Tauwehe tupu taiāki-rite: te täkupu me te ine

tauwehe tupu taiāki-rite i huaina taiki rite i roto i te hanganga matū ki taiāki. regulates te reira i tukanga pārōnaki pūtau, ratou whanaketanga me te tupu. Kei te whai wāhi hoki te reira i roto i te pākia e te kūhuka.

History o whakahura

Hoki i te mutunga o nga 50s o te rau tau rua tekau, kua fokotu'u kaipūtaiao e waenganui i taiki (takiwā), Kei te hoki i huaina nei taiki me ngā pūtau o te tinana, i reira he etahi takawaenga. E hua ana tēnei mutunga i te meka e i taiki te pānga anake i runga i te rauropi ora, engari ka te whakahaerea ai ki te pūtau uaua, ara, ki te i ratou i roto i te reo matūkai, kitea kahore pānga i.

I roto i nga tau 1970, i kitea ai somatomedins, i whakahuatia nei i te kaitakawaenga. i huaina ratou āhuatanga tipu taiāki-rite. I te tīmatanga taratahi toru ngā rōpū o matū: He somatomedin (Pua-3) ko B (Pua-2), C (Pua-1). Otiia i takoto ai i roto i nga tau 1980 e take-2 tupu taiāki-rite, me te 3 - Ko te anake he artifact whakamātautau tenei, engari i roto i te parau mau e kore e tīari reira. whakapumautia anake te aroaro o te Pua-1.

hanganga

tauwehe tupu taiāki-rite 1 (Pua-1) Kei o waikawa 70 amino e hanga hononga intramolecular ki mekameka-piriti. Ko te peptide e herea ki te pūmua wē, te take tupu taketake pera-ka karanga. tukua ratou noho hohe somatomedins nui roa. E te reira e rave rahi haora, i roto i te puka noa mea e kore he wā neke atu i te 30 meneti.

He rite ki te proinsulin, hoki i riro ia tona ingoa te taiki. A i roto i te kōtuitui o te tūranga nui somatomedin takaro e te taiāki huka tika. I muri i te katoa, whai wāhi ai ki te whiwhi i te waikawa amino hiahiatia katoa i te ate ki te tīmata i te huarahi o te hanganga o te FMI.

taiaki kōtuitanga

Ka mea tauwehe tupu whakaaro takawaenga endocrine whakarato mahi o te taiki tupu. Kei te synthesized reira e hepatocytes o te ate i roto i te whakautu ki te receptor whakaongaonga. I roto i te tata te kopa katoa whakaratohia te mahi o te taiki e Pua-1. riro ia i te ate ki te bloodstream, me i reira, i roto i te arairaa o te pūmua kawe i roto i te kopa, i nga okana. Ka mea taiki whakaongaonga te tupu o wheua, kiko tūhonohono me uaua. Ano, synthesized takitahi take tupu taiāki-rite i roto i te kopa maha. Ki te tika, ka taea e ia pūtau takitahi whakarato ratou ki tenei taonga.

Secretion o Pua-1 i te piki ate raro i te mahi o estrogens, androgens, taiāki. Ko glucocorticoids heke te reira. Kei te whakaaro te reira ki te kia kotahi o nga take he aha pā enei matū te tupu me te whanaketanga o te rauropi, me tona tere o te matuatanga fakasekisualé.

āhuatanga

Pua i roto i ngā pūtau uaua puai tupu mahi whakaongaonga me te taiāki. catalyzes te reira i te kōtuitui o te pūmua , me pōturi te tukanga o te whakangaromanga. Reira te hünuku hoki te pākia, whakatairanga i te whakatere tahunga ngako.

e pā ana taiāki huka-rite tupu tauwehe-1 te ki te repe me te hypothalamus. kitea e ia te reira i roto i te toto tei runga i te kōwhiringa o te tahi atu hormones. Hei tauira, i te kukū iti whakanuia ana te secretion o taiki. faarahi hoki hanga o te tupu taiaki taiaki-tuku. Otiia i ngā taumata teitei o te Pua-1 secretion o mea heke taiki te.

