Inhibitors iraoho papu: tikanga o te mahi me te tono i roto i te rongoā

Na roto i te inhibitors papu iraoho ko te rōpū o āpiha pharmacological e whakaiti i te auau o te secretion o te waikawa pūhaumāota i roto i te kopu. He he pānga tika i runga i nga canaliculi secretory, ratou tōtika arahi ki te tuwhenua hiahiatia haumanu pānga, gastritis erosive, Gerd. Ko te rōpū ngā he plurality o taero o hanganga matū rite, engari he rerekē tawhā pharmacodynamic, i.e. ngā mahi te taua raau taero i runga i te pūtau secretory, engari rave i te reira i roto i nohanga rerekē, me te ki tere rerekē.

inhibitors iraoho papu: āhuatanga rāpoi teuteu mana

Iraoho papu ko te hanganga pūmua kătahi whakahaere matatini o ngā katote hauwai i roto i te lumen pekitīlia. Kei a ia ko e rua ngā huānga matū Nä, te kore i huaina subunits. Ko te tuatahi Ko anake o te pūmua, me te te hanga i waikawa amino. I roto i te membrane stuffer pūtau töna whanonga i roto i te ara motuhake, whiti reira 10 ngā wā, e arata'i ki te hanganga o koropiko awa 5-secretory. E haere ana i te kōhao o katote hinga i roto i nga lumen pekitīlia me te whakarato i te acidification o te reo, me te hinga taupū hauwai. I roto i tenei take ko te reira i roto i tetahi o nga koropiko ko te pokapū hohe o te pūmua - he raupapa o 800 waikawa amino, e catalyzes te rärangi o ATP, te tïpako pūtau pūngao matua.

Ētahi atu subunit Ko te matatini pūmua titoa e te o te raupapa polypeptide, aua tetahi hanganga whakahau me mekameka glycoprotein. Ko te wahi rahi o te rāpoi ngota ko waho te cytoplasm, a ka he pea te wahi o te glycoprotein matatini receptor ekstratsitoplazmaticheskim e mauria ake te tohu o te faaitoitoraa o te paru H + \ K + -ATPase. I roto i tenei take whiti te wahi pūmua o te rāpoi ngota te membrane kotahi, e parau tona uara rite te huānga tūhono i waenganui i te waho, me te subunit receptor tuatahi kawenga mō te whakahaere i te tauhohenga catalytic o te kōtuitanga o ngā iraoho.

Nä, ko te hanganga o te iraoho papu tubules secretory pūtau kōpako taea faaoti pehea ohie tikanga e taea te pehi te secretion o H + ki te kōhao tinana. Ko te whakatinanatanga tino tika - he inhibition o te whākōkī haepapa mo te kōtuitui e hanga inhibitors iraoho papu.

Whakamahi o inhibitors i roto i te mahi haumanu

I roto i te rongoā, kei te whakamahia whānuitia inhibitors iraoho papu, rawa i roto i gastroenterology, e pā ana nei ki to ratou kaha ki te whakaiti i te kawatanga o pekitīlia secretion, a ko te kupu whakaiti i te kaha o te pānga ino i runga i te taiepa puku, i te mea nui rawa ina te ahi reira. I roto i tenei take ko motuhake o te etiology o te tukanga inflammatory te pānga haumanu, rite ki te nekehia atu i te reira e te mana pukuriri o te taiao i runga i te tapatahi o te tinana. Ano te tūāwhiorangi o pathologies i nei maimoatanga mō te whakamahi whai hua o inhibitors papu iraoho kua whakawhānuitia e te whewhe pekitīlia me whewhe duodenal, erosive me ngā puka Gerd kore-erosive.

I roto i te rongoā tino noa ngā inhibitors iraoho papu ki te ingoa kano e whai ake nei omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, me ētahi atu. I roto ia ratou he tu ingoa hokohoko i roto i, pērā i "Omez". E wātea ana i roto i te puka capsule rongoā. E tangohia e ratou waha i roto i te inenga whakaritea o te mātanga, e rerekē i runga i te momo ngā o te mate. I tuku whaiaro whakahaere-, rite reira ko he rōpū o tūroro e amuamu o exacerbation tau o keha pekitīlia duodenal ranei ma'i. I roto i te tahi atu te wā, whakaritea te fariiraa e ki te tākuta i te wa o te whakauru.