption i roto i te piro. Whakahekea tenei tarukino, me te whakaara ake lithogenicity ihirangi waikawa bile reira. whakarei ake te reira i te mahi o te lipase, pancreatic me te secretion pekitīlia. waikawa Ursodeoxycholic he pānga hypoglycemic me whakaongaonga te hanganga me te wehenga o te ate, te whakaiti i te reira cholesterol.

Tenei raau pai wāhinga wāhanga oti ranei o kohatu cholesterol. Ko reira he aha te whakamahia atu pinepine. Hono ki te cholesterol, faarahi te reira i te memehatanga o ona tioata, e mahi deleteriously i runga i gallstones. UDKH He mahi immunomodulating i te ki te whakapiki ake i te mahi lymphocyte, te whakaiti i te faaiteraa o antigens rerekē i runga i te kiriuhi o hepatocytes. Pānga ki te maha o T-lymphocytes, te whakaiti i te maha o eosinophils.

whakaiti UDKH te kukū o te cholesterol i roto i te ate e tona manene, me te whakawhitinga o te taonga i roto i te wāhanga karaihe wai. pānga te reira i te tohanga enterohepatic o Mariao ate. Ka rite ki te hua o tenei heke reabsorption i te punuatuna o pūhui hydrophobic me paitini endogenous. Tenei raau he hepatoprotective hāngai, me te pānga choleretic. waikawa Ursodeoxycholic, i nei arotake o tohunga i roto i te hepatology whakaatu tona whai huatanga, he ahei o te whakaiti ate kakakīrehe i roto i tona e hōloa fatty.

tono

whakaritea waikawa Ursodeoxycholic, whakamana nei tono i raro i te te tirotiro o te rata haere i taua tikanga pathological:

• aroaro o kohatu cholesterol paetata i roto i te gallbladder mahani noa ranei;

• ki te ngoikore hamani endoscopically hāparapara ranei;

• ma'i, mohiotia, me whakapeka kakā autoimmune ;

• aroaro o cholesterol kohatu i muri i aunoa me te extracorporeal lithotripsy;

• paitini (whakapōauau, waipiro), ate kino;

• sclerosing cholangitis;

• cirrhosis biliary tuatahi, me kahore tohu o decompensation;

• atresia, wahi biliary;

• kakakīrehe whēwhē;

• kakā hohe ma'i;

• cholestasis i roto i parenteral kai tōtika;

• dyskinesia biliary;

• biliary syndrome dyspeptic ki dyskinesia biliary me holetsistopatii;

• opistorhoze ma'i;

• atresia biliary congenital;

• biliary Reflux esophagitis me Reflux gastritis.

waikawa Ursodeoxycholic (UDKH) e whakamahia ana mō te ārai o te kino ate piri e whakahaere o cytostatics me te whakawhānau hormonal. Kei te whakaritea te reira no te tahi atu mate meinga e stagnation o ate. UDKH whakaritea hoki therapy adjuvant i roto i te ate transplantation atu okana ranei.

contraindications

waikawa Ursodeoxycholic, e arotake te wahi tino pai, he contraindications nui. Ko ētahi o ēnei:

• mate inflammatory o te au tōngāmimi, whekau, me aerodynamics ate i roto i te wāhanga whakapeka;

• gallstones rentgenopolozhitelnye ki te ihirangi konupūmā tiketike;

• arai o te wahi biliary;

• hypersensitivity;

• cirrhosis i roto i decompensation;

• mate o Crohn;

• korerotia kōtītiti i te mahi o nga repe taiaki, ate me te tākihi.

whāititanga o te whakamahi

waikawa Ursodeoxycholic, tohutohu hoki te whakamahi i mārama tohu te ngaro o whāititanga tino i roto i tona tono, e kore e whakaritea pēpi ake ki te 3 tau i roto i te puka capsule. Hoki ratou whakamahi penei i te slurry ngā tenei taonga tarukino. Tae noa inaianei, kahore i tohunga i whakahaeretia rangahau e tika ana e hāngai ana te whakatau i te pānga o tenei taonga cholelitolitic i runga i te tau o te tamaiti rānei. I te wa ano, kihai i rangahau whakahaere i roto i te aroaro o ngā tamariki ki te atresia biliary me etahi mate ate whakaaturia raruraru pediatric motuhake.

Teuteu kei roto waikawa ursodeoxycholic, hoatu ki nga wahine hapu anake, no te mea nui atu te tūpono ki te tamaiti e parauhia te pānga e tūmanakohia ana o therapy ki tenei kaihoko. kia kore tatou e wareware e te ako pūtaiao ki tonu o te haumaru matū mō tenei kāwai o tūroro kua pau tangata. Mai kore te mohiotia ranei te ô i UDKH ki te waiu, uma, e hiahiatia ana tūpato kei roto i te whakarite o te tarukino ki wahine te u.

pānga taha

waikawa Ursodeoxycholic, tohutohu hoki te whakamahi i tohu te whāititanga kore anake i roto i tona tono, engari ano hoki ki ngā pānga taha taea, kia arahi ki ari pathological pērā i:

• kōroke, korere;

• whakapairuaki;

• nui haere transaminases;

• mamae i roto i te hautahi runga tika, me te rohe epigastric;

• tauhohenga kiri pāwera (minamina, ponana);

• kohatu calcining.

Maimoatanga o te cirrhosis biliary tuatahi ētahi wā ai tenei faaineineraa e te manawanui he decompensation tuao, ngaro i muri i withdrawal te fariiraa i tenei tarukino.

mehua whakatūpato

Hei litholysis pai kohatu cholesterol te whakamahi i UDKH Me ki te tango i ki pūkete te tikanga e whai ake nei:

• e kore te mea neke atu i te 2 cm ratou rahi;

• e kore ratou e whakarato whakamarumaru i runga i te radiograph;

• Kei te mahi te tikanga gallbladder;

• mau tonu aerodynamics patency;

• he mirumiru ki tonu ki te kohatu iti iho i te hawhe;

• e kore e te tau mahani ate noa i roto i nga kohatu.

He aha ētahi atu here i runga i whakauru ki te waikawa ursodeoxycholic? Tohutohu ki tenei taka hauora tohu e te maimoatanga wā roa-, i te mea neke atu i te 1 marama, me kia auau (1 nga 30 ra) ki te whakahaere aroturuki o transaminases ate, phosphatase, bilirubin, gamma-glutamyl transferase toto. He tino nui i roto i te tuatahi 3 marama o te therapy ki UDKH whakahaere taua tätari. whakapumautia te tōtika o te maimoatanga e X-ray katoa ono marama, me te ultrasound ate. tonu ki te maimoatanga cholelithiasis me muri oti whakakorenga o kohatu hoki te ārai o te hohokitanga o hukihuki. Ka taea e te tango te reira maha marama.

I roto i te maimoatanga UDKH wahine o te whanautanga tamariki tau tūtohu te ki te whakamahi i ngā tikanga pono o te tiaki ki te hapūtanga. pea te reira i taero kore-hormonal ranei te whakawhānau kei roto moni iti o estrogen.

puka Tuku me te inenga

waikawa Ursodeoxycholic, i nei te ako ā-homai he whakamārama taipitopito o tona circuitry fariiraa, e hangaia i roto i taua momo inenga:

• Tōpata me papa o 150 me 250 mg;

• whakatārewatanga mō ngā tamariki.

Inenga UDCA tino whakaturia takitahi. Tei te reira i runga i te pakeke o te huru tangata me tona taimaha tinana. I roto i te nuinga o te wā, kua whakaritea ai e 10-20 mg / kg ia ra. tangohia ana tēnei horopeta i tetahi wa, i roto i te ahiahi. Ko te roanga o te therapy tei runga i te taunakitanga. horomia ana tēnei raau i roto i te kōpiro iti, ka muri 3 haora tuhia te wē kei mo tona kukū rawa. medicaments fariiraa tamau kei roto waikawa ursodeoxycholic, hanga ana e ia te waikawa ate tuatahi i roto i te tinana tangata. I waiho i raro tēnei rauemi ki te whānuitanga o ngā panoni, me te hua whakamutunga, ko te putanga rite metabolites i roto i feces me te mimi.

whakaritea roanga o te therapy e te rata haere. Ka taea e te reira rerekē i runga i te momo o te mate rānei. I roto i te tahi mau take kino, te fariiraa UDKH taero pumau mo tau.

Ngā pāhekoheko ki ētahi atu taero

I roto i te fariiraa tahi me UDKH "Cyclosporine" piki ohorere te absorption o te muri. I roto i te wē tino whakanuia ana te kukū o teuteu rongoā. I roto i wā onge te fariiraa UDKH tukutahi ki te faaineineraa "Ciprofloxacin" heke kukū whakamutunga.

waikawa Ursodeoxycholic (analogues)

waikawa Ursodeoxycholic (capsules, papa) hangaia i raro i ngā ingoa rerekē. rerekē taua āpiha excipients tomo ki to ratou hanganga. Ko te kupu, Ka taea e te mākete te whakatau enei taero ki te waikawa ursodeoxycholic:

• Tōpata "Ursosan" whakaritea mō te therapy mate ate E ruia ana, cholelithiasis, ki biliary gastritis Reflux me Reflux esophagitis, cirrhosis tuatahi, taero me kino ate paitini, cholecystectomy, mate waipiro, sclerosing cholangitis, Biliary atresia, steatohepatitis nonalcoholic. Kei te whakamahia te waikawa Ursodeoxycholic ( "Ursosan") mo te ārai o pāpaka ate.

• Papa "Ukrliv" e tango i te waimaerotanga ate, kakā, cholelithiasis.

• Tōpata "Ursofalk" whakaingoatia mo ngā mate o te gallbladder me ate, haere tahi e te cholestasis, he hekenga o etahi mahi ate, taumata cholesterol faateiteihia. Ko ētahi o ēnei cirrhosis tuatahi biliary me sclerosing cholangitis, Reflux gastritis me Reflux esophagitis, kakā o etiology rerekē, kohatu cholesterol, kakakīrehe whēwhē, pāpaka maha o te ate, ate stasis. whakamahia tēnei faaineineraa te rite he prophylactic ki ate whara, ka te fariiraa i taero puai.

• Papa "Ursodeks" e tango i cirrhosis biliary kahore tohu decompensation me Reflux gastritis. E whakamahia ratou ki te tareka ia kohatu cholesterol iti i roto i te mahi noa o te tōngāmimi kawa.

• Tōpata "Ursodez" whakamahia ki te wahia iho kohatu cholesterol, te maimoatanga o te Reflux gastritis, mo te therapy symptomatic mō te cirrhosis tuatahi o te ate, me kahore he tohu o te decompensation.

• Tōpata "Ursolizin" whakaingoatia mō te tātau kohatu cholesterol, me te maimoatanga symptomatic o cirrhosis biliary, gallbladder cholesterosis me Reflux gastritis. whakamahia te raau i roto i te therapy matatini mō ngā tūroro ki kakā me cirrhosis.

• Tōpata "Choludexan" whakamahia mo te maimoatanga o te cholelithiasis ngāwari, kakā kaha, pāpaka ate waipiro, me te paitini, steatohepatitis nonalcoholic, cirrhosis biliary tuatahi, cholangitis sclerosing tuatahi, kakakīrehe whēwhē, dyskinesia biliary, Reflux gastritis me Reflux esophagitis.

• Tōpata "Urdoksa" e kua whakaritea i roto i te cirrhosis biliary tuatahi, me kahore tohu o decompensation, Reflux gastritis. Ko te raau pai memeha nga kohatu cholesterol iti, me te reo, i te tiaki i te mahi noa o te tōngāmimi kawa.

• Tōpata "Pehu C", whakaritea i cholelithiasis ngāwari, cirrhosis tuatahi, whakapeka, me te kakā, sclerosing cholangitis, atresia wahi intrahepatic, Reflux gastritis me Reflux esophagitis, cholestasis, i roto i parenteral kai tōtika, dyskinesia biliary, mate ate, me kakakīrehe whēwhē, gepatoze ngako, syndromes dyspeptic. Kei te whakamahia te faaineineraa no te ārai o te kino ate i roto i te whakamahi o te whakawhānau hormonal me cytostatics, kohatu hanganga i roto i te mōmonatanga.

waikawa Ursodeoxycholic, analogs o tenei rauemi e tangohia anake whakaritea e te tākuta.