I waenganui somatostatin me tauwehe tupu taiāki-rite ko whakapumautia he hononga hāngai te. Ki te hua o tetahi piki ratou o, me te kukū o te tuarua.

kia mōhio hoki tatou e te whakamahi i te reira hei kaitäkaro anabolic kore utu reira. Kua toutou whakaputaina te reira i te hua o rangahau e kōrero ki nga hua kino o te tamataraa tango taero e roto i tauwehe tupu taiāki-rite (Pua). Ka taea e ratou tikanga arahi ki te mate huka, waimaero ataata, disorders o te uaua ngakau, neuropathy, taupatupatu hormonal. I tua atu, tenei taonga ko tetahi o te tupu o te pukupuku matepukupuku kaiwhakakökï nui.

āhuatanga Pua

Ua itehia e, e take tupu taiāki-rite 1 te tuku iho i roto i te tau tawhito, me te i roto i te tamarikitanga, ka ko reira te teitei i roto i taiohi. Engari kia rite ki te mea kua kitea e kairangahau e he ofi ki te rohe o runga o noa mo ratou rōpū pakeke te iwi pakeke nei te taumata o tenei taiaki ora roa. I tua atu, he iti iho e pängia ana ki te mate ngakau me oko toto ratou. Wehe, Ko reira ia tapao e te whakanui ake i te nui i roto i te hapū.

Toto kukū i roto i te ra, ko te pā ana ki te taua. Na reira, kua whakamahia te reira ki te aromatawai i te raruraru i roto i te whanaketanga o te taiki. I muri i te katoa, te kukū o te taiki i roto i te toto rerekē puta noa i te ra, i te taumata mōrahi tohua i roto i te po. Na reira, ki te tika whakaturia he raruraru te nui.

Whakaiti i te kukū o te ira tangata

kitea Pua-1 i anake i roto i te 1978. Mai reira kua pau tatou i te rota rawa o te rangahau, ka rite ki te hua o nei i whakaturia he maha o ture. Ko te kupu, ko te tarepa o tona tamarikitanga ko te take mo te roa o te tupu me te whanaketanga ā-tinana o te tamaiti. Otiia hoki mōrearea ki te iti take tupu taiāki-rite i roto i ngā pakeke. I muri i te katoa, kua tuhia te reira te underdevelopment o nga uaua, heke wheua kiato, huringa i roto i te hanganga o te ngako.

Meinga e te kore o Pua pea he maha o mate. I roto ia ratou, raruraru tākihi, ate. E mea pinepine te take o te nui iti o Pua ko te mate pērā i hypopituitarism. Ko te huru i roto i nei te kōhao e taea mutu hanga mārika i iti o ranei tenei hormones rapae o. Ko te whakaiti hoki te hanga o te somatomedin ki te tarepa o te mana, ranei, atu noa, te hemokai.

Ko te hua i roto i te Pua

Ahakoa te mau hopearaa nui, e ai te kore o te Pua-1, e kore te mea e tika ana ki te amo i taua te hua i roto i te maha o ona kore kino.

Na, ki te mea te take tupu taiāki-rite 1 ake, ka arahi ai ki te acromegaly i roto i ngā pakeke, me te gigantism i roto i ngā tamariki. whakakitea mate kōhungahunga te whai ake nei. timata ratou te tupu wheua kaha. Ko tenei rite ki te hua o take tupu nui e kore anake, engari nui haere ano mutunga ki te rahi ohoreretia nui.

Acromegaly, e puta i roto i ngā pakeke arata'i ki roha o te waewae wheua, ringa, me te mata. mamae ano me whekau. kia arahi tenei ki te mate e tika ana ki te cardiomyopathy - he mate i roto i nei pānga uaua cardiac, takahia tona mahi.

Nuinga o ngā wā i te take e faarahi take tupu taiāki-rite, he puku rapae o. Mai i reira ka taea e te tiki e koe whakakahoretia o ki te awhina o rongoā, hahau, a taea te nekehia atu te reira hāparapara. tauturu te tātari whakatau i pēhea te angitu therapy, tirohia ranei kawea te mahi i roto i tōtika ranei. Hei tauira, ki te te puku kei te kore e tino i nekehia atu, nui haere te kukū o Pua te.

rangahau te whakahaere

Hei tātari huringa i roto i te kukū o te tauwehe tupu taiāki huka-rite i roto i te pokapū taiwhanga hou whakamahi tikanga IHLA. Na ka karanga tātaritanga immunohemilyuminestsentny. Kei te hāngai te reira i runga i te whakautu ārai o antigens. I roto i te taahiraa wehe hiahiatia taonga piri taua ramaroa - phosphors, e he kitea i raro i te marama hihi katinga. whanganga ratou taumata o luminescence te whakamahi i ngā taputapu motuhake - he luminometer. E ai ki reira, te kukū o ngā matū tīpakohia i roto i te serum.

takanga Survey

Hei whakatau Pua-1, tauwehe tupu taiāki-rite, he mea e tika ana ki te koha toto i roto i te nohopuku obligatory ata. Whakaaetia ki te inu anake te wai mania. Ko te wā i waenganui i te kai whakamutunga me te taiepa o te rauemi mō te rangahau ki te kia neke atu i te waru haora. He mea nui kia 30 meneti i mua i te tuku o te tātaritanga i te manawanui i okiokinga. Hoki te rangahau tango toto venous.

Ano, tūtohu tohunga ki te whakarere i te tātaritanga i roto i te mate romahā whakapeka (take viral kitakita ranei) i roto i te tikanga ki te whakakore hua teka.

wawaenga

A, no te whakakī i ngā puka i roto i te taiwhanga ko reira nui ki te tautuhi i te tau. I muri i te katoa, tei reira ki runga ki a ia ka aha kia he take o te taiāki huka-rite tupu. Ko te täkupu e te whakapumautia mo ia kāwai takitahi. Ko reira tika hoki ki te arotahi kore i runga i tauwaenga engari i runga i te raraunga o te taiwhanga i roto i nei i tangohia e koe whakamātautau. Hei tauira, i roto i taiohi pakeke 14-16 tau kia taumata taiaki i 220 ki te 996 ng / ml. A i roto i ngā pakeke, i hira ake i 35 tau, e kore e nui te reira i te uara o te 284 ng / ml. Ko te tuakana te manawanui, kia waiho te raro te taumata mōrahi o te Pua. I muri i 66 tau, kua whakaturia te auau i roto i te whānui 75-212 ng / ml i muri i 80 - 66-166 ng / ml.

Ka whakawhirinaki ano tamariki Pua taumata i runga i tau. I roto i nga tamariki whanau hou, e kore nei te mea ara 7 ra, kia waiho ai i te 10 ki te 26 ng / ml. Otiia i muri i te 16 ra, me te ki runga ki te 1 tau, whakaturia te auau i i 54-327 ng / ml.

tātaritanga o mate

Ka whakaritea te taiāki huka rite tauwehe tupu, he reira taea ki te tātari i te maha o mate. Te whakanui ake i tona taumata o te taunakitanga e kore anake o gigantism i roto i ngā tamariki, me te acromegaly i roto i ngā pakeke. Ka taea e waiho hei tohu o te pukupuku pūkahukahu, me te puku, ma'i täkihi tenei. Otiia hoki kia tuhia te reira e ko te reira taea ki te whakapiki ake i, tango dexamethasone, adrenostimulyatorov Arepa, beta-blockers.

Heke ngā taumata Pua i roto i ngā tamariki kia tohu dwarfism. I roto i ngā pakeke, kei te maha heke te taumata ka hypothyroidism, cirrhosis, anorexia nervosa ranei nohopuku noa. Tētahi atu tetahi o nga take ka taea o ma'i karanga fakamasiva moe me te maha fariiraa o taero ki pota tiketike o estrogens.