Erythropoietin recombinant. erythropoietin tangata recombinant

Erythropoietin (EPO) - glycoprotein taiaki e whakahaere te tere o te erythropoiesis i roto i te tangata. synthesized te pūhui hakari te matua i roto i nga whatukuhu, whakaputaina he nui iti (e pā ana ki 10 ōrau) te roto i te ate. Ko te hōmone erythropoietin whakahohetia te wehenga me te pārōnaki o kuí erythroid. Taumata o te taiaki endogenous i roto i te wē toto o te mau taata hauora rerekē i roto i te whānuitanga whanui, me te he inversely hautanga ki te kukū pūtoto, me te tohu o te oxygenation o te kopa. Mahi i runga i te wehe, me te hanga o tenei taiaki i roto i te tikanga ki te rongoā, ko te tino whai hua.

Hanganga me te uara taiaki

Kei te rāpoi ngota o waikawa amino taiki. I kua hē o erythropoietin endogenous kua he hekenga koi i roto i te taumata o te pūtoto, me ngā pūtau toto whero, kei te whakawhanake i te reira i te anemia eritropoetindefitsitnaya pera-ka karanga. noho taea e tika ki te kore o te rongoā e tika ana Kia tata, he taua te ako tarukino o anemia. I teie mahana, me te tarepa i runga te taiki i roto i te tinana tangata, whakahau tākuta erythropoietin recombinant. Te faaineineraa whiwhi i ngā pūtau kararehe i roto i nei te waehere ira whakaurua hoki EPO tangata. Recombinant erythropoietin tangata i roto i te waikawa amino me te warowaihā hanganga he ōrite ki te taiaki tūturu, faarahi te maha o ngā pūtau toto whero, reticulocytes, whakahohetia te biosynthesis o pūtoto i roto i te pūtau. Ko kahore rerekē i te taiaki endogenous te mahi koiora o te rauemi hua. e kore e erythropoietin recombinant whakaatu pānga cytotoxic me e kore e pā te leucopoiesis. Scientists whakaaro e pähekoheko EPO ki receptors eritropoetinchuvstvitelnymi motuhake, e kua kei i runga i te mata pūtau.

He tukanga hoki purenga erythropoietin tangata recombinant

Recombinant EPO tangata - ko tetahi o te pūmua nui tino whakaputaina e maha kamupene koiora me te rongoā huri noa te ao mō te therapy tarukino. synthesized te pūhui hakari te pūtau kura kākano hamster Hainamana (cho) e tikanga DNA recombinant. Kotahi polypeptide mekameka recombinant EPO kei 165 waikawa amino, te taimaha rāpoi tatau o 24,000 Yeah, me te taimaha rāpoi kitea o te pūmua glycosylated - 30 400 Da. kawea Manga erythropoietin i poke i roto i te katote-utu, me te ara pakuwha tūrara. Tangata recombinant EPO kua he te viivii o 98%.

erythropoietin recombinant me analogs ona

Hei whakaongaonga erythropoiesis tukanga tākuta whakamahi rerekē taero:

• "Aranesp";
• "Aeprin";
• "Epobiokrin";
• "Bioein";
• "Vepoks";
• "Binokrit";
• "Epokrin";
• "Gemax";
• "Epogen";
• "Eprex";
• "Epovitan";
• "Epomaks";
• "Giperkrit";
• "Eralfon";
• "Eritereia";
• "Recormon";
• "Epostim";
• "Epozino";
• "Epoetin Beta".

I mua i te whakakapi koe he analogues erythropoietin recombinant, kia kōrero i te rata.

Tuhinga

maha i ngā Medical ki te mahi ki eritropoetindefitsitnymi anemia (EDA). Tenei rōpū ngā te pathologies e whai ake nei:

• anemia o neoplasms mārere;
• anemia wawe o ngā kōhungahunga prematurity (i mua i 34 wiki gestation) ki te taimaha tinana o 750 ki te 1500 g;
• anemia nephrogenic;
• Anemia i roto i mate mau (kakā C, kaikōiwi, HIV mate, alimentary mate awa).

He āhuatanga motuhake o te anemia runga ake-hē ko te meka e kore e tukinotia ratou taka rino. Tae noa tata, te therapy whai hua anake ko te huhu. Nā ki te meka e te maha nui o ngā pānga taha me te mōrearea nui o te tuku o tukumate toto-whanau o mate kino hopuhopu (HIV, huaketo kakā, me ētahi atu) i tenei momo o te therapy kua, tenei tikanga i roto i te rongoā hou te tata kore whakamahia. tauturu recombinant erythropoietin tangata ki te whakapai ake i te kounga o te ora mō ngā tūroro ki te tātaritanga o "eritropoetindefitsitnaya anemia." Biosynthesis me introduction o recombinant EPO tangata whakatuwheratia he wā hou i roto i te maimoatanga o te anemia eritropoetinzavisimyh.

contraindications

e kore e Doctors tūtohu te whakamahi o te erythropoietin recombinant (faaara ā-e pā ana ki reira) i roto i te aroaro o nga pathologies e whai ake nei:

• thromboembolism;
• hypersensitivity ki te tarukino;
• eita o therapy anticoagulant whai hua;
• whakawhiti patunga kaka infarction myocardial ranei;
• angina iu;
• takawhita whakakeke;
• wā o te haputanga me te ū;
• takawhita whakangutungutu.

talena dosing

Kua whakapumautia ana te inenga me te roanga o te kaupapa maimoatanga i roto i te pūtake tino takitahi, i runga i te pakeke o anemia, te huru whānui o te manawanui, me te āhua o te māuiuitanga rānei. tikanga te tarukino te mo te whakamahi parenteral. Ka taea e pota tuatahi rerekē i roto i te whānui i te 50 ki te 150 Iu / kg. kia whakaritea te horopeta i runga i tau o te manawanui rānei. Kei te nuinga o te wā erythropoietin recombinant whakahaere 3 ngā wā i te wiki. Ki te kua tuwhena rawa kua piki haere ngā pānga taha. Ko te hua riro atu iti iho ranei kitea i muri i 2-3 wiki o tono.

pānga taha

whakaritea e koe erythropoietin tangata recombinant? Tohutohu mō te Whakamahi e kore e tutakina i te whanaketanga o ngā pānga taha. Ko ratou:

• myalgia;
• whanoke;
• tūāhuruiti;
• te momoe;
• ruaki;
• ānini;
• korere;
• arthralgia;
• takawhita;
• mamae pouaka;
• thrombocytosis;
• tachycardia;
• raruraru hypertensive;
• haehae;
• steatosis;
• te whakatairanga i te taumata o AST, ALT i te toto;
• ngeniwhero aplasia iroriki pūtau;
• katoatia;
• angioedema;
• ponana kiri me te apohia e;
• asthenia;
• pununga honé, whero, me te tahu i te pae o te whakahaere;
• hyperkalemia;
• whakaiti o te kukū pūmua i wē ferritin;
• hyperphosphatemia.

faaitoitoraa Erythropoiesis i roto i hākinakina

Aita i maoro a'e, pinepine whakamahia tarukino "Epovitan" (recombinant erythropoietin tangata). Kei te maha whakamahia te taputapu reira i roto i te hākinakina (kaiaka, bodybuilding, kauhoe, kilometera). Ka mea faaineineraa whakahohetia te biosynthesis o ngā pūtau toto whero, i roto i te tahuri arata'i ki te hua i roto i te ihirangi o te hāora ia rōrahi wae o te toto, me te, no reira, ki te hua i roto i te kaha toto hāora me e ₂ tuku ki whēkau me te kopa. faarahi tenei tikanga o te mahi te manawanui takohe o te kaipara. kitea te pānga rite te ka te whakangungu i te maona i roto i te Waenga, i reira te kore o te e ₂ i roto i te rangi ai te whanaketanga o te hypoxia, i roto i te tahuri whakahohetia te biosynthesis o erythropoietin endogenous. E whakamahia EPO taka i roto i ngā ki taiāki, taiki (GH, somatotropin) me te stanazolol.

Nui, te whakamahi whakakeke o "erythropoietin" tarukino i roto i hākinakina taea meinga clots toto e te tikanga arata'i ki te mate. Rapu Ko te tino uaua recombinant EPO, no te mea he ōrite ki tona tairitenga whaiaroaro te hanganga pūhui waihanga, na tenei biosoedinenie tonu hetia whakamahia i roto i hākinakina tiketike-mahi rite doping